HECTD3 and UBE2C

Number of citations of the paper that reports this interaction (PubMedID 33607208)
0

Data Source:
BioGRID (pull down)

		HECTD3	UBE2C
Description		HECT domain E3 ubiquitin protein ligase 3	ubiquitin conjugating enzyme E2 C
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Perinuclear Region Of Cytoplasm	Ubiquitin Ligase Complex Nucleus Nucleoplasm Anaphase-promoting Complex Cytosol Plasma Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Syntaxin Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin-like Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Exit From Mitosis Free Ubiquitin Chain Polymerization Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Exit From Mitosis Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Height ( 31562340)
Interacting Genes		17 interacting genes: BRCA1 CASP8 CASP9 CHUK HSP90AA1 PARP1 PPL RAF1 TP53 TRIOBP UBE2A UBE2C UBE2D2 UBE2D3 UBE2Q2 UBE2S ZDHHC17	36 interacting genes: ANAPC11 ANAPC2 AURKA CDC20 CKAP2 CXCR1 DTX1 ENO2 HECTD3 ITCH KLHL2 MAPK7 PCGF3 POLM PRKN PSMD4 RAG1 RBX1 RELA RNF167 RNF31 RNF6 RNF7 RYR2 STUB1 TNNC1 TRIM13 TRIM2 TRIM21 TRIM28 TRIM29 UBA1 UBA6 UBASH3B UBC UBE3D
Entrez ID		79654	11065
HPRD ID		13383	05717
Ensembl ID		ENSG00000126107	ENSG00000175063
Uniprot IDs		A1A4G1 B3KU34 Q5T447	A0A087WVK1 A0A0A0MSE8 O00762 Q5TZN3
PDB IDs			1I7K 4YII 5A31 5KHR 5L9U 8TAR 8TAU
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Metabolic Process Protein Polyubiquitination Ubiquitin Protein Ligase Binding Protein Modification Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Transferase Activity Macromolecule Metabolic Process Post-translational Protein Modification Ubiquitin-like Protein Transferase Activity Protein Ubiquitination Positive Regulation Of Execution Phase Of Apoptosis Protein K6-linked Ubiquitination ATP Binding Protein Modification By Small Protein Conjugation Protein-containing Complex Regulation Of Programmed Necrotic Cell Death Proteolysis Glial Cell Apoptotic Process Apoptotic Process Apoptotic Signaling Pathway Nucleotide Binding Response To Indole-3-methanol Response To Anesthetic Positive Regulation Of Ubiquitin Protein Ligase Activity Response To UV Programmed Cell Death Cell Death Mitochondrial DNA Repair Regulation Of Telomere Maintenance Via Telomere Lengthening Free Ubiquitin Chain Polymerization Cellular Response To Radiation Cytosol Response To Stress Proteolysis Involved In Protein Catabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Neuron Apoptotic Process Response To Cobalt Ion Protein Autoubiquitination Scaffold Protein Binding DNA Metabolic Process Response To Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Canonical NF-kappaB Signal Transduction Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Ubiquitin-protein Transferase Activity DNA Damage Response	Protein Modification By Small Protein Conjugation Protein Ubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin Protein Ligase Activity Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein Modification Process Catabolic Process Protein Polyubiquitination Protein Metabolic Process Ubiquitin Protein Ligase Binding Protein Autoubiquitination Transferase Activity Protein Monoubiquitination Protein K48-linked Ubiquitination Macromolecule Metabolic Process Ubiquitin-ubiquitin Ligase Activity Cullin Family Protein Binding Protein K6-linked Ubiquitination Protein K63-linked Ubiquitination Regulation Of Post-translational Protein Modification Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Positive Regulation Of Autophagy Positive Regulation Of Catabolic Process Protein K29-linked Ubiquitination Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Zinc Ion Binding Cullin-RING Ubiquitin Ligase Complex Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Protein K27-linked Ubiquitination Suppression Of Viral Release By Host SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Branched Polyubiquitination Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Regulation Of Protein Catabolic Process Anaphase-promoting Complex Ubiquitin Activating Enzyme Activity Ubiquitin-like Protein Ligase Activity Anaphase-promoting Complex-dependent Catabolic Process
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