HMBOX1 and LMO1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HMBOX1	LMO1
Description		homeobox containing 1	LIM domain only 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Cajal Body Nuclear Body PML Body	Nucleus Nucleoplasm
	Molecular Function	DNA Binding Double-stranded Telomeric DNA Binding Protein Binding Telomeric DNA Binding Identical Protein Binding Sequence-specific DNA Binding Protein-containing Complex Binding Sequence-specific Double-stranded DNA Binding	Transcription Coactivator Activity Protein Binding Metal Ion Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Via Telomerase Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Telomere-telomerase Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of T Cell Homeostatic Proliferation
Pathways			RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Alcohol consumption ( 23743675) Body mass index ( 31888951 26426971 28892062) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Diastolic blood pressure ( 27618447) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 34059833) Height ( 31562340) Malaria ( 31844061) Neuroblastoma ( 22941191 21124317) Offspring birth weight ( 31043758) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Response to selenium supplementation (change in plasma selenium concentration) ( 33382417) Restless legs syndrome ( 33239738) Sporadic neuroblastoma ( 28545128) Systolic blood pressure ( 27618447)
Interacting Genes		98 interacting genes: ABITRAM AEBP2 ANKRD36 APP ATP5PO BAZ2B BEND7 BRD1 BYSL C8orf33 CARD9 CBX8 CCDC187 CCNG1 CDC7 CDCA8 CDK18 DAB1 DNTTIP1 DYNLL1 ENKD1 ENTPD2 FAM13C FAM161A FAM217B FAM74A4 FAM90A1 FARS2 FGF11 FNDC11 FRMD6 FXR2 GAS2L2 GNL3L GSC2 INO80B IPO13 KAT5 KIF9 LMO1 LMO3 LNX1 MAGEH1 MCRS1 MEOX1 MEOX2 MFAP1 MORF4L1 MORF4L2 MRPL11 MRPL28 PAX5 PAX6 PIAS2 PICK1 PIP4K2B PKD1P1 POLDIP3 POLL PRKAA1 PRKAA2 PRPF18 RBMY2FP RCOR3 REEP6 RPL9 RPS25 SAP30L SCNM1 SDCBP SFR1 SH2D4A SNRPB2 SNW1 SYT6 TBP TCEA2 TCEANC TSGA10IP TUFM U2AF2 UBA6 UBE2I UBE2Z VAX1 VPS72 WT1 ZBTB24 ZBTB26 ZFYVE26 ZMAT2 ZMYM5 ZNF250 ZNF337 ZNF417 ZNF581 ZNF587 ZNF688	122 interacting genes: ABI1 ABI2 ADAMTSL4 AKAP9 AKNA ASB15 BANP BCAS2 BCL11A BIVM BLZF1 BNC2 BYSL CARD9 CBY2 CCDC33 CCDC88B CDCA7L CDX4 CEP170P1 CEP44 CEP57L1 CHCHD3 DDIT4L DRC4 ERBIN EVI5 FBXO16 GABPB1 GATA3 GOLGA2 GPATCH2L GPRASP3 HDX HGS HMBOX1 HMG20A HNRNPH1 HNRNPM HOMEZ HSPB2 HSPB2-C11orf52 IKZF1 IKZF3 ISY1 KANK2 KCTD1 KIAA1328 KRABD4 KRT16 KRT40 KRT75 LDB1 LDB2 LPXN LYL1 LZTS1 LZTS2 MAD1L1 MBD3L1 MEOX2 MISP MSS51 NAGK NDUFA7 NHLH1 NTAQ1 NUTM1 PHC2 PICK1 POLR3GL PPP1R13B PRDM6 PSMB1 PTPN3 PXN RBBP8 RCN1 REL SAXO1 SNTA1 SOX5 SPG21 SYTL4 TADA2A TAL1 TAL2 TASOR2 TCF4 TCP10L TFIP11 TLE5 TRIM27 TRIM35 TRIM54 TSC22D4 UFSP2 UHMK1 UNKL UTP14A VBP1 WASHC1 ZBTB43 ZBTB8B ZCCHC12 ZFP90 ZNF143 ZNF177 ZNF19 ZNF219 ZNF24 ZNF354C ZNF417 ZNF460 ZNF511 ZNF526 ZNF559-ZNF177 ZNF620 ZNF641 ZNF688 ZNF76 ZNF84
Entrez ID		79618	4004
HPRD ID		07964	01738
Ensembl ID		ENSG00000147421	ENSG00000166407
Uniprot IDs		Q6NT76	E9PK83 P25800
PDB IDs		2CUF 4J19
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nuclear Speck Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Lipid Droplet Disassembly Protein Binding Positive Regulation Of DNA Repair NuA4 Histone Acetyltransferase Complex Regulation Of Macromolecule Biosynthetic Process Phosphatidylethanolamine Biosynthetic Process DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleic Acid Metabolic Process Regulation Of Macromolecule Metabolic Process DNA Recombination Chromatin Organization Spliceosomal Complex Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Response To Glucose Starvation Protein Localization To Lipid Droplet Positive Regulation Of DNA Metabolic Process Phosphatidylcholine Biosynthetic Process Positive Regulation Of Glycolytic Process Somite Specification Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of DNA Repair Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process AMP-activated Protein Kinase Activity Phosphatidylethanolamine Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA Metabolic Process Regulation Of Tubulin Deacetylation Astrocyte Differentiation	Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus DNA Binding Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Zinc Ion Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Regulation Of Actin Nucleation Negative Regulation Of Metabolic Process Identical Protein Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Negative Regulation Of Macromolecule Metabolic Process Catalytic Step 2 Spliceosome Response To Muramyl Dipeptide Cytoskeleton Negative Regulation Of Macromolecule Biosynthetic Process Metal Ion Binding Regulation Of Arp2/3 Complex-mediated Actin Nucleation
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