RIC3 and TMEFF2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RIC3	TMEFF2
Description		RIC3 acetylcholine receptor chaperone	transmembrane protein with EGF like and two follistatin like domains 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Neuron Projection Neuronal Cell Body Intracellular Membrane-bounded Organelle Synapse	Extracellular Region Membrane
	Molecular Function	Protein Binding Acetylcholine Receptor Binding Protein Folding Chaperone	Protein Binding
	Biological Process	Protein Folding Positive Regulation Of Cytosolic Calcium Ion Concentration Synaptic Transmission, Cholinergic Protein Localization To Cell Surface Protein-containing Complex Assembly Positive Regulation Of Protein Localization To Cell Surface	Response To Stress Cell Differentiation Negative Regulation Of Cell Migration Wound Healing, Spreading Of Cells Negative Regulation Of Integrin Biosynthetic Process Negative Regulation Of Stress Fiber Assembly
Pathways
Drugs		Theophylline
Diseases
GWAS		Blood protein levels ( 30072576) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Malaria ( 31844061)	Adult body size ( 32376654) Adventurousness ( 30643258) Adverse response to drug ( 30420678) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Diabetes (incident) ( 17903298) Schizophrenia ( 33169155) Sudden cardiac arrest ( 21658281)
Interacting Genes		16 interacting genes: BCL2L1 CACNA1C CLN6 FA2H FATE1 GOSR2 NINJ2 PRB1 STX12 STX7 TMBIM1 TMEFF2 TMEM11 TMEM86A TRAF3IP3 YIF1A	12 interacting genes: DNAH7 DRD2 HSF2BP HTR4 NBPF19 NOTCH2NLA RIC3 STAT4 TMEM237 TRHR UBIAD1 ZDHHC15
Entrez ID		79608	23671
HPRD ID		17974	05760
Ensembl ID		ENSG00000166405	ENSG00000144339
Uniprot IDs		A0A0S2Z607 A0A0S2Z6D3 B7Z3Z0 Q7Z5B4	Q9UIK5
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane SNARE Complex SNAP Receptor Activity Membrane Organization Endoplasmic Reticulum SNARE Binding Vesicle Fusion Organelle Membrane Fusion Regulation Of Protein Localization To Plasma Membrane Organelle Fusion Golgi Membrane Endoplasmic Reticulum Membrane Regulation Of Protein Localization To Cell Periphery Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Protein Localization To Plasma Membrane Membrane Fusion Regulation Of Protein Localization To Membrane Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apoptotic Process In Bone Marrow Cell Mitochondrial Outer Membrane Negative Regulation Of Integrin Biosynthetic Process 4-hydroxysphinganine Ceramide Fatty Acyl 2-hydroxylase Activity Free Fatty Acid 2-hydroxylase Activity Fatty Acid 2-hydroxylase Activity Glycosphingolipid Metabolic Process Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Endomembrane System Vesicle Docking Negative Regulation Of Fas Signaling Pathway Sebaceous Gland Cell Differentiation Glucosylceramide Biosynthetic Process Regulation Of Sebum Secreting Cell Proliferation Regulation Of Acinar Cell Proliferation Alkenylglycerophosphocholine Hydrolase Activity Dendritic Cell Proliferation Dendritic Cell Apoptotic Process Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential Calcium Channel Activity Voltage-gated Calcium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Vesicle Organization Tertiary Granule Organelle Localization By Membrane Tethering Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Central Nervous System Myelin Maintenance Membrane Docking Vesicle-mediated Transport Membrane Destabilizing Activity Positive Regulation Of Receptor Localization To Synapse Glycolipid Metabolic Process
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