EPM2A and EPM2AIP1

Number of citations of the paper that reports this interaction (PubMedID 12782127)
0

Data Source:
HPRD (in vivo)

		EPM2A	EPM2AIP1
Description		EPM2A glucan phosphatase, laforin	EPM2A interacting protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Dendrite Perikaryon Cytoplasmic Side Of Endoplasmic Reticulum Membrane Cytoplasmic Side Of Rough Endoplasmic Reticulum Membrane	Nucleus Cytoplasm Endoplasmic Reticulum Cytoplasmic Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Alpha-1,4-glucan Glucosyltransferase (UDP-glucose Donor) Activity Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity Carbohydrate Phosphatase Activity Carbohydrate Binding Polysaccharide Binding Identical Protein Binding Protein Homodimerization Activity Protein Dimerization Activity Glycogen Binding Starch Binding	Protein Binding Identical Protein Binding
	Biological Process	Autophagosome Assembly Regulation Of Cell Growth Glycogen Metabolic Process Glycogen Biosynthetic Process Protein Dephosphorylation Phosphate-containing Compound Metabolic Process Calcium Ion Transport Autophagy Mitochondrion Organization Nervous System Development Negative Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Phosphatase Activity Glial Cell Proliferation L-glutamate Transmembrane Transport Wnt Signaling Pathway Positive Regulation Of Macroautophagy Dephosphorylation Regulation Of Protein Ubiquitination Negative Regulation Of TOR Signaling Negative Regulation Of Dephosphorylation Peptidyl-tyrosine Dephosphorylation Regulation Of Protein Import Into Nucleus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle Carbohydrate Phosphorylation Habituation Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Localization To Plasma Membrane	Glycogen Biosynthetic Process Response To Insulin Positive Regulation Of Glycogen Biosynthetic Process
Pathways		Glycogen synthesis Myoclonic epilepsy of Lafora
Drugs
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Loneliness (multivariate analysis) ( 27629369) Mean platelet volume ( 27863252 32888494) Methadone dose in opioid dependence ( 28115739) Response to mepolizumab in severe asthma ( 29229094)	Autism spectrum disorder or schizophrenia ( 28540026) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Subjective response to lithium treatment ( 26503763) Triglyceride levels ( 32203549)
Interacting Genes		15 interacting genes: COX5A EIF2B1 EPM2AIP1 HMGXB4 NFU1 PKM PPP1R3C PPP1R3D PRKAA1 PRKAA2 PRKAB2 PSMC3 SRPK2 TDG TOPORS	47 interacting genes: ACTN1 APPL2 ARHGEF5 C1orf50 CBFA2T3 CCNB1IP1 CNTROB CPSF7 DTX3 EMP2 EPM2A FHL3 GFAP HSF2BP KCTD1 KCTD9 KRT16 KRT75 LDB2 LIN52 LNX1 MAD2L1 MEOX2 MX1 NOC4L OTUD7B PICK1 PRTFDC1 PSMA7 RBMY1F RBMY1J REL SERPINF1 SWSAP1 TFIP11 TNFAIP1 TNKS TRA2B TRIM50 TRIM54 USP54 VPS52 WEE2-AS1 ZBTB14 ZIM2 ZNF620 ZSCAN18
Entrez ID		7957	9852
HPRD ID		06345	07445
Ensembl ID		ENSG00000112425	ENSG00000178567
Uniprot IDs		O95278	Q7L775
PDB IDs		4R30 4RKK
Enriched GO Terms of Interacting Partners?		AMP-activated Protein Kinase Activity Regulation Of Generation Of Precursor Metabolites And Energy Nucleotide-activated Protein Kinase Complex Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Regulation Of Glycogen Biosynthetic Process Protein Localization To Lipid Droplet Generation Of Precursor Metabolites And Energy Regulation Of Glycogen Metabolic Process Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Carbohydrate Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Glycogen Metabolic Process Regulation Of Carbohydrate Catabolic Process Glycogen Binding Energy Reserve Metabolic Process Polysaccharide Metabolic Process Phosphatidylethanolamine Biosynthetic Process Regulation Of Protein Deacetylation Regulation Of Stress Granule Assembly Protein Phosphatase Type 1 Complex Fatty Acid Homeostasis Hepatocyte Apoptotic Process Glycogen Biosynthetic Process Cellular Response To Prostaglandin E Stimulus Response To Hormone Fatty Acid Biosynthetic Process Response To Glucose Chromatin Remodeling Polysaccharide Biosynthetic Process Phosphatidylcholine Biosynthetic Process Positive Regulation Of Glycolytic Process Protein Phosphatase 1 Binding Positive Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Prostaglandin Stimulus Response To Monosaccharide Protein K6-linked Ubiquitination Response To Prostaglandin E Negative Regulation Of Epithelial Cell Apoptotic Process Phosphatidylethanolamine Metabolic Process Positive Regulation Of Translation Positive Regulation Of Small Molecule Metabolic Process Response To Carbohydrate Macromolecule Metabolic Process Nuclear Speck Cholesterol Biosynthetic Process Positive Regulation Of ATP Metabolic Process	Identical Protein Binding Positive Regulation Of MRNA Splicing, Via Spliceosome
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