ABHD16A and LTA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ABHD16A	LTA
Description		abhydrolase domain containing 16A, phospholipase	lymphotoxin alpha
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Extracellular Region Extracellular Space Plasma Membrane Membrane
	Molecular Function	Phospholipase Activity Phosphatidylcholine Lysophospholipase Activity Protein Binding Hydrolase Activity Monoacylglycerol Lipase Activity	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding
	Biological Process	Lipid Metabolic Process Phosphatidylserine Catabolic Process Monoacylglycerol Catabolic Process Prostaglandin Catabolic Process	Response To Hypoxia Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Apoptotic Process Immune Response Humoral Immune Response Cell Communication Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Response To Nutrient Response To Xenobiotic Stimulus Signaling Response To Lipopolysaccharide Positive Regulation Of Type II Interferon Production Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Fibroblast Proliferation Lymph Node Development Defense Response To Gram-positive Bacterium Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs			Etanercept
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Monocyte percentage of white cells ( 32888494) Ulcerative colitis ( 28067908)	A body shape index ( 34021172) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 21102463) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Kawasaki disease ( 33106546) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Malaria ( 31844061) Monocyte count ( 32888494) Neonatal lupus ( 20662065) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Tumor necrosis factor levels ( 32805626) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 27863252)
Interacting Genes		69 interacting genes: AGPAT3 AQP6 AQP7 ATP5MC3 ATP5PF BRI3 CBARP CIDEB CREB3 CYP1A2 DNAJC1 DTX2 EBP ERGIC3 FDPS FKBP7 GDAP1 GJA5 GOLT1A GORAB GPR152 GPRC5C GYPC HM13 HNRNPA1 HSD17B13 IFITM1 IFITM3 ITGAM LTA MLH1 MT-ND3 MT-ND4 PERP PILRB PKMYT1 POLE PRAF2 PTGS2 RETREG3 RHBDD2 RHBDL1 RNF5 SAFB SEC22B SERF1A SERF1B SLC10A1 SLC30A2 SLC7A8 SPAG4 SPAG7 STMN4 STX1B TM4SF19 TMEM139 TMEM143 TMEM147 TMEM14B TMEM222 TMEM237 TMEM31 TMEM65 TSPAN2 UNC93A UPF1 VAMP5 VMA21 WBP1L	13 interacting genes: ABHD16A ASPH CREB3 LGALS2 LTB LTBR SLC30A2 TMEM237 TNFRSF14 TNFRSF1A TNFRSF1B TUBA4A UMOD
Entrez ID		7920	4049
HPRD ID		15929	01084
Ensembl ID		ENSG00000204427	ENSG00000226979
Uniprot IDs		A0A1U9X777 B3KNX9 O95870	P01374 Q5ST95 Q5STV3 Q6FG55
PDB IDs			1TNR 4MXV 4MXW
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Protein Binding Endoplasmic Reticulum	Tumor Necrosis Factor Receptor Activity Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Extracellular Matrix Constituent Secretion Pulmonary Valve Development Tumor Necrosis Factor Receptor Superfamily Complex Aortic Valve Development Semi-lunar Valve Development Positive Regulation Of Apoptotic Process Involved In Morphogenesis Tumor Necrosis Factor Binding Positive Regulation Of Apoptotic Process Involved In Development Regulation Of Extracellular Matrix Constituent Secretion Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Heart Valve Development Negative Regulation Of Extracellular Matrix Organization Cytokine-mediated Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Programmed Cell Death Negative Regulation Of Muscle Hypertrophy Regulation Of Muscle System Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Citric Acid Secretion Zinc Ion Import Into Zymogen Granule Zinc Ion Import Into Mitochondrion Zinc Ion Import Into Secretory Vesicle Positive Regulation Of Deacetylase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Peptidyl-aspartic Acid 3-dioxygenase Activity Plasma Membrane Membrane Galectin Complex Ubiquitin Protein Ligase Binding Cellular Response To Mechanical Stimulus Regulation Of Extracellular Matrix Organization Defense Response To Bacterium Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Cardiac Muscle Hypertrophy Metanephric Thick Ascending Limb Development Protein Transport Into Plasma Membrane Raft Micturition Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Negative Regulation Of Adaptive Immune Memory Response Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Signaling Pathway Response To Unfolded Protein Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Juxtaglomerular Apparatus Development Defense Response To Gram-negative Bacterium
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