TMEM243 and ELOVL5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM243	ELOVL5
Description		transmembrane protein 243	ELOVL fatty acid elongase 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Dendrite Cell Projection Neuronal Cell Body Dendritic Tree
	Molecular Function	Protein Binding	Protein Binding Fatty Acid Elongase Activity Transferase Activity
	Biological Process		Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Fatty Acid Elongation, Saturated Fatty Acid Sphingolipid Biosynthetic Process Fatty Acid Elongation Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongation, Polyunsaturated Fatty Acid Long-chain Fatty-acyl-CoA Biosynthetic Process Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Very Long-chain Fatty Acid Biosynthetic Process Linoleic Acid Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Fatty Acid Derivative Biosynthetic Process
Pathways			Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism Synthesis of very long-chain fatty acyl-CoAs MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs			alpha-Linolenic acid
Diseases
GWAS		Lung cancer in never smokers ( 28604730) Schizophrenia ( 29483656)	Cerebrospinal fluid AB1-42 levels ( 26252872) Daytime sleep phenotypes ( 27126917) Familial squamous cell lung carcinoma ( 29924316) Glaucoma ( 20363506) Lymphocyte count ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Red cell distribution width ( 32888494) Survival in colorectal cancer (distant metastatic) ( 26586795)
Interacting Genes		46 interacting genes: AQP6 BIK CD33 CD74 CD79A CISD2 CLEC14A CPLX4 CREB3 EBP ELOVL4 ELOVL5 ERGIC3 FAM174A FAM209A FFAR2 GJA8 GPR108 GPR152 GPR37L1 GPX8 HSD17B13 JAGN1 KIR2DL3 LIME1 LMNA LRP10 MRM1 MTIF3 MUC1 PLP1 PSCA RETREG3 RMDN3 SAR1A SCN3B SEC11C SLC10A6 SSMEM1 TMEM101 TMEM14B TMEM35A TMEM45B TMEM80 TMPRSS2 ZFYVE27	14 interacting genes: GOSR2 HMOX1 HTR4 IGFBP5 NINJ2 PLP2 SLC39A9 STX7 SYNJ2BP SYS1 THSD7A TMEM243 TSNARE1 UBC
Entrez ID		79161	60481
HPRD ID		12911	13268
Ensembl ID		ENSG00000135185	ENSG00000012660
Uniprot IDs		C9JY04 Q9BU79	A0A0A0MTI6 B3KWH9 Q9NYP7
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum B Cell Receptor Complex Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Acetylcholine Receptor Regulator Activity Protein Binding Unsaturated Fatty Acid Biosynthetic Process Fatty Acid Elongation, Saturated Fatty Acid Negative Regulation Of Peptide Secretion Fatty Acid Biosynthetic Process Very Long-chain Fatty Acid Biosynthetic Process Endoplasmic Reticulum Organization Fatty Acid Elongation	SNARE Complex SNAP Receptor Activity SNARE Binding Membrane Organelle Membrane Fusion Vesicle Fusion Organelle Fusion Regulation Of Endothelial Cell Proliferation Membrane Fusion Mitochondrial Outer Membrane Large Intestinal Transit Negative Regulation Of Skeletal Muscle Hypertrophy Negative Regulation Of Smooth Muscle Cell Proliferation Heme Oxidation Smooth Muscle Hyperplasia Heme Oxygenase (decyclizing) Activity Wound Healing Involved In Inflammatory Response Endomembrane System Vesicle Docking Regulation Of Cellular Response To Testosterone Stimulus Zinc Efflux Transmembrane Transporter Activity Organelle Localization By Membrane Tethering Vesicle Organization Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Cell Motility Negative Regulation Of Cell Migration Insulin-like Growth Factor Binding Protein Complex Membrane Docking Tertiary Granule Establishment Of Protein Localization Regulation Of Epithelial Cell Proliferation Cellular Response To Cisplatin Negative Regulation Of Locomotion Insulin-like Growth Factor Ternary Complex Membrane Destabilizing Activity Positive Regulation Of Receptor Localization To Synapse
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