DERL1 and AMFR

Number of citations of the paper that reports this interaction (PubMedID 32614325)
136

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down)

		DERL1	AMFR
Description		derlin 1	autocrine motility factor receptor
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GO Annotations	Cellular Component	Early Endosome Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Derlin-1-VIMP Complex Derlin-1 Retrotranslocation Complex Endoplasmic Reticulum Quality Control Compartment	Ubiquitin Ligase Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Dendrite Growth Cone Protein-containing Complex Derlin-1 Retrotranslocation Complex Neuronal Cell Body Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm
	Molecular Function	Protease Binding Signal Recognition Particle Binding Protein Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity MHC Class I Protein Binding Identical Protein Binding Protein-containing Complex Binding ATPase Binding Ubiquitin-specific Protease Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein-macromolecule Adaptor Activity Ubiquitin-ubiquitin Ligase Activity Signaling Receptor Activity Identical Protein Binding Ubiquitin Binding Metal Ion Binding Protein-folding Chaperone Binding Ubiquitin Protein Ligase Activity BAT3 Complex Binding Ubiquitin-specific Protease Binding
	Biological Process	Response To Unfolded Protein Proteasomal Protein Catabolic Process Protein Transport Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Positive Regulation Of Protein Ubiquitination Protein Destabilization Cellular Response To Stress Cellular Response To Unfolded Protein ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization Cellular Response To Misfolded Protein	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Signal Transduction Canonical NF-kappaB Signal Transduction Learning Or Memory Wnt Signaling Pathway Protein Ubiquitination Endoplasmic Reticulum Unfolded Protein Response ERAD Pathway Non-canonical NF-kappaB Signal Transduction Protein K27-linked Ubiquitination Protein Autoubiquitination Protein K48-linked Ubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Endoplasmic Reticulum Mannose Trimming Regulation Of SREBP Signaling Pathway
Pathways		ABC-family proteins mediated transport N-glycan trimming in the ER and Calnexin/Calreticulin cycle Defective CFTR causes cystic fibrosis E3 ubiquitin ligases ubiquitinate target proteins AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	N-glycan trimming in the ER and Calnexin/Calreticulin cycle ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS		Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483)	Apolipoprotein A1 levels ( 32203549) Breast cancer ( 29059683)
Interacting Genes		32 interacting genes: ABHD4 AMFR APP AQP6 CFTR CIAO2A FCRL4 FFAR2 GAD2 HLA-A KASH5 LMNA LNX1 MELTF REEP4 RETREG3 RHO SCN3B SELENOS SLC10A1 SLC10A6 SLC30A8 SLC7A14 SLC7A8 TCF25 TEX44 TMED8 TMEM31 TMX2 TRIM32 UBXN6 VCP	34 interacting genes: BAG6 CNOT1 CRMP1 CSNK2A2 CYP2E1 DERL1 DHFR GPI HERPUD1 HTT KPNB1 MGRN1 PPP1R13L RETREG1 SOD1 TAB3 TMCO1 TOM1L1 TRIM25 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2G2 UBE2K UBE2N UBE2T UBE2W UBL4A UFD1 USP13 VCP
Entrez ID		79139	267
HPRD ID		12302	09130
Ensembl ID		ENSG00000136986	ENSG00000159461
Uniprot IDs		E5RGY0 Q9BUN8	Q9UKV5
PDB IDs		5GLF 7CZB 7Y4W 7Y53 7Y59	2EJS 2LVN 2LVO 2LVP 2LVQ 2LXH 2LXP 3FSH 3H8K 3TIW 4G3O 4LAD 8T0S
Enriched GO Terms of Interacting Partners?		Derlin-1 Retrotranslocation Complex Ubiquitin-specific Protease Binding BAT3 Complex Binding ERAD Pathway Bile Acid:sodium Symporter Activity Response To Endoplasmic Reticulum Stress Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Endoplasmic Reticulum Membrane Endoplasmic Reticulum Endoplasmic Reticulum Unfolded Protein Response Protein Binding Membrane Positive Regulation Of Chemokine Production Low-density Lipoprotein Particle Organic Anion Transport Golgi-associated Vesicle Membrane Retrograde Protein Transport, ER To Cytosol Early Endosome Membrane Positive Regulation Of Proteolysis Positive Regulation Of Insulin Secretion Very-low-density Lipoprotein Particle Endoplasmic Reticulum Tubular Network Organization Bile Acid And Bile Salt Transport Endoplasmic Reticulum Tubular Network	Ubiquitin Conjugating Enzyme Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Catabolic Process Ubiquitin-protein Transferase Activity Proteolysis Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Ubiquitin Protein Ligase Binding Post-translational Protein Modification Protein Modification By Small Protein Conjugation Proteasomal Protein Catabolic Process ERAD Pathway Protein Monoubiquitination Protein Catabolic Process Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Misfolded Protein Protein Metabolic Process Response To Misfolded Protein Response To Endoplasmic Reticulum Stress Retrograde Protein Transport, ER To Cytosol Cytosol Cellular Response To Stress Cellular Response To Topologically Incorrect Protein Macromolecule Metabolic Process Protein Exit From Endoplasmic Reticulum Protein K11-linked Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of ERAD Pathway Ubiquitin-like Protein Transferase Activity Ubiquitin-specific Protease Binding ATP Binding Negative Regulation Of Signal Transduction BAT3 Complex Transferase Activity Protein K63-linked Ubiquitination Regulation Of ERAD Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein K6-linked Ubiquitination Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process BAT3 Complex Binding Maintenance Of Unfolded Protein Regulation Of Ubiquitin-dependent Protein Catabolic Process
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