PRRG4 and CYGB

		PRRG4	CYGB
Description		proline rich and Gla domain 4	cytoglobin
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Nucleus Cytoplasm Cytosol Nuclear Speck Neuron Projection Neuronal Cell Body
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding WW Domain Binding	Catalase Activity Peroxidase Activity Superoxide Dismutase Activity Oxygen Carrier Activity Iron Ion Binding Protein Binding Antioxidant Activity Oxidoreductase Activity Oxygen Binding Heme Binding Metal Ion Binding Fatty Acid Peroxidase Activity Carbon Monoxide Binding Nitrite Reductase Activity Nitric Oxide Dioxygenase Activity, Heme Protein As Donor
	Biological Process	Proteolysis Blood Coagulation	Response To Hypoxia Response To Oxidative Stress Negative Regulation Of Fibroblast Migration Oxygen Transport Fatty Acid Oxidation Removal Of Superoxide Radicals Negative Regulation Of Collagen Biosynthetic Process Nitric Oxide Metabolic Process Nitric Oxide Catabolic Process Negative Regulation Of Hepatic Stellate Cell Activation
Pathways			eNOS activation Intracellular oxygen transport
Drugs
Diseases
GWAS		Parkinson's disease (age of onset) ( 19772629) Platelet count ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		31 interacting genes: ABL2 AOC3 ARHGEF7 BCL10 CYGB ERBB3 ERBB4 FYN GRAP GRB2 HCK HDAC1 HECW1 HLA-C ITCH ITSN1 LYN MAGI2 MAGI3 NEBL NEDD4 OSTF1 PEX13 RBBP8 TEC UBE2K VAV2 VEGFA WWP1 WWTR1 YAP1	11 interacting genes: ARHGAP8 ATP13A2 CD300C DDI1 FAAP100 LRATD1 MZT1 PRR5-ARHGAP8 PRRG4 TBC1D16 WBP11
Entrez ID		79056	114757
HPRD ID		15187	06479
Ensembl ID		ENSG00000135378	ENSG00000161544
Uniprot IDs		A0A0S2Z5M6 A0A0S2Z5N9 Q9BZD6	Q8WWM9
PDB IDs			1UMO 1URV 1URY 1UT0 1UX9 1V5H 2DC3 3AG0 4B3W
Enriched GO Terms of Interacting Partners?		Signal Transduction Intracellular Signal Transduction Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Signal Transduction Positive Regulation Of Immune System Process Fc Receptor Mediated Stimulatory Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Immune Response Immune Response-activating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Modification Process Epidermal Growth Factor Receptor Binding Fc-gamma Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Activation Of Immune Response Regulation Of Cell Communication Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Cytoplasm Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Fc Receptor Signaling Pathway Regulation Of Immune Response Proline-rich Region Binding Epidermal Growth Factor Receptor Signaling Pathway Cytosol Antigen Receptor-mediated Signaling Pathway Regulation Of Cell Adhesion Plasma Membrane Neuregulin Receptor Activity Regulation Of Neuron Projection Development Regulation Of Immune System Process Protein Ubiquitination ERBB Signaling Pathway Regulation Of Cell Activation Adaptive Immune Response Positive Regulation Of Defense Response Receptor-mediated Endocytosis Negative Regulation Of Apoptotic Process	WW Domain Binding Spermine Transmembrane Transport ABC-type Polyamine Transporter Activity Microtubule Nucleation By Interphase Microtubule Organizing Center
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