ALG8 and RSF1

		ALG8	RSF1
Description		ALG8 alpha-1,3-glucosyltransferase	remodeling and spacing factor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Lumenal Side Of Endoplasmic Reticulum Membrane	Chromatin Nucleus Nucleoplasm RSF Complex
	Molecular Function	Dolichyl-phosphate-glucose-glycolipid Alpha-glucosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Hexosyltransferase Activity Dolichyl Pyrophosphate Glc1Man9GlcNAc2 Alpha-1,3-glucosyltransferase Activity	Protein Binding Zinc Ion Binding ATP Hydrolysis Activity Histone Binding Metal Ion Binding Histone Octamer Slider Activity
	Biological Process	Protein Glycosylation Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Protein N-linked Glycosylation Via Asparagine	Chromatin Organization Nucleosome Assembly Chromatin Remodeling DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Negative Regulation Of DNA Binding Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Viral Transcription
Pathways		Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG8 causes CDG-1h	Deposition of new CENPA-containing nucleosomes at the centromere
Drugs
Diseases		Congenital disorders of glycosylation (CDG) type I
GWAS		Depression in smokers ( 30219690) Femur bone mineral density x serum urate levels interaction ( 34046847) Tourette syndrome ( 30818990)	Left-handedness ( 32989287) Tourette syndrome ( 30818990)
Interacting Genes		16 interacting genes: BIK CLRN1 CREB3 CREB3L1 CYB5R3 FAM209A GPX8 IQGAP2 LMNA MFSD6 NAE1 NARS2 RPS6KA5 RSF1 SAR1A TMEM126B	8 interacting genes: ALG8 CDK1 CSNK2A1 HMGB1 NFKB1 PLK1 SMARCA5 TENM4
Entrez ID		79053	51773
HPRD ID		10480	10537
Ensembl ID		ENSG00000159063	ENSG00000048649
Uniprot IDs		A0A024R5K5 A0A7P0TA89 A0A7P0TAA8 A0A7P0Z449 A0A804G6E3 E9PR58 H0YCV0 H0YD42 H0YDD3 H0YEE0 Q9BVK2	Q05DG0 Q96T23
PDB IDs
Enriched GO Terms of Interacting Partners?			Protein Localization To Site Of Double-strand Break Regulation Of DNA Metabolic Process DNA Repair Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Cell Cycle Process Mitotic Nuclear Membrane Disassembly DNA Metabolic Process Protein Localization To Chromosome DNA Damage Response Negative Regulation Of Cell Cycle DNA Damage Checkpoint Signaling Nuclear Membrane Disassembly Membrane Disassembly Regulation Of Chromosome Segregation Signal Transduction In Response To DNA Damage Negative Regulation Of Gene Expression Nucleic Acid Metabolic Process Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Mitotic G2 DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Double-strand Break Repair Condensed Chromosome Chromosome Condensation Regulation Of DNA Repair DNA Recombination Spindle Microtubule Regulation Of Chromosome Organization Positive Regulation Of DNA Replication Negative Regulation Of Double-strand Break Repair Negative Regulation Of DNA Repair Regulation Of Apoptotic Process Nucleobase-containing Compound Metabolic Process Nuclear Membrane Organization Regulation Of Transcription By RNA Polymerase II Centrosome Cycle Positive Regulation Of DNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Macromolecule Biosynthetic Process Regulation Of Programmed Cell Death Regulation Of Cell Cycle Process G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA Recombination Mitotic G2/M Transition Checkpoint Cellular Response To Stress Cell Cycle G2/M Phase Transition Negative Regulation Of Metabolic Process Pronuclear Fusion
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