ZFYVE21 and PYCARD

Number of citations of the paper that reports this interaction (PubMedID 37225719)
40

Data Source:
BioGRID (pull down)

		ZFYVE21	PYCARD
Description		zinc finger FYVE-type containing 21	PYD and CARD domain containing
Image
GO Annotations	Cellular Component	Endosome Focal Adhesion Cytoplasmic Vesicle Anchoring Junction	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol Microtubule IkappaB Kinase Complex Membrane Protein-containing Complex Secretory Granule Lumen Azurophil Granule Lumen Neuronal Cell Body Canonical Inflammasome Complex NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex NLRP6 Inflammasome Complex
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Protease Binding Interleukin-6 Receptor Binding Protein Binding Tropomyosin Binding Myosin I Binding Enzyme Binding Pyrin Domain Binding Pattern Recognition Receptor Activity Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding Protein Dimerization Activity BMP Receptor Binding Cysteine-type Endopeptidase Activator Activity
	Biological Process		Myeloid Dendritic Cell Activation Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Defense Response To Virus By Host Myeloid Dendritic Cell Activation Involved In Immune Response Immune System Process Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Adaptive Immune Response Apoptotic Process Inflammatory Response Signal Transduction Osmosensory Signaling Pathway Response To Bacterium Regulation Of Autophagy Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Actin Filament Polymerization Regulation Of Protein Stability Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interferon-beta Production Positive Regulation Of Chemokine Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Defense Response To Bacterium Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Macropinocytosis NLRP3 Inflammasome Complex Assembly Innate Immune Response Positive Regulation Of JNK Cascade Icosanoid Biosynthetic Process Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of T Cell Activation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Defense Response To Virus Positive Regulation Of Macrophage Cytokine Production Pyroptotic Inflammatory Response Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Negative Regulation Of Protein Serine/threonine Kinase Activity Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Canonical Inflammasome Complex Assembly Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of T Cell Migration Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			CLEC7A/inflammasome pathway Neutrophil degranulation The NLRP3 inflammasome The AIM2 inflammasome Purinergic signaling in leishmaniasis infection SARS-CoV-1 activates/modulates innate immune responses
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 26426971) Hemoglobin ( 32888494) Schizophrenia ( 25056061 29483656)	Post bronchodilator FEV1 ( 26634245)
Interacting Genes		28 interacting genes: AGTRAP ARL6IP1 CAPN2 CMTM4 FBXO7 KRT31 KRT38 KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP5-9 MID2 MTUS2 NOTCH2NLA PDE4DIP PTK2 PYCARD RABAC1 REEP6 RTN4 RUBCN SIAH1 SMIM5 TRAF1 TRIM27 TUBB YIF1A	15 interacting genes: CASP1 EXOC5 MEFV NLRC4 NLRP1 NLRP12 NLRP3 POP1 PRKAR1A PYDC2 RUBCN SRF USP3 USP50 ZFYVE21
Entrez ID		79038	29108
HPRD ID		15733	06020
Ensembl ID		ENSG00000100711	ENSG00000103490
Uniprot IDs		Q9BQ24	Q9ULZ3
PDB IDs		2RRF	1UCP 2KN6 3J63 5H8O 6K99 6KI0 6N1H 7E5B 7KEU
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Endoplasmic Reticulum Tubular Network Formation Identical Protein Binding Phosphatidylinositol 3-kinase Inhibitor Activity Endoplasmic Reticulum Tubular Network Membrane Organization Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Endoplasmic Reticulum Organization Structural Molecule Activity Intermediate Filament Organization Vascular Endothelial Cell Response To Fluid Shear Stress Negative Regulation Of Viral Transcription Regulation Of Autophagy Endoplasmic Reticulum Membrane Organization Suppression Of Viral Release By Host Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Regulation Of Viral Transcription Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Mononuclear Cell Migration Endoplasmic Reticulum Tubular Network Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of Macrophage Migration Regulation Of Apoptotic Process Cellular Response To Fluid Shear Stress Regulation Of Cytoskeleton Organization Cytosol Ubiquitin Protein Ligase Binding Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Myosin I Binding Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Negative Regulation Of Vasculogenesis Positive Regulation Of ERBB3 Signaling Pathway Cell Adhesion Involved In Sprouting Angiogenesis Regulation Of Mononuclear Cell Migration Cytoskeleton Positive Regulation Of Leukocyte Migration Regulation Of Macrophage Cytokine Production Regulation Of Programmed Cell Death Microtubule Response To Fluid Shear Stress	Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Canonical Inflammasome Complex Pyroptotic Inflammatory Response Regulation Of Interleukin-18 Production Positive Regulation Of Inflammatory Response NLRP3 Inflammasome Complex Regulation Of Inflammatory Response Negative Regulation Of Interleukin-1 Production Regulation Of NLRP3 Inflammasome Complex Assembly Cysteine-type Endopeptidase Activator Activity Positive Regulation Of Interleukin-18 Production Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Defense Response IPAF Inflammasome Complex Regulation Of Defense Response Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Inflammatory Response Positive Regulation Of Innate Immune Response Immune System Process Immune Response-activating Signaling Pathway NLRP1 Inflammasome Complex Negative Regulation Of Inflammatory Response Regulation Of DNA-binding Transcription Factor Activity Osmosensory Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Innate Immune Response Positive Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Positive Regulation Of Gene Expression Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Interleukin-18-mediated Signaling Pathway Pyroptotic Cell Death Negative Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Defense Response Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Innate Immune Response Negative Regulation Of Cytokine Production Positive Regulation Of Immune Response Cysteine-type Peptidase Activity Response To Other Organism
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