CYREN and ERCC6L2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		CYREN	ERCC6L2
Description		cell cycle regulator of NHEJ	ERCC excision repair 6 like 2
Image
GO Annotations	Cellular Component	Nucleus Chromosome Cytoplasm Site Of Double-strand Break DNA Repair Complex	Chromosome, Centromeric Region Nucleus Chromosome Cytoplasm Mitochondrion Centrosome Cytoskeleton Protein-containing Complex
	Molecular Function	Damaged DNA Binding Protein Binding	Nucleotide Binding DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity Protein Kinase Binding
	Biological Process	DNA Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response Immunoglobulin V(D)J Recombination Protein Localization To Site Of Double-strand Break Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	DNA Repair DNA Damage Response Cellular Response To Reactive Oxygen Species Interstrand Cross-link Repair Double-strand Break Repair Via Classical Nonhomologous End Joining
Pathways
Drugs
Diseases
GWAS			Adult body size ( 32376654) Glucagon levels in response to oral glucose tolerance test (decremental area under the curve for 0-30 minutes) ( 33407418) Hip circumference adjusted for BMI ( 34021172) Monobrow ( 27182965) Parkinson's disease (pesticide exposure interaction) ( 27545685) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		5 interacting genes: ATM ERCC6L2 LRRK2 MFHAS1 MKLN1	3 interacting genes: CYREN NEK6 TCP11L1
Entrez ID		78996	375748
HPRD ID		08333	17362
Ensembl ID		ENSG00000122783	ENSG00000182150
Uniprot IDs		Q9BWK5	A0A590UJ12 A0A590UJA1 A0A590UJK0 A0A5F9UKL4 A0A804HJ75 A0A804HK79 A0AAQ5BIG0 Q5T890
PDB IDs		6TYU	6HQ9 8COB
Enriched GO Terms of Interacting Partners?		Cellular Response To Reactive Oxygen Species Response To Reactive Oxygen Species Cellular Response To Oxidative Stress Cellular Response To Chemical Stress Determination Of Adult Lifespan Regulation Of Vacuole Organization Regulation Of Autophagosome Assembly Double-strand Break Repair Via Nonhomologous End Joining Response To Oxidative Stress Regulation Of Macrophage Activation Establishment Of RNA Localization To Telomere Cytoskeleton Regulation Of Cell Activation Establishment Of Protein-containing Complex Localization To Telomere Protein Autophosphorylation Positive Regulation Of Telomerase Catalytic Core Complex Assembly Nucleotide Binding Postsynaptic Endosome Membrane Postsynaptic Specialization Membrane Of Symmetric Synapse Neurotransmitter Receptor Transport Postsynaptic Membrane To Endosome Cellular Response To Curcumin Caveola Neck Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion GTP-dependent Protein Kinase Activity Beta-catenin Destruction Complex Binding Wnt Signalosome Assembly DNA-dependent Protein Kinase Activity Histone H2AXS139 Kinase Activity Positive Regulation Of Protein Autoubiquitination Response To Curcumin Vacuole Organization Positive Regulation Of Autophagy Cellular Response To Nitrosative Stress Pre-B Cell Allelic Exclusion Cellular Response To Oxygen-containing Compound Peptidyl-serine Autophosphorylation Regulation Of Macroautophagy Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Cytoplasmic Side Of Mitochondrial Outer Membrane Positive Regulation Of Dopamine Receptor Signaling Pathway Multivesicular Body, Internal Vesicle Regulation Of CAMKK-AMPK Signaling Cascade Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Synaptic Vesicle Transport Double-strand Break Repair Response To Starvation Postsynapse
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