MAPKAPK3 and RCSD1

Number of citations of the paper that reports this interaction (PubMedID 15850461)
32

Data Source:
BioGRID (enzymatic study)

		MAPKAPK3	RCSD1
Description		MAPK activated protein kinase 3	RCSD domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Early Endosome Cytosol Actin Filament WASH Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity MAP Kinase Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity	Actin Filament Binding Phosphatidylinositol Phosphate Binding Retromer Complex Binding
	Biological Process	MAPK Cascade Toll-like Receptor Signaling Pathway Signal Transduction Response To Lipopolysaccharide Response To Cytokine Intracellular Signal Transduction Macropinocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway	Skeletal Muscle Contraction Protein Localization To Endosome Retrograde Transport, Endosome To Golgi Cellular Hyperosmotic Response
Pathways		p38MAPK events Oxidative Stress Induced Senescence VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation
Drugs		2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cortical surface area (MOSTest) ( 32665545) Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) High light scatter reticulocyte count ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Asthma ( 31959851) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		22 interacting genes: APP ATF1 BECN1 CHMP2A COPS6 EEF2 EEF2K EZH2 HSPB1 IGHM LINC02582 MAPK13 MAPK14 NEDD4 NEDD4L RAB2A RCSD1 SMS SRPK2 SUMO3 TCF3 THAP12	3 interacting genes: MAPK12 MAPKAPK2 MAPKAPK3
Entrez ID		7867	92241
HPRD ID		03678	10077
Ensembl ID		ENSG00000114738	ENSG00000198771
Uniprot IDs		Q16644	B7ZKW8 Q6JBY9
PDB IDs		3FHR 3FXW 3R1N 3SHE 7NRB
Enriched GO Terms of Interacting Partners?		Response To Growth Factor Cellular Response To Growth Factor Stimulus Receptor Catabolic Process Response To Hydrogen Peroxide Regulation Of Dendrite Development Response To Nerve Growth Factor Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Potassium Ion Export Across Plasma Membrane Receptor Metabolic Process Regulation Of Synapse Organization Response To Metal Ion Positive Regulation Of Cell Cycle Response To Reactive Oxygen Species Sodium Channel Inhibitor Activity Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Dendrite Morphogenesis Potassium Channel Inhibitor Activity Cellular Response To Hydrogen Peroxide Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Plasma Membrane Bounded Cell Projection Organization Response To Stress Negative Regulation Of Sodium Ion Transport Regulation Of Cell Projection Organization Regulation Of Neuron Projection Development Cellular Response To UV MAP Kinase Activity Response To Lead Ion Regulation Of Cell Cycle Positive Regulation Of Cellular Component Organization Positive Regulation Of Metabolic Process Protein Metabolic Process Regulation Of Protein Metabolic Process Response To Other Organism Cellular Response To Copper Ion Cellular Response To Light Stimulus Stress-activated MAPK Cascade Cellular Response To Reactive Oxygen Species Cellular Response To Chemical Stress Negative Regulation Of Potassium Ion Transmembrane Transport Intracellular Transport Cytosol Positive Regulation Of Transport Vesicle-mediated Transport Cellular Response To Stress P38MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Viral Budding Lysosomal Transport Intracellular Signaling Cassette Extracellular Exosome	Macropinocytosis Calcium-dependent Protein Serine/threonine Kinase Activity Pinocytosis MAPK Cascade Calcium/calmodulin-dependent Protein Kinase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Kinase Activity Toll-like Receptor Signaling Pathway Kinase Activity Intracellular Signaling Cassette Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Calmodulin Binding Activation Of Innate Immune Response ATP Binding Nucleotide Binding Transferase Activity Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide Immune Response-activating Signaling Pathway Peptidase Activator Activity Immune Response-regulating Signaling Pathway Activation Of Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Endocytosis Regulation Of Innate Immune Response Positive Regulation Of Defense Response MAP Kinase Kinase Activity Regulation Of Cellular Response To Heat MAP Kinase Activity Response To Cytokine Response To Peptide 3'-UTR-mediated MRNA Stabilization Import Into Cell Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of Immune Response P38MAPK Cascade Cellular Response To Vascular Endothelial Growth Factor Stimulus Leukotriene Metabolic Process Myoblast Differentiation DNA Damage Response Response To Lipid Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Regulation Of Defense Response
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