NPHS2 and FOXC2

Number of citations of the paper that reports this interaction (PubMedID 24854274)
48

Data Source:
BioGRID (pull down)

		NPHS2	FOXC2
Description		NPHS2 stomatin family member, podocin	forkhead box C2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Cell-cell Junction Cytoplasmic Side Of Plasma Membrane Membrane Protein-containing Complex Slit Diaphragm Membrane Raft Extracellular Exosome Cell Periphery	Chromatin Nucleus Nucleoplasm Nuclear Body
	Molecular Function	Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Chromatin DNA Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Glomerular Filtration Gene Expression Actin Cytoskeleton Organization Renal System Development Metanephric Podocyte Development	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Ossification Blood Vessel Development Branching Involved In Blood Vessel Morphogenesis Metanephros Development Ureteric Bud Development Somitogenesis Kidney Development Lymph Vessel Development Lymphangiogenesis Blood Vessel Remodeling Heart Morphogenesis Apoptotic Process Involved In Outflow Tract Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Mesoderm Development Heart Development Cell Population Proliferation Insulin Receptor Signaling Pathway Anatomical Structure Morphogenesis Response To Hormone Positive Regulation Of Endothelial Cell Migration Neural Crest Cell Development Cell Differentiation Collagen Fibril Organization Positive Regulation Of Cell Adhesion Mediated By Integrin Embryonic Heart Tube Development Positive Regulation Of Vascular Wound Healing Camera-type Eye Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Organ Growth Vascular Endothelial Growth Factor Receptor Signaling Pathway Paraxial Mesoderm Formation Paraxial Mesodermal Cell Fate Commitment Embryonic Cranial Skeleton Morphogenesis Embryonic Viscerocranium Morphogenesis Embryonic Skeletal System Morphogenesis Artery Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Proliferation Glomerular Endothelium Development Podocyte Differentiation Glomerular Mesangial Cell Development Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Blood Vessel Diameter Maintenance Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Apoptotic Process Involved In Outflow Tract Morphogenesis
Pathways		Nephrin family interactions	Formation of intermediate mesoderm Formation of the ureteric bud
Drugs
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis	Lymphedemas, including: Lymphedema, hereditary I; Lymphedema-distichiasis syndrome (LD); Hypotrichosis-lymphedema-telangiectasia syndrome (HLTS)
GWAS			Metabolite levels ( 23823483) Nonsyndromic cleft palate ( 31609978) Nose size ( 27182965) Sepsis in extremely premature infants ( 28283553) Systemic juvenile idiopathic arthritis ( 27927641)
Interacting Genes		7 interacting genes: CD2AP FOXC1 FOXC2 KIRREL1 KIRREL3 LMX1B NPHS1	8 interacting genes: CNOT7 GOLGA2 KRTAP3-3 METTL27 NPHS2 RBPMS TAX1BP1 TRIM27
Entrez ID		7827	2303
HPRD ID		05303	03869
Ensembl ID		ENSG00000116218	ENSG00000176692
Uniprot IDs		Q9NP85	Q99958
PDB IDs			1D5V 6AKO 6AKP 6LBM 6O3T
Enriched GO Terms of Interacting Partners?		Apoptotic Process Involved In Outflow Tract Morphogenesis Negative Regulation Of Apoptotic Process Involved In Outflow Tract Morphogenesis Regulation Of Apoptotic Process Involved In Outflow Tract Morphogenesis Cell-cell Junction Apoptotic Process Involved In Heart Morphogenesis Glomerular Epithelium Development Paraxial Mesoderm Formation Renal Protein Absorption Slit Diaphragm Cell Adhesion Molecule Binding Lymph Vessel Development Endothelium Development Podocyte Differentiation Cell Junction Organization Cell-cell Adhesion Kidney Development Embryonic Heart Tube Development Apoptotic Process Involved In Morphogenesis Cell-cell Junction Organization Myosin Binding Neural Crest Cell Development Cardiac Muscle Cell Proliferation Cell Differentiation Involved In Kidney Development Apoptotic Process Involved In Development Stem Cell Development Vascular Endothelial Growth Factor Receptor Signaling Pathway Epithelium Development Extracellular Matrix Organization Tissue Development Extracellular Structure Organization Ureteric Bud Development Dendritic Shaft Blood Vessel Remodeling Regionalization Renal Absorption Cellular Developmental Process Muscle Cell Proliferation Ventricular Cardiac Muscle Tissue Morphogenesis Mesoderm Formation Somitogenesis Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Actin Filament Polymerization Segmentation Cell Adhesion Cell Development Heart Morphogenesis Cardiac Muscle Tissue Morphogenesis Formation Of Primary Germ Layer Regulation Of Actin Cytoskeleton Organization
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