ZNF10 and SRY

Number of citations of the paper that reports this interaction (PubMedID 19850934)
36

Data Source:
BioGRID (pull down)

		ZNF10	SRY
Description		zinc finger protein 10	sex determining region Y
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Protein-containing Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Speck
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Calmodulin Binding DNA-binding Transcription Factor Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Regulation Of Transcription By RNA Polymerase II Sex Differentiation Positive Regulation Of Gene Expression Cell Differentiation Male Sex Determination Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Male Gonad Development
Pathways		Generic Transcription Pathway	Deactivation of the beta-catenin transactivating complex Transcriptional regulation of testis differentiation
Drugs
Diseases			46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Refractive error ( 32231278)
Interacting Genes		7 interacting genes: CARD10 CBX3 GOLGA3 NDEL1 SRY TRIM24 TRIM28	11 interacting genes: AR EP300 HDAC3 KAT8 KPNB1 NHERF2 SMAD3 ZNF10 ZNF208 ZNF274 ZNF354C
Entrez ID		7556	6736
HPRD ID		01923	08364
Ensembl ID		ENSG00000256223	ENSG00000184895
Uniprot IDs		P21506	A7WPU8 Q05066
PDB IDs			1HRY 1HRZ 1J46 1J47 2GZK 6EDB 7YHO 7YHP 7YHQ 9BVD
Enriched GO Terms of Interacting Partners?		Euchromatin Heterochromatin Chromatin Histone H3K23ac Reader Activity Chromatin Binding Perichromatin Fibrils Regulation Of Intracellular Protein Transport Convergent Extension Involved In Axis Elongation Ubiquitin-like Protein Ligase Activity Negative Regulation Of Gene Expression, Epigenetic Krueppel-associated Box Domain Binding Heterochromatin Formation Positive Regulation Of Protein Localization To Nucleus Embryonic Placenta Morphogenesis Chromo Shadow Domain Binding Regulation Of Protein Localization To Nucleus RNA Polymerase II Transcription Regulator Complex Chromosome, Centromeric Region Senescence-associated Heterochromatin Focus Chromatin Lock Complex CBM Complex Radial Glia-guided Pyramidal Neuron Migration Neurofilament Cytoskeleton Mitotic Centrosome Separation	Zinc Ion Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Beta-catenin Binding Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Protein Propionyltransferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Import Into Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding DNA-binding Transcription Factor Binding Transcription Coactivator Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA Binding Chromatin Binding Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleus Membraneless Organelle Assembly Regulation Of Gene Expression Chromatin DNA Binding Positive Regulation Of Intracellular Protein Transport Regulation Of Macromolecule Biosynthetic Process Histone H4 Acetyltransferase Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Protein Localization To Nucleus Organelle Assembly Negative Regulation Of Metabolic Process Regulation Of Nucleocytoplasmic Transport Acetyltransferase Activity Regulation Of Macromolecule Metabolic Process Positive Regulation Of Intracellular Transport Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Regulation Of Intracellular Protein Transport Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity Regulation Of Protein Localization To Nucleus Histone Acetyltransferase Activity NF-kappaB Binding Regulation Of Metabolic Process Regulation Of Cellular Localization
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