ZIC3 and DNAI1

		ZIC3	DNAI1
Description		Zic family zinc finger 3	dynein axonemal intermediate chain 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Extracellular Region Cytoplasm Centrosome Cytoskeleton Microtubule Cilium Microtubule Cytoskeleton Dynein Complex Outer Dynein Arm Cell Projection Glial Cell Projection 9+2 Motile Cilium Dynein Axonemal Particle
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Cytoskeletal Motor Activity Protein Binding Dynein Light Chain Binding Dynein Heavy Chain Binding
	Biological Process	Skeletal System Development Neural Plate Development Heart Looping Atrial Cardiac Muscle Tissue Development Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Determination Of Left/right Symmetry Gastrulation Pattern Specification Process Nervous System Development Central Nervous System Development Mesoderm Development Heart Development Embryonic Pattern Specification Anterior/posterior Pattern Specification Gene Expression Stem Cell Population Maintenance Hippocampus Development Olfactory Bulb Development Cell Differentiation Neuron Differentiation Lung Development Germ-line Stem Cell Population Maintenance Forebrain Development Limb Morphogenesis Central Nervous System Segmentation Determination Of Pancreatic Left/right Asymmetry Determination Of Left/right Asymmetry In Nervous System Outer Ear Morphogenesis MRNA Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Axial Mesoderm Development Paraxial Mesoderm Development Stem Cell Differentiation Face Development Left/right Pattern Formation Left/right Axis Specification Determination Of Digestive Tract Left/right Asymmetry Determination Of Liver Left/right Asymmetry Primitive Streak Formation Maintenance Of Cell Number Cranial Skeletal System Development	Cilium Movement Epithelial Cilium Movement Involved In Extracellular Fluid Movement Determination Of Left/right Symmetry Heart Development Insulin Receptor Signaling Pathway Cell Projection Organization Flagellated Sperm Motility Outer Dynein Arm Assembly
Pathways		POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells
Drugs
Diseases		Heterotaxy; Situs ambiguus	Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
GWAS		Refractive error ( 32231278)	Anti-drug antibodies in autoimmune disease (time to event) ( 33125391)
Interacting Genes		9 interacting genes: CTNNB1 DNAI1 GLI3 MESP1 POFUT1 SRF TP53 TWIST1 UBASH3A	8 interacting genes: ATG10 CDKN2A EEF1AKMT3 GLDC NPR2 PAFAH1B1 SQSTM1 ZIC3
Entrez ID		7547	27019
HPRD ID		02225	05080
Ensembl ID		ENSG00000156925	ENSG00000122735
Uniprot IDs		O60481	A0A087WWV9 A0A140VJI0 Q9UI46
PDB IDs		2EJ4 2RPC	8J07
Enriched GO Terms of Interacting Partners?		Heart Development Gastrulation Pattern Specification Process Embryonic Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Regionalization In Utero Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Chordate Embryonic Development Cis-regulatory Region Sequence-specific DNA Binding Stem Cell Differentiation Smooth Muscle Cell Differentiation Histone Deacetylase Binding Developmental Growth Animal Organ Development Tissue Morphogenesis Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Neuroblast Proliferation T Cell Differentiation In Thymus Cardiac Vascular Smooth Muscle Cell Differentiation Neuroblast Proliferation Embryonic Digit Morphogenesis Animal Organ Morphogenesis Formation Of Primary Germ Layer Cell Motility Forebrain Development Positive Regulation Of DNA-templated Transcription Initiation Cranial Suture Morphogenesis Regulation Of MiRNA Transcription Stem Cell Proliferation Embryonic Skeletal System Morphogenesis Embryonic Limb Morphogenesis Regulation Of Stem Cell Proliferation Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Initiation Vascular Associated Smooth Muscle Cell Differentiation Tube Morphogenesis Negative Regulation Of Cell Differentiation Regulation Of MiRNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Neural Precursor Cell Proliferation Thymocyte Apoptotic Process Neural Precursor Cell Proliferation Tissue Development Hematopoietic Or Lymphoid Organ Development Morphogenesis Of An Epithelium	Autophagy Of Mitochondrion DNA-templated Transcription Positive Regulation Of Macrophage Apoptotic Process Nucleobase-containing Compound Biosynthetic Process Intracellular Signal Transduction Negative Regulation Of Protein Ubiquitination Stem Cell Division Protein K63-linked Ubiquitination Autophagy Cell Population Proliferation Ligase Inhibitor Activity Negative Regulation Of Post-translational Protein Modification Apoptotic Process Involved In Mammary Gland Involution Stem Cell Population Maintenance Catabolic Process Glycine Decarboxylation Via Glycine Cleavage System Response To Lipoic Acid Glycine Cleavage Complex Glycine Dehydrogenase (decarboxylating) Activity Pyridoxal Binding Glycine Catabolic Process Response To Methylamine Limb Morphogenesis Cumulus Cell Differentiation Natriuretic Peptide Receptor Activity Vestibulocochlear Nerve Maturation Nerve Maturation C-di-GMP Signaling Granulosa Cell Differentiation Activation Of Meiosis Involved In Egg Activation Neuromuscular Process Gastric Emptying Negative Regulation Of Oocyte Maturation Microtubule Sliding 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Forebrain Development Astral Microtubule Hippocampus Development Microtubule Cytoskeleton Organization Involved In Establishment Of Planar Polarity Central Region Of Growth Cone Neural Plate Development Central Nervous System Segmentation Determination Of Left/right Asymmetry In Nervous System Mitophagy Brown Fat Cell Proliferation Amphisome Atg12 Transferase Activity Atg12 Conjugating Enzyme Activity Maintenance Of Cell Number Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution
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