ZIC3

Description		Zic family zinc finger 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Skeletal System Development Neural Plate Development Heart Looping Atrial Cardiac Muscle Tissue Development Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Determination Of Left/right Symmetry Gastrulation Pattern Specification Process Nervous System Development Central Nervous System Development Mesoderm Development Heart Development Embryonic Pattern Specification Anterior/posterior Pattern Specification Gene Expression Stem Cell Population Maintenance Hippocampus Development Olfactory Bulb Development Cell Differentiation Neuron Differentiation Lung Development Germ-line Stem Cell Population Maintenance Forebrain Development Limb Morphogenesis Central Nervous System Segmentation Determination Of Pancreatic Left/right Asymmetry Determination Of Left/right Asymmetry In Nervous System Outer Ear Morphogenesis MRNA Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Axial Mesoderm Development Paraxial Mesoderm Development Stem Cell Differentiation Face Development Left/right Pattern Formation Left/right Axis Specification Determination Of Digestive Tract Left/right Asymmetry Determination Of Liver Left/right Asymmetry Primitive Streak Formation Maintenance Of Cell Number Cranial Skeletal System Development
Pathways		POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells
Drugs
Diseases		Heterotaxy; Situs ambiguus
GWAS		Refractive error ( 32231278)
Novel Interacting Genes		9 novel interacting genes: CTNNB1 DNAI1 GLI3 MESP1 POFUT1 SRF TP53 TWIST1 UBASH3A
Interacting Genes		9 interacting genes: CTNNB1 DNAI1 GLI3 MESP1 POFUT1 SRF TP53 TWIST1 UBASH3A
Entrez ID		7547
HPRD ID		02225
Ensembl ID		ENSG00000156925
Uniprot IDs		O60481
PDB IDs		2EJ4 2RPC
Enriched GO Terms of Interacting Partners?		Heart Development Gastrulation Pattern Specification Process Embryonic Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Regionalization In Utero Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Chordate Embryonic Development Cis-regulatory Region Sequence-specific DNA Binding Stem Cell Differentiation Smooth Muscle Cell Differentiation Histone Deacetylase Binding Developmental Growth Animal Organ Development Tissue Morphogenesis Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Neuroblast Proliferation T Cell Differentiation In Thymus Cardiac Vascular Smooth Muscle Cell Differentiation Neuroblast Proliferation Embryonic Digit Morphogenesis Animal Organ Morphogenesis Formation Of Primary Germ Layer Cell Motility Forebrain Development Positive Regulation Of DNA-templated Transcription Initiation Cranial Suture Morphogenesis Regulation Of MiRNA Transcription Stem Cell Proliferation Embryonic Skeletal System Morphogenesis Embryonic Limb Morphogenesis Regulation Of Stem Cell Proliferation Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Initiation Vascular Associated Smooth Muscle Cell Differentiation Tube Morphogenesis Negative Regulation Of Cell Differentiation Regulation Of MiRNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Neural Precursor Cell Proliferation Thymocyte Apoptotic Process Neural Precursor Cell Proliferation Tissue Development Hematopoietic Or Lymphoid Organ Development Morphogenesis Of An Epithelium
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