ZIC1 and KRTAP19-5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZIC1	KRTAP19-5
Description		Zic family zinc finger 1	keratin associated protein 19-5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Cytosol Intermediate Filament
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Nervous System Development Central Nervous System Development Brain Development Adult Walking Behavior Regulation Of Smoothened Signaling Pathway Gene Expression Spinal Cord Development Hippocampus Development Olfactory Bulb Development Cell Differentiation Forebrain Development Positive Regulation Of Protein Import Into Nucleus Inner Ear Morphogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Maintenance Of Cell Number
Pathways		Specification of the neural plate border Transcriptional and post-translational regulation of MITF-M expression and activity	Keratinization
Drugs
Diseases
GWAS		Adult body size ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Cortical surface area (MOSTest) ( 32665545) Daytime sleep phenotypes ( 27126917) Monobrow ( 27182965) Multiple sclerosis ( 19010793) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		71 interacting genes: ABHD11 ANKRD10 ARID5A ATP23 BBS4 CDPF1 CFAP68 CRX CYSRT1 DAPL1 EEF1AKMT3 FAM168B FOXH1 GLI1 GLI2 GLI3 INTS11 KLHL26 KRT31 KRT34 KRTAP10-8 KRTAP11-1 KRTAP12-1 KRTAP13-2 KRTAP15-1 KRTAP19-1 KRTAP19-2 KRTAP19-5 KRTAP19-7 KRTAP21-2 KRTAP22-1 KRTAP3-2 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 LITAF MAGED1 METTL27 MGAT5B NFKBID OIP5 OXER1 PATZ1 PEF1 PLAAT1 PLSCR3 RBPMS REL RFC2 RNF144B RUSC1 SMAD4 SMUG1 SPAG8 SPATS1 SUFU TBX19 TEPSIN TLE5 TRAF1 TRIP6 TSC1 UBE2I UFSP1 WWOX YPEL3 ZNF34 ZNF474 ZNF620	97 interacting genes: ANKHD1 APOBEC1 ARID5A ATN1 ATOSB ATPAF2 BHLHE40 C11orf16 CAMK2A CAMK2B CATSPER1 CCDC17 CELF5 CHRD COL8A1 CRACR2A CREB5 CRYAB CYSRT1 DAB1 DAZAP2 DMRT3 DMRTB1 EFEMP2 ENKD1 ESRP1 EVX2 FAM168A GLIS2 GLYCTK GPANK1 GRINA GUCD1 HAPLN2 HGS HOXB9 HYPK INCA1 KIFC3 KPRP KRT34 KRTAP12-4 KRTAP15-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 MAGED1 MAPK1IP1L MGAT5B MYOZ3 MYPOP OIP5 OLIG3 OXER1 P4HA3 PATZ1 PITX1 PITX2 PLSCR4 POU2AF1 PPP1R16A PRKAG3 PRPF31 PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA3 PSMB2 PSMB4 RBPMS RBPMS2 RHOXF2 RNF38 RNF44 RTP5 RUSC1 SAXO4 SEMA3B SNRPC SOHLH1 SPMIP6 SPMIP9 TCF7L2 TEKT3 TLE5 TNIP1 TSPYL6 UBQLN2 VAC14 VEZF1 VPS37C ZBTB32 ZIC1 ZNF414
Entrez ID		7545	337972
HPRD ID		02718	11209
Ensembl ID		ENSG00000152977	ENSG00000186977
Uniprot IDs		Q15915	Q3LI72
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament GLI-SUFU Complex Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Cytosol Keratin Filament Spinal Cord Dorsal/ventral Patterning Protein Binding Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Ciliary Base Ciliary Tip Ventral Midline Development Activin Responsive Factor Complex Morphogenesis Of An Epithelium Hindgut Morphogenesis Dorsal/ventral Pattern Formation Cerebellar Cortex Morphogenesis Proximal/distal Pattern Formation Osteoblast Differentiation Tube Morphogenesis Pituitary Gland Development Tissue Morphogenesis Smoothened Signaling Pathway Negative Regulation Of Wnt Signaling Pathway	Protein Binding Axonemal A Tubule Inner Sheath Identical Protein Binding Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Myoblast Fate Commitment Sperm Flagellum Spinal Cord Motor Neuron Migration Proteasome Core Complex Nucleus Calcium- And Calmodulin-dependent Protein Kinase Complex Chromatin Intermediate Filament
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