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ZAP70 and WIPF1
Number of citations of the paper that reports this interaction (PubMedID
12504004
)
0
Data Source:
HPRD
(in vivo)
ZAP70
WIPF1
Description
zeta chain of T cell receptor associated protein kinase 70
WAS/WASL interacting protein family member 1
Image
GO Annotations
Cellular Component
Immunological Synapse
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Membrane
T Cell Receptor Complex
Membrane Raft
Ruffle
Cytoplasm
Cytosol
Cytoskeleton
Actin Filament
Actin Cytoskeleton
Cytoplasmic Vesicle
Cell Projection
Molecular Function
Nucleotide Binding
Phosphotyrosine Residue Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Actin Binding
Protein Binding
Profilin Binding
Cytoskeletal Anchor Activity
SH3 Domain Binding
Protein Folding Chaperone
Biological Process
Adaptive Immune Response
Immune System Process
Protein Phosphorylation
Immune Response
Leukocyte Cell-cell Adhesion
Peptidyl-tyrosine Phosphorylation
Calcium-mediated Signaling
T Cell Differentiation
Intracellular Signal Transduction
T Cell Activation
B Cell Activation
Beta Selection
Positive Regulation Of MAPK Cascade
Positive Thymic T Cell Selection
Negative Thymic T Cell Selection
Thymic T Cell Selection
Positive Regulation Of T Cell Differentiation
Alpha-beta T Cell Differentiation
Positive Regulation Of Alpha-beta T Cell Differentiation
Positive Regulation Of Alpha-beta T Cell Proliferation
Positive Regulation Of Calcium-mediated Signaling
T Cell Receptor Signaling Pathway
Leukocyte Migration
T Cell Aggregation
T Cell Migration
Protein Folding
Actin Polymerization Or Depolymerization
Actin Filament-based Process
Actin Filament-based Movement
Response To Other Organism
Protein-containing Complex Assembly
Pathways
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
RHOH GTPase cycle
Nuclear events stimulated by ALK signaling in cancer
Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate WASPs and WAVEs
CDC42 GTPase cycle
RAC1 GTPase cycle
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
Drugs
Staurosporine
Fostamatinib
Diseases
Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS
Bipolar disorder (
31043756
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cardiac Troponin-T levels (
31014085
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Diastolic blood pressure (
30224653
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Atrial fibrillation (
29892015
30061737
)
Mean platelet volume (
32888494
)
Platelet distribution width (
32888494
)
Pulse pressure (
27841878
)
Resting heart rate (
27798624
)
Systolic blood pressure (
27841878
)
Urate levels (BMI interaction) (
25811787
)
Interacting Genes
68 interacting genes:
ABL1
ACP1
ANAPC11
APP
ASB3
CARD11
CBL
CBLB
CBLC
CD247
CD3E
CD5
CD79B
CRK
CSK
CUL3
DAPK1
DBNL
DEF6
DUSP3
EGFR
ERBB2
ERBB3
ERBB4
FCGR3A
FCRL3
FYN
GAB2
GRB2
IFNAR1
KIT
LAT
LAX1
LCK
LCP2
LRRK2
MET
MUC1
NDUFB8
NFAM1
NR0B2
PAG1
PELI1
PLCG1
PRLR
PTK2B
PTPN22
PTPN3
PTPN6
PTPRC
RASA1
RNF41
SH2B3
SH3BP2
SHB
SHC1
SIT1
SLA
SLA2
SLAMF6
SOS1
TUBA1A
TUBA4A
TUBB
TYROBP
USP2
VAV1
WIPF1
27 interacting genes:
ABI2
ACTC1
ACTG1
ALAS1
APBB1
CACNG2
CDC42
CEBPA
CRKL
CTTN
FASTK
GRB2
HCK
HLCS
HOMER3
ITSN2
NCK1
PRKCQ
PRPF40A
RER1
SEC24C
SH3RF1
WAS
WASL
WBP4
WWP2
ZAP70
Entrez ID
7535
7456
HPRD ID
01495
03835
Ensembl ID
ENSG00000115085
ENSG00000115935
Uniprot IDs
P43403
A0A140VJZ9
E9PB87
O43516
Q2YDC4
PDB IDs
1FBV
1M61
1U59
2CBL
2OQ1
2OZO
2Y1N
3ZNI
4A4B
4A4C
4K2R
4XZ0
4XZ1
5O76
7SIY
2A41
9EZN
9EZO
9EZP
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Signaling Pathway
Regulation Of Cell Activation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Phosphotyrosine Residue Binding
Antigen Receptor-mediated Signaling Pathway
Signal Transduction
Regulation Of Lymphocyte Activation
Regulation Of Immune System Process
Immune Response-activating Cell Surface Receptor Signaling Pathway
Leukocyte Activation
Positive Regulation Of Immune System Process
Lymphocyte Activation
Cell Activation
Immune Response-regulating Signaling Pathway
Regulation Of Immune Response
Immune Response-activating Signaling Pathway
Immune System Process
Regulation Of T Cell Activation
Regulation Of MAPK Cascade
Regulation Of Intracellular Signal Transduction
T Cell Activation
Intracellular Signal Transduction
Activation Of Immune Response
Plasma Membrane
Positive Regulation Of Immune Response
T Cell Receptor Signaling Pathway
Regulation Of Signal Transduction
Regulation Of Cell Adhesion
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Signaling
Regulation Of Cell Communication
Membrane Raft
Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Cell Activation
Regulation Of Cell-cell Adhesion
Positive Regulation Of Lymphocyte Activation
Regulation Of Multicellular Organismal Process
Enzyme-linked Receptor Protein Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
T Cell Costimulation
Leukocyte Proliferation
Regulation Of T Cell Receptor Signaling Pathway
ERBB Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
SH3 Domain Binding
Negative Regulation Of Cell Adhesion
Fc Receptor Signaling Pathway
Lymphocyte Proliferation
Positive Regulation Of Multicellular Organismal Process
Mononuclear Cell Proliferation
Actin Filament
Regulation Of Actin Filament Organization
Regulation Of Actin Cytoskeleton Organization
Regulation Of Actin Filament-based Process
Regulation Of Supramolecular Fiber Organization
Cell Motility
Positive Regulation Of Supramolecular Fiber Organization
Positive Regulation Of Cytoskeleton Organization
Lamellipodium
Cell-cell Junction
Phosphotyrosine Residue Binding
Positive Regulation Of Actin Filament Polymerization
Regulation Of Cytoskeleton Organization
Actin Filament-based Process
Actin Filament Organization
Proline-rich Region Binding
Regulation Of Actin Polymerization Or Depolymerization
Regulation Of Actin Filament Length
Cell Projection Morphogenesis
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Cell Migration
Cytosol
Regulation Of Cell Projection Organization
Positive Regulation Of Protein Polymerization
Positive Regulation Of Organelle Organization
Positive Regulation Of Cellular Component Biogenesis
Actin Cytoskeleton Organization
Dendritic Spine Organization
Cell Projection Organization
Regulation Of Cell Projection Assembly
Regulation Of Lamellipodium Assembly
Vesicle Membrane
Regulation Of Cellular Component Organization
Positive Regulation Of Cellular Component Organization
Intracellular Signaling Cassette
Immune Response-regulating Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Neuron Projection Organization
Regulation Of Cellular Component Size
Regulation Of Actin Filament Polymerization
Postsynapse Organization
Neuron Projection Morphogenesis
Regulation Of Organelle Organization
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Small GTPase-mediated Signal Transduction
Cell Junction Organization
Peptidyl-tyrosine Phosphorylation
Regulation Of Lamellipodium Organization
Regulation Of Immune System Process
Antigen Receptor-mediated Signaling Pathway
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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