YWHAH and CDK16

Number of citations of the paper that reports this interaction (PubMedID 36931259)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		YWHAH	CDK16
Description		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta	cyclin dependent kinase 16
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Plasma Membrane Intercalated Disc Synapse Extracellular Exosome Presynapse Glutamatergic Synapse Cerebellar Granule Cell To Purkinje Cell Synapse	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Cytoplasm Cytosol Plasma Membrane Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Microtubule Cytoskeleton Membrane Transport Vesicle Cytoplasmic Vesicle Neuron Projection Synapse
	Molecular Function	Actin Binding Insulin-like Growth Factor Receptor Binding Protein Binding Sodium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding Nuclear Glucocorticoid Receptor Binding Identical Protein Binding Transmembrane Transporter Binding Protein Heterodimerization Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Regulation Of Sodium Ion Transport Glucocorticoid Catabolic Process Intracellular Protein Transport Signal Transduction Intracellular Protein Localization Substantia Nigra Development Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Membrane Depolarization During Action Potential Presynaptic Modulation Of Chemical Synaptic Transmission	Protein Phosphorylation Exocytosis Spermatogenesis Positive Regulation Of Autophagy Cell Differentiation Growth Hormone Secretion Neuron Projection Development Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Cell Cycle Phase Transition
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs		Phenethyl Isothiocyanate	(2Z,3E)-2,3'-biindole-2',3(1H,1'H)-dione 3-{O-[(3R)-3,4-dihydroxybutyl]oxime} Fostamatinib
Diseases
GWAS		Post bronchodilator FEV1 ( 26634245) Type 2 diabetes ( 30297969)
Interacting Genes		69 interacting genes: ABL1 ARHGEF28 BAD BCR BRAF CCDC125 CDC25B CDC25C CDC42 CDK16 CDKN1B CHRNA4 CREBBP EPB41L2 EPB41L3 ESR1 ESR2 EXO1 GREM1 HSPB1 ILF3 ING1 KANK1 KCNH2 KCNK15 KCNK3 KCNK9 KLC3 KRT18 MAP3K3 MAP3K5 MARK4 MDM4 MED1 MST1R NCAM2 NCOA1 NCOA2 NCOA3 NEDD4L NEK1 NHSL2 NR3C1 NRIP1 PARD3 PARD6A PARD6B PCNT PDPK1 PRKCI PRKN PTH1R RAF1 REM1 RIMS1 RIMS2 RPH3A SAMSN1 SNCA SRC THRA TLX2 TNFAIP3 TPH1 TSC1 TSC2 YWHAE YWHAG ZFP36	20 interacting genes: APP APPBP2 ATRIP BAG6 CCND3 CDK5 CDK5R1 MAGI3 PJA1 PRKACA S100A10 SEC23A SIRPA SNX27 YWHAE YWHAG YWHAH YWHAQ YWHAZ ZBTB14
Entrez ID		7533	5127
HPRD ID		00215	02409
Ensembl ID		ENSG00000128245	ENSG00000102225
Uniprot IDs		Q04917 Q9H4N8	A0A140VK97 Q00536 Q9BRL4
PDB IDs		2C63 2C74 7NMZ	3MTL 5G6V
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Nuclear Receptor-mediated Signaling Pathway Cytosol Regulation Of Cell Communication Regulation Of Signaling Regulation Of Programmed Cell Death Regulation Of Signal Transduction Intracellular Receptor Signaling Pathway Regulation Of Developmental Process Regulation Of Biological Quality PAR Polarity Complex Regulation Of Intracellular Signal Transduction Regulation Of Transport Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Phosphorylation Regulation Of Membrane Potential Regulation Of Apoptotic Process Regulation Of Vesicle-mediated Transport Cell Junction Organization Negative Regulation Of Apoptotic Process Phosphorylation Positive Regulation Of Metabolic Process Enzyme Binding Negative Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Response To Lipid Cellular Response To Hormone Stimulus Hormone-mediated Signaling Pathway Positive Regulation Of Transport Positive Regulation Of Developmental Process Positive Regulation Of Protein Localization Protein Kinase Binding Regulation Of Anatomical Structure Morphogenesis Developmental Process Cytoskeleton Organization Cellular Response To Lipid Positive Regulation Of Intracellular Signal Transduction Regulation Of Secretion By Cell Regulation Of Phosphorus Metabolic Process Regulation Of Protein Localization Positive Regulation Of Biosynthetic Process Protein Serine/threonine Kinase Activity Synaptic Vesicle Priming Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Protein Kinase Activity	Establishment Of Protein Localization Protein Domain Specific Binding Transmembrane Transporter Binding Acetylcholine Receptor Activator Activity Intracellular Protein Localization Cellular Localization Protein Targeting Protein Kinase 5 Complex Intracellular Signal Transduction Regulation Of Protein Export From Nucleus Regulation Of Synapse Organization Neuron Recognition Cyclin-dependent Protein Kinase Holoenzyme Complex Protein Sequestering Activity Phosphoserine Residue Binding Substantia Nigra Development Localization Within Membrane Establishment Of Localization In Cell Intracellular Protein Transport Positive Regulation Of Establishment Of Protein Localization Intracellular Transport Negative Regulation Of Macromolecule Metabolic Process Extracellular Exosome Regulation Of Protein Localization Protein Catabolic Process TORC1 Signaling Neural Nucleus Development Regulation Of Proteolysis Regulation Of Neuron Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Cytoplasm Negative Regulation Of TORC1 Signaling Positive Regulation Of Neuron Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Hippocampus Development Regulation Of Synaptic Plasticity Negative Regulation Of Biosynthetic Process Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Regulation Of Monoatomic Ion Transport Neuromuscular Junction Macromolecule Catabolic Process TOR Signaling Presynapse Regulation Of Developmental Process Negative Regulation Of TOR Signaling Insulin-like Growth Factor Receptor Binding Signal Transduction Proteasomal Protein Catabolic Process Protein Phosphatase Binding
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