XBP1 and H1-0

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		XBP1	H1-0
Description		X-box binding protein 1	H1.0 linker histone
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleosome Euchromatin Nucleus Nucleoplasm Chromosome Golgi Apparatus Actin Cytoskeleton Nuclear Body Transcription Repressor Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Protease Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Nuclear Estrogen Receptor Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding Ubiquitin-like Protein Ligase Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding	DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosome Binding Nucleosomal DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Regulation Of Cell Growth Liver Development Positive Regulation Of Protein Phosphorylation Endothelial Cell Proliferation Glandular Epithelial Cell Maturation Positive Regulation Of Immunoglobulin Production Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Lipid Metabolic Process Fatty Acid Biosynthetic Process Autophagy Apoptotic Process Immune Response Response To Unfolded Protein Muscle Organ Development Positive Regulation Of Cell Population Proliferation Regulation Of Autophagy Positive Regulation Of Autophagy Negative Regulation Of Myotube Differentiation Protein Transport Cell Differentiation Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Exocrine Pancreas Development Regulation Of Protein Stability Protein Destabilization Cellular Response To Nutrient Positive Regulation Of TOR Signaling Positive Regulation Of Interleukin-6 Production Cellular Response To Insulin Stimulus Cellular Response To Oxidative Stress Response To Endoplasmic Reticulum Stress Intracellular Triglyceride Homeostasis Positive Regulation Of Vascular Wound Healing Cellular Response To Vascular Endothelial Growth Factor Stimulus IRE1-mediated Unfolded Protein Response ATF6-mediated Unfolded Protein Response ERAD Pathway Cellular Response To Glucose Starvation Positive Regulation Of Protein Import Into Nucleus Cholesterol Homeostasis Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Vascular Endothelial Growth Factor Receptor Signaling Pathway Neuron Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Fatty Acid Homeostasis Sterol Homeostasis Negative Regulation Of SMAD Protein Signal Transduction Adipose Tissue Development Epithelial Cell Maturation Involved In Salivary Gland Development Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Phospholipid Biosynthetic Process Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Fructose Stimulus Cellular Response To Glucose Stimulus Cellular Response To Interleukin-4 Cellular Response To Peptide Hormone Stimulus Cellular Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Positive Regulation Of Plasma Cell Differentiation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Acetylation Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Lactation Positive Regulation Of ERAD Pathway Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Response To Insulin-like Growth Factor Stimulus Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Endothelial Cell Apoptotic Process	Nucleosome Assembly Chromosome Condensation Heterochromatin Formation Negative Regulation Of DNA Recombination Positive Regulation Of Transcription Regulatory Region DNA Binding
Pathways			Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS		Esophageal cancer (squamous cell) ( 22960999) Esophageal squamous cell carcinoma ( 25129146) Heel bone mineral density ( 28869591) Mean arterial pressure ( 29403010) Pancreatic cancer ( 25086665) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		22 interacting genes: ATF6 ATF6B CREBZF ESR1 FOS FUBP3 GLI1 H1-0 H1-10 HDGF MDM2 MTNR1B NR0B2 PCBD2 RBL2 SRSF1 SSX4 TRIP4 UBE2I UBE2V1 ZNF440 ZNF580	20 interacting genes: APP CCNE1 CDK1 CDK2 CDK4 CDK5 FBXO7 GRB2 HPF1 IKBKG IPO5 IPO7 KPNA2 KPNB1 NEDD4L NOA1 PARP2 PRKCB RAD51B XBP1
Entrez ID		7494	3005
HPRD ID		01908	00819
Ensembl ID		ENSG00000100219	ENSG00000189060
Uniprot IDs		B1AHH1 P17861	P07305
PDB IDs		6R5Q 6R6G 6R6P 6R7Q	6HQ1 6LA2 6LA8 6LA9 6LAB 6N88 6N89 7COW 7DBP 7K5X 7XVL 7XX6 8TB9 9IPU
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process ATF6-mediated Unfolded Protein Response Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleus DNA Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Chromatin Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Transcription By RNA Polymerase II ER-nucleus Signaling Pathway DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Coregulator Binding RNA Polymerase II Transcription Regulator Complex Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Animal Organ Regeneration Negative Regulation Of Nucleobase-containing Compound Metabolic Process Peroxisome Proliferator Activated Receptor Binding Transcription Repressor Complex Endoplasmic Reticulum Unfolded Protein Response RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cellular Response To Estrogen Stimulus SUMO Transferase Activity Transcription Cis-regulatory Region Binding Cellular Response To Reactive Oxygen Species Estrogen Receptor Signaling Pathway Response To Immobilization Stress Chromatin Organization Negative Regulation Of Macromolecule Metabolic Process Liver Regeneration Regeneration Sequence-specific Double-stranded DNA Binding Regulation Of Endoplasmic Reticulum Unfolded Protein Response Nuclear Estrogen Receptor Binding	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleoplasm Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Positive Regulation Of Mitotic Cell Cycle Regulation Of Protein Localization Regulation Of Cell Cycle Phase Transition Regulation Of Protein Localization To Nucleus Cytosol Regulation Of Mitotic Cell Cycle Acetylcholine Receptor Activator Activity Positive Regulation Of Establishment Of Protein Localization Nucleus Nuclear Import Signal Receptor Activity Regulation Of Mitotic Cell Cycle Phase Transition Nuclear Localization Sequence Binding G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Cell Cycle G1/S Phase Transition NLS-bearing Protein Import Into Nucleus Apoptotic Process Cyclin E1-CDK2 Complex Cyclin-dependent Protein Kinase Activity Positive Regulation Of Mitotic Cell Cycle Phase Transition Protein Localization To Organelle Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Localization To Nucleus Programmed Cell Death Cell Death Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Protein Transport Positive Regulation Of Protein Localization Positive Regulation Of Protein Transport Cyclin Binding Ribosomal Protein Import Into Nucleus Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Cycle Phase Transition Regulation Of Nucleocytoplasmic Transport Intracellular Protein Localization Regulation Of Cell Cycle G2/M Phase Transition Protein Import Into Nucleus DNA Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Protein Import Into Nucleus Import Into Nucleus DNA Damage Response Histone Kinase Activity Regulation Of Establishment Of Protein Localization Regulation Of Intracellular Protein Transport
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