TMEM258 and FADS2

		TMEM258	FADS2
Description		transmembrane protein 258	fatty acid desaturase 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Oligosaccharyltransferase Complex Membrane Oligosaccharyltransferase Complex A Oligosaccharyltransferase Complex B	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	Protein Binding Oligosaccharyltransferase Complex Binding	Stearoyl-CoA 9-desaturase Activity Protein Binding Acyl-CoA 6-desaturase Activity Acyl-CoA Desaturase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Oxidation Of A Pair Of Donors Resulting In The Reduction Of Molecular Oxygen To Two Molecules Of Water
	Biological Process	Protein Glycosylation Protein N-linked Glycosylation Inflammatory Response Response To Endoplasmic Reticulum Stress Epithelial Cell Apoptotic Process	Arachidonate Metabolite Production Involved In Inflammatory Response Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Linoleic Acid Metabolic Process Positive Regulation Of Cellular Response To Oxidative Stress Fatty Acid Derivative Biosynthetic Process
Pathways		Asparagine N-linked glycosylation Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane PD-L1(CD274) glycosylation and translocation to plasma membrane	Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism alpha-linolenic acid (ALA) metabolism
Drugs			alpha-Linolenic acid
Diseases
GWAS		Asthma ( 31959851 31619474) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 28067908) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil count ( 32888494) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Male-pattern baldness ( 28196072) QRS duration ( 27659466) Red blood cell count ( 32888494 27863252) Refractive error ( 32231278) Resting heart rate ( 27798624) Reticulocyte count ( 32888494) Serum metabolite concentrations in chronic kidney disease ( 33838163 29545352) Serum metabolite levels ( 31636271 33031748) Serum metabolite levels (CMS) ( 31636271) Serum metabolite ratios in chronic kidney disease ( 29545352)	Alanine aminotransferase levels ( 33339817) Albumin-globulin ratio ( 29403010) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Aortic valve stenosis ( 32186652) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Asthma ( 31619474 31959851 32296059) Asthma (adult onset) ( 31036433) Bipolar disorder ( 28115744 31043756 34002096) Bipolar I disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Change in serum metabolite levels ( 31636271) Change in serum metabolite levels (CMS) ( 31636271) Cholesterol, total ( 19060911 20686565 24097068 25961943) Cholesteryl ester levels ( 31551469) Colorectal cancer ( 24836286) Comprehensive strength and appendicular lean mass ( 22960237) Crohn's disease ( 28067908) Daytime nap ( 33568662) Delta-5 desaturase activity response to n3-polyunsaturated fat supplement ( 29246731) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil percentage of white cells ( 32888494) Fasting glucose ( 34059833) Fatty acid desaturase activity (serum) ( 30453627) Gallstone disease ( 30504769) Glycated hemoglobin levels ( 24647736 28898252) Gondoic acid (20:1n-9) levels ( 28298293) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 19060906 19060911 20686565 24097068 25961943) HDL cholesterol levels ( 28334899 30698716 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 28869591) Height ( 31562340) Hematocrit ( 32888494) Hemoglobin A1c levels ( 29403010) Hemoglobin levels ( 32327693) High density lipoprotein cholesterol levels ( 33339817) IgA levels ( 28628107) Inflammatory bowel disease ( 23128233) Iron status biomarkers (transferrin levels) ( 25352340) Laryngeal squamous cell carcinoma ( 25194280) LDL cholesterol ( 19060910 19060911 20686565 24097068 25961943) LDL cholesterol levels ( 28334899 30698716 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 22286219) Liver enzyme levels (alkaline phosphatase) ( 22001757) Low density lipoprotein cholesterol levels ( 32154731 33339817) Lung cancer in ever smokers ( 28604730) Lymphocyte percentage of white cells ( 32888494) Lysophosphatidylcholine levels ( 31551469) Lysophosphatidylethanolamine levels ( 31551469) Male-pattern baldness ( 28196072) Mean platelet volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (thyroid preparations) ( 31015401) Metabolic syndrome ( 20694148 31589552) Metabolite levels ( 22916037 23378610 23823483) Metabolite risk score for predicting weight gain ( 31560688) Monocyte percentage of white cells ( 32888494) Moyamoya disease ( 29273593) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Oleic acid (18:1n-9) levels ( 23362303 28298293) P wave duration ( 24850809) Palmitoleic acid (16:1n-7) levels ( 23362303 28298293) Phosphatidylcholine levels ( 31551469) Phosphatidylcholine-ether levels ( 31551469) Phosphatidylethanolamine levels ( 31551469) Phosphatidylethanolamine-ether levels ( 31551469) Phosphatidylinositol levels ( 31551469) Phospholipid levels (plasma) ( 22359512) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Platelet count ( 29403010 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) PR interval ( 32439900) Pulse pressure ( 30578418) QRS duration ( 27659466) QT interval ( 24952745 29874175) Red blood cell fatty acid levels ( 25500335) Red cell distribution width ( 27863252 32888494) Refractive error ( 32231278) Response to statin therapy ( 20339536) Resting heart rate ( 27798624 29769521) Rheumatoid arthritis ( 24390342 30423114) Serum alkaline phosphatase levels ( 33547301) Serum metabolite concentrations in chronic kidney disease ( 29545352 33838163) Serum metabolite levels ( 23093944 31636271 33031748) Serum metabolite levels (CMS) ( 31636271) Serum metabolite ratios in chronic kidney disease ( 29545352) Serum omega-3 polyunsaturated fatty acid concentration in metabolic syndrome ( 31991592) Sphingolipid levels ( 22359512) Sphingomyelin levels ( 31551469) Stearic acid (18:0) levels ( 23362303) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Total cholesterol levels ( 28334899 29403010 33339817) Triacylglyceride levels ( 31551469) Triacylglycerol 56:6 levels ( 31560688) Triglyceride levels ( 28334899 30698716 32154731 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 19060906 20686565 24097068 25961943) Type 1 diabetes ( 34127860) Urate levels ( 31578528) Vaccenic acid (18:1n-7) levels ( 28298293) Vitiligo ( 27723757)
Interacting Genes		4 interacting genes: ARL6IP1 IER3IP1 MFSD6 UBQLN1	7 interacting genes: ATXN1L GRSF1 KRT31 KRT40 NBPF19 NOTCH2NLA ZNF655
Entrez ID		746	9415
HPRD ID		12602	05854
Ensembl ID		ENSG00000134825	ENSG00000134824
Uniprot IDs		P61165	O95864
PDB IDs		6S7O 6S7T 8B6L 8PN9
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Response To Oxidative Stress Positive Regulation Of Response To Oxidative Stress Acyl-CoA 6-desaturase Activity Endoplasmic Reticulum Acyl-CoA Desaturase Activity Stearoyl-CoA 9-desaturase Activity Endoplasmic Reticulum Organization Negative Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Extracellular Matrix Constituent Secretion Arachidonate Metabolite Production Involved In Inflammatory Response Positive Regulation Of L-glutamate Import Across Plasma Membrane Oxidoreductase Activity, Acting On Paired Donors, With Oxidation Of A Pair Of Donors Resulting In The Reduction Of Molecular Oxygen To Two Molecules Of Water Sec61 Translocon Complex Regulation Of Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Formation Endoplasmic Reticulum Membrane Endoplasmic Reticulum Tubular Network Membrane Organization Regulation Of Extracellular Matrix Constituent Secretion Regulation Of L-glutamate Import Across Plasma Membrane Type B Pancreatic Cell Differentiation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Cellular Response To Oxidative Stress Production Of Molecular Mediator Involved In Inflammatory Response Alpha-linolenic Acid Metabolic Process Linoleic Acid Metabolic Process Endoplasmic Reticulum Membrane Organization Regulation Of Programmed Cell Death Endoplasmic Reticulum Tubular Network Organization Regulation Of Apoptotic Process Cotranslational Protein Targeting To Membrane Aggrephagy Positive Regulation Of ERAD Pathway Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Fibroblast Apoptotic Process Insulin Metabolic Process Enteroendocrine Cell Differentiation Endoplasmic Reticulum Tubular Network Positive Regulation Of Amino Acid Transport Regulation Of Transport Regulation Of ERAD Pathway Negative Regulation Of Transporter Activity Positive Regulation Of Extracellular Matrix Organization
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