TMEM258

Description		transmembrane protein 258
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Oligosaccharyltransferase Complex Membrane Oligosaccharyltransferase Complex A Oligosaccharyltransferase Complex B
	Molecular Function	Protein Binding Oligosaccharyltransferase Complex Binding
	Biological Process	Protein Glycosylation Protein N-linked Glycosylation Inflammatory Response Response To Endoplasmic Reticulum Stress Epithelial Cell Apoptotic Process
Pathways		Asparagine N-linked glycosylation Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane PD-L1(CD274) glycosylation and translocation to plasma membrane
Drugs
Diseases
GWAS		Asthma ( 31959851 31619474) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 28067908) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil count ( 32888494) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Male-pattern baldness ( 28196072) QRS duration ( 27659466) Red blood cell count ( 32888494 27863252) Refractive error ( 32231278) Resting heart rate ( 27798624) Reticulocyte count ( 32888494) Serum metabolite concentrations in chronic kidney disease ( 33838163 29545352) Serum metabolite levels ( 31636271 33031748) Serum metabolite levels (CMS) ( 31636271) Serum metabolite ratios in chronic kidney disease ( 29545352)
Novel Interacting Genes		5 novel interacting genes: ARL6IP1 FADS2 IER3IP1 MFSD6 UBQLN1
Interacting Genes		5 interacting genes: ARL6IP1 FADS2 IER3IP1 MFSD6 UBQLN1
Entrez ID		746
HPRD ID		12602
Ensembl ID		ENSG00000134825
Uniprot IDs		P61165
PDB IDs		6S7O 6S7T 8B6L 8PN9
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Response To Oxidative Stress Positive Regulation Of Response To Oxidative Stress Acyl-CoA 6-desaturase Activity Endoplasmic Reticulum Acyl-CoA Desaturase Activity Stearoyl-CoA 9-desaturase Activity Endoplasmic Reticulum Organization Negative Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Extracellular Matrix Constituent Secretion Arachidonate Metabolite Production Involved In Inflammatory Response Positive Regulation Of L-glutamate Import Across Plasma Membrane Oxidoreductase Activity, Acting On Paired Donors, With Oxidation Of A Pair Of Donors Resulting In The Reduction Of Molecular Oxygen To Two Molecules Of Water Sec61 Translocon Complex Regulation Of Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Formation Endoplasmic Reticulum Membrane Endoplasmic Reticulum Tubular Network Membrane Organization Regulation Of Extracellular Matrix Constituent Secretion Regulation Of L-glutamate Import Across Plasma Membrane Type B Pancreatic Cell Differentiation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Cellular Response To Oxidative Stress Production Of Molecular Mediator Involved In Inflammatory Response Alpha-linolenic Acid Metabolic Process Linoleic Acid Metabolic Process Endoplasmic Reticulum Membrane Organization Regulation Of Programmed Cell Death Endoplasmic Reticulum Tubular Network Organization Regulation Of Apoptotic Process Cotranslational Protein Targeting To Membrane Aggrephagy Positive Regulation Of ERAD Pathway Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Fibroblast Apoptotic Process Insulin Metabolic Process Enteroendocrine Cell Differentiation Endoplasmic Reticulum Tubular Network Positive Regulation Of Amino Acid Transport Regulation Of Transport Regulation Of ERAD Pathway Negative Regulation Of Transporter Activity Positive Regulation Of Extracellular Matrix Organization
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