EZR and ROCK1

Number of citations of the paper that reports this interaction (PubMedID 10970850)
53

Data Source:
HPRD (in vivo)

		EZR	ROCK1
Description		ezrin	Rho associated coiled-coil containing protein kinase 1
Image
GO Annotations	Cellular Component	Fibrillar Center Ruffle Immunological Synapse Uropod Extracellular Space Cytoplasm Endosome Cytosol Cytoskeleton Actin Filament Plasma Membrane Microvillus Brush Border Adherens Junction Focal Adhesion Cell Cortex Actin Cytoskeleton Membrane Basolateral Plasma Membrane Apical Plasma Membrane Filopodium Cortical Cytoskeleton Microvillus Membrane Vesicle Ruffle Membrane Protein-containing Complex Ciliary Basal Body Cell Projection Plasma Membrane Raft Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery	Golgi Membrane Ruffle Extracellular Region Cytoplasm Golgi Apparatus Centriole Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Stress Granule Membrane Lamellipodium Bleb Secretory Granule Lumen Cell Projection Schaffer Collateral - CA1 Synapse
	Molecular Function	RNA Binding Actin Binding Protein Binding Microtubule Binding Cytoskeletal Protein Binding Protein Domain Specific Binding Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Identical Protein Binding S100 Protein Binding Cadherin Binding Cell Adhesion Molecule Binding Actin Filament Binding Protein Kinase A Binding ATPase Binding Disordered Domain Specific Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Small GTPase Binding Metal Ion Binding Tau Protein Binding Tau-protein Kinase Activity Rho-dependent Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Intestinal D-glucose Absorption Sphingosine-1-phosphate Receptor Signaling Pathway Leukocyte Cell-cell Adhesion Regulation Of Cell Shape Positive Regulation Of Gene Expression Protein Kinase A Signaling Gland Morphogenesis Membrane To Membrane Docking Microvillus Assembly Actin Cytoskeleton Organization Astral Microtubule Organization Protein-containing Complex Localization Receptor Internalization Regulation Of Microvillus Length Negative Regulation Of Interleukin-2 Production Regulation Of Actin Cytoskeleton Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Multicellular Organism Growth Cortical Microtubule Organization Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Protein Catabolic Process Filopodium Assembly Negative Regulation Of T Cell Receptor Signaling Pathway Actin Filament Bundle Assembly Establishment Of Centrosome Localization Establishment Of Endothelial Barrier Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Protein Localization To Plasma Membrane Protein Localization To Cell Cortex Postsynaptic Actin Cytoskeleton Organization Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Organelle Assembly Terminal Web Assembly Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of P38MAPK Cascade Positive Regulation Of Early Endosome To Late Endosome Transport	Mitotic Cytokinesis Epithelial To Mesenchymal Transition Aortic Valve Morphogenesis Apical Constriction Apoptotic Process Smooth Muscle Contraction Leukocyte Cell-cell Adhesion Signal Transduction Rho Protein Signal Transduction Regulation Of Gene Expression Positive Regulation Of Autophagy Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Angiogenesis Peptidyl-serine Phosphorylation Membrane To Membrane Docking Actin Cytoskeleton Organization Regulation Of Cell Adhesion Regulation Of Cell Migration Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization Neuron Projection Development Bleb Assembly Negative Regulation Of Protein Binding Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Keratinocyte Differentiation Regulation Of Neuron Differentiation Positive Regulation Of Phosphate Metabolic Process Embryonic Morphogenesis Leukocyte Migration Leukocyte Tethering Or Rolling Negative Regulation Of Membrane Protein Ectodomain Proteolysis Myoblast Migration Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Positive Regulation Of Focal Adhesion Assembly MRNA Destabilization Negative Regulation Of Biomineral Tissue Development Regulation Of Microtubule Cytoskeleton Organization Response To Transforming Growth Factor Beta Protein Localization To Plasma Membrane Regulation Of Synapse Maturation Podocyte Cell Migration Motor Neuron Apoptotic Process Blood Vessel Diameter Maintenance Regulation Of Angiotensin-activated Signaling Pathway Neuron Projection Arborization Positive Regulation Of Amyloid-beta Clearance Regulation Of Synaptic Vesicle Endocytosis Regulation Of Cell Junction Assembly Regulation Of Amyloid-beta Formation Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Connective Tissue Replacement Response To Angiotensin Regulation Of Establishment Of Cell Polarity Regulation Of Cell Motility Negative Regulation Of Motor Neuron Apoptotic Process
Pathways		Netrin-1 signaling Recycling pathway of L1 Recycling pathway of L1 Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Apoptotic cleavage of cellular proteins EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse VEGFA-VEGFR2 Pathway RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs Neutrophil degranulation RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RHOH GTPase cycle RHOBTB1 GTPase cycle Potential therapeutics for SARS RND3 GTPase cycle
Drugs			Hydroxyfasudil (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE Fasudil Y-27632 Ripasudil Netarsudil Belumosudil
Diseases
GWAS		Bladder cancer (smoking interaction) ( 24662972) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Hair color ( 29662168) Refractive error ( 32231278)	Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Lysophosphatidylcholine levels ( 31551469) Telomere length ( 30185882)
Interacting Genes		57 interacting genes: ACTB ACTC1 ADORA2B ADRA1B ARF6 ARHGDIB CD44 CDH1 CDK5 CEBPA CFTR CLIC5 CTNNB1 DLG1 EGFR ERBB3 FAS FASLG GZMM ICAM1 ICAM2 ICAM3 IQGAP1 L1CAM LCK MDM2 MME MPP3 MSN NF2 NHERF1 NHERF2 PALLD PIK3R1 PRKAR2A PRKCA PTK2 PTPRC RDX ROCK1 RSPH1 S100P SCYL3 SDC2 SELL SELP SLC26A4-AS1 SPN SUMO2 TBC1D10A TMEM8B TSC1 USP1 VCAM1 VPS11 WFDC1 WWOX	40 interacting genes: ADD1 ARHGAP24 CASP3 CASP7 CDC25A CDC34 CFAP206 CRMP1 DES DPYSL2 EZR FAM124A GFAP HMGB2 IKBKB IRS1 ITSN2 LIMK1 LIMK2 LINC00452 LMO2 MAGEB4 MLC1 MSN PFN2 POLR3C PPP1R12A PTK2 RDX RHOA RHOB RHOC RND3 SMAD2 SMAD5 TPPP TRIM15 TSG101 UBE2T VIM
Entrez ID		7430	6093
HPRD ID		00475	03414
Ensembl ID		ENSG00000092820	ENSG00000067900
Uniprot IDs		P15311	Q13464
PDB IDs		1NI2 4RM8 4RM9 4RMA 7T1K 7T1L	1S1C 2ESM 2ETK 2ETR 2V55 3D9V 3NCZ 3NDM 3O0Z 3TV7 3TWJ 3V8S 4L2W 4W7P 4YVC 4YVE 5BML 5F5P 5HVU 5KKS 5KKT 5UZJ 5WNE 5WNF 5WNG 5WNH 6E9W 7JOU 7S25 7S26 8P0S 8ZH5
Enriched GO Terms of Interacting Partners?		Plasma Membrane Cell Adhesion Cell-cell Adhesion Focal Adhesion Leukocyte Cell-cell Adhesion Cell Migration Cell Motility Microvillus Regulation Of Intracellular Signal Transduction Lamellipodium Extracellular Exosome Membrane Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Adhesion Membrane To Membrane Docking Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Leukocyte Tethering Or Rolling Regulation Of Multicellular Organismal Process Response To Growth Factor Positive Regulation Of Transport Regulation Of Cell-cell Adhesion Filopodium Regulation Of Developmental Process Regulation Of Cell Migration Cell Projection Regulation Of Signal Transduction Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Cellular Localization Regulation Of Apoptotic Process Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Membrane Docking Cell Surface Cellular Developmental Process Regulation Of Vesicle-mediated Transport Regulation Of Cell Motility Regulation Of Programmed Cell Death Apical Plasma Membrane Integrin Binding Developmental Process Regulation Of Locomotion Cell-substrate Adhesion T Cell Activation Cell-matrix Adhesion Ruffle	Focal Adhesion Cytoskeleton Supramolecular Fiber Organization Regulation Of Cellular Component Organization Cytoskeleton Organization Regulation Of Cytoskeleton Organization Cytoplasm Cytosol Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Localization To Early Endosome Regulation Of Organelle Organization Astral Microtubule Organization Regulation Of Actin Filament-based Process Actin Filament Organization Positive Regulation Of Protein Localization To Endosome Negative Regulation Of Cell Projection Organization Regulation Of Protein-containing Complex Assembly Skeletal Muscle Satellite Cell Migration Positive Regulation Of Stress Fiber Assembly Cleavage Furrow Establishment Of Epithelial Cell Apical/basal Polarity Protein Kinase Binding Regulation Of Establishment Of Endothelial Barrier Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Actin Filament Bundle Assembly Actin Filament Bundle Assembly Cytoplasmic Microtubule Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Actin Filament Bundle Organization Actin Cytoskeleton Organization Developmental Process Establishment Of Apical/basal Cell Polarity Regulation Of Cell Projection Organization Intracellular Signaling Cassette Polarized Epithelial Cell Differentiation Cytoskeletal Protein Binding Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Cellular Component Size Regulation Of Organelle Assembly Negative Regulation Of Cellular Component Organization Regulation Of Actin Filament Organization Cellular Developmental Process Cellular Response To Staurosporine Cell Differentiation Actin Filament-based Process Wound Healing, Spreading Of Cells Establishment Of Epithelial Cell Polarity Regulation Of Adherens Junction Organization
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