VEGFB and UCP2

		VEGFB	UCP2
Description		vascular endothelial growth factor B	uncoupling protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane Platelet Alpha Granule Lumen	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane
	Molecular Function	Vascular Endothelial Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity Identical Protein Binding Vascular Endothelial Growth Factor Receptor 1 Binding Receptor Ligand Activity	Protein Binding Secondary Active Sulfate Transmembrane Transporter Activity Proton Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Oxaloacetate Transmembrane Transporter Activity Malate Transmembrane Transporter Activity L-aspartate Transmembrane Transporter Activity Antiporter Activity Oxidative Phosphorylation Uncoupler Activity GDP Binding Protein Homodimerization Activity Phosphate Ion Uniporter Activity
	Biological Process	Response To Hypoxia Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Protein O-linked Glycosylation Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Vascular Wound Healing Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Vascular Permeability Negative Regulation Of Neuron Apoptotic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cardiac Muscle Contraction Positive Regulation Of Mast Cell Chemotaxis Coronary Vasculature Development Positive Regulation Of ERK1 And ERK2 Cascade	Mitochondrial Fission Response To Superoxide Response To Hypoxia Glycolytic Process Glutamine Metabolic Process Mitochondrial Transport Response To Cold Response To Glucose Inorganic Anion Transport C4-dicarboxylate Transport Long-chain Fatty Acid Transport Macrophage Differentiation Cellular Response To Insulin Stimulus Cellular Response To Hormone Stimulus Cellular Response To Amino Acid Starvation Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Regulation Of Mitochondrial Membrane Potential Transmembrane Transport Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Fatty Acid L-aspartate Transmembrane Transport Cellular Response To Lead Ion Cellular Response To Glucose Stimulus Malate Transmembrane Transport Response To Dexamethasone Reactive Oxygen Species Metabolic Process Liver Regeneration Negative Regulation Of Calcium Import Into The Mitochondrion Positive Regulation Of Cold-induced Thermogenesis Oxaloacetate(2-) Transmembrane Transport Sulfate Transmembrane Transport Chloride Transmembrane Transport Proton Transmembrane Transport Mitochondrial Transmembrane Transport Adaptive Thermogenesis
Pathways		Platelet degranulation VEGF ligand-receptor interactions VEGF binds to VEGFR leading to receptor dimerization	The fatty acid cycling model
Drugs		Aflibercept
Diseases		Gastric cancer
GWAS		A body shape index ( 34021172) Apolipoprotein A1 levels ( 32203549) Crohn's disease ( 28067908) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Fruit consumption ( 32066663) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Red blood cell count ( 32888494) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412)	Mean platelet volume ( 32888494)
Interacting Genes		11 interacting genes: ADRB2 FLT1 FOSL1 KLHL12 NRP1 SF1 TFB1M TNXB UCP2 UCP3 VEGFA	7 interacting genes: KRTAP10-3 KRTAP10-7 VEGFB YWHAB YWHAG YWHAQ YWHAZ
Entrez ID		7423	7351
HPRD ID		03237	03410
Ensembl ID		ENSG00000173511	ENSG00000175567
Uniprot IDs		P49765 Q7LAP4	P55851
PDB IDs		2C7W 2VWE 2XAC 6TKK
Enriched GO Terms of Interacting Partners?		Adaptive Thermogenesis Vascular Endothelial Growth Factor Signaling Pathway VEGF-activated Neuropilin Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Sprouting Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Cold Neuropilin Signaling Pathway Oxidative Phosphorylation Uncoupler Activity Response To Superoxide Positive Regulation Of Axon Extension Involved In Axon Guidance Vascular Endothelial Growth Factor Receptor Activity Response To Oxygen Radical Coronary Artery Morphogenesis Coronary Vasculature Morphogenesis Endothelial Cell Chemotaxis Regulation Of MAPK Cascade Positive Regulation Of Cold-induced Thermogenesis Blood Vessel Morphogenesis Commissural Neuron Axon Guidance Motor Neuron Migration Chemotaxis Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Axon Extension Involved In Axon Guidance Locomotion Mitochondrial Transmembrane Transport Retinal Ganglion Cell Axon Guidance Regulation Of Cold-induced Thermogenesis Response To Temperature Stimulus Regulation Of Endothelial Cell Proliferation Proton Transmembrane Transporter Activity Cell Migration Involved In Sprouting Angiogenesis Heparin Binding Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Population Proliferation Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Angiogenesis Positive Regulation Of Vasculature Development Branching Involved In Blood Vessel Morphogenesis Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Receptor Complex Mitochondrial Transport Platelet-derived Growth Factor Receptor Signaling Pathway Blood Vessel Endothelial Cell Migration Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Cell Chemotaxis Positive Regulation Of Axon Extension Growth Factor Binding	Protein Domain Specific Binding Protein Targeting Protein Sequestering Activity Phosphoserine Residue Binding Identical Protein Binding Focal Adhesion Negative Regulation Of Protein Localization To Nucleus Cellular Response To Glucose Starvation Negative Regulation Of TORC1 Signaling TORC1 Signaling Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Melanosome Regulation Of TORC1 Signaling Negative Regulation Of TOR Signaling TOR Signaling Keratin Filament Synaptic Target Recognition Establishment Of Protein Localization Vascular Endothelial Growth Factor Receptor 1 Binding Negative Regulation Of Macromolecule Metabolic Process Protein Kinase C Inhibitor Activity Transmembrane Transporter Binding Vascular Endothelial Growth Factor Receptor Binding Negative Regulation Of Metabolic Process Regulation Of Protein Localization To Nucleus Regulation Of TOR Signaling Intermediate Filament Golgi Reassembly Vesicle Positive Regulation Of Vascular Wound Healing Positive Regulation Of Mast Cell Chemotaxis Cellular Response To Starvation Regulation Of Mast Cell Chemotaxis Intracellular Protein Localization Negative Regulation Of Protein Localization Negative Regulation Of Immune Response Response To Starvation Establishment Of Golgi Localization Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Phosphorylation-dependent Protein Binding Regulation Of Protein Localization Cellular Response To Nutrient Levels Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Cytosol Regulation Of ERK1 And ERK2 Cascade Regulation Of Vascular Wound Healing Extracellular Exosome Vacuolar Membrane Negative Regulation Of Immune Response To Tumor Cell
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