VAV1 and CBLB

Number of citations of the paper that reports this interaction (PubMedID 9399639)
0

Data Source:
BioGRID (far western blotting, affinity chromatography technology)
HPRD (in vivo)

		VAV1	CBLB
Description		vav guanine nucleotide exchange factor 1	Cbl proto-oncogene B
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Raft Postsynapse Glutamatergic Synapse
	Molecular Function	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Phosphorylation-dependent Protein Binding	Phosphotyrosine Residue Binding Ubiquitin-protein Transferase Activity Calcium Ion Binding Protein Binding Zinc Ion Binding Transferase Activity Receptor Tyrosine Kinase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Immune Response-regulating Cell Surface Receptor Signaling Pathway Phagocytosis Immune Response G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Small GTPase-mediated Signal Transduction Regulation Of Cell Size Response To Xenobiotic Stimulus Cell Migration Natural Killer Cell Activation Platelet Activation T Cell Differentiation Neutrophil Chemotaxis T Cell Costimulation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis B Cell Proliferation T Cell Activation Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Cell Adhesion Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Xenobiotic Stimulus Reactive Oxygen Species Metabolic Process	Positive Regulation Of T Cell Anergy T Cell Anergy NLS-bearing Protein Import Into Nucleus Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Protein Ubiquitination Regulation Of Signaling Regulation Of Cell Adhesion Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Intracellular Signal Transduction CD4-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway T Cell Activation Positive Regulation Of Protein Catabolic Process T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Regulation Protein Catabolic Process At Postsynapse Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
Pathways		GPVI-mediated activation cascade GPVI-mediated activation cascade PIP3 activates AKT signaling Signaling by SCF-KIT NRAGE signals death through JNK Regulation of actin dynamics for phagocytic cup formation Constitutive Signaling by Aberrant PI3K in Cancer FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization CD28 dependent Vav1 pathway G alpha (12/13) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling VEGFR2 mediated vascular permeability PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RHOA GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Potential therapeutics for SARS Azathioprine ADME Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Lymphocyte count ( 32888494) Mean platelet volume ( 27863252 32888494) Periodontitis ( 23459936) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494)	Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Antipsychotic drug-induced weight gain in schizophrenia or autism ( 31447353) Estimated glomerular filtration rate ( 31152163) Itch intensity from mosquito bite ( 28199695) Mosquito bite size ( 28199695) Multiple sclerosis ( 20453840 28445677 31604244) Waist circumference ( 31647587) Zinc levels ( 26025379)
Interacting Genes		83 interacting genes: ABL1 ACTA1 AOC3 AR ARHGDIA ARHGDIB BCR BLNK BTK CASP3 CBL CBLB CD19 CDC42 CFTR CRK CXCR4 DNM2 DOCK2 DOK1 EGFR EMD EPOR ERBB2 ERBB3 ERBB4 EZH2 FGFR1 FYN GAB1 GRB2 HCK HNRNPK HRAS IL6ST INSR JAK2 JUN KHDRBS1 LAT LCK LCP2 MAPK1 MERTK MET NEK3 PAG1 PDGFRB PHAX PIK3R1 PLCG1 PRKCQ PRLR PTK2B PTPN22 PTPN6 PTPRC RAC1 RACGAP1 RAF1 RHOA RHOG RIMS1 S100B SH3BP2 SHB SHC1 SIAH1 SIAH2 SLA SMARCA4 SOCS1 SYK TEC TUBA1A TUBA4A TUBB TYK2 XRCC5 XRCC6 ZAP70 ZNF655 ZYX	54 interacting genes: APPL1 ARHGEF7 BLNK CD2AP CRKL CRY1 DAPK1 DUXAP9 EGFR FLT3 FYB1 FYN GLRX3 GORASP2 GRAP2 GRB2 HNRNPK IFT57 KIT LRRK1 LRRK2 MFHAS1 NCK1 NCK2 NEDD4 NEDD8 OSTF1 PIK3R1 PLCG2 PRMT2 PTK6 RET RNF11 SH3KBP1 SH3RF1 SHC1 SORBS2 SORBS3 SP7 SPRY2 SYK TGFB1I1 TNFRSF11A UBASH3A UBASH3B UBC UBE2D2 UBE2L3 VAV1 VAV2 VAV3 VPS26C YES1 ZAP70
Entrez ID		7409	868
HPRD ID		01284	05136
Ensembl ID		ENSG00000141968	ENSG00000114423
Uniprot IDs		A0A0A0MR07 B2R8B5 P15498 Q96D37	B3KSS7 B4DYP3 B7ZAG1 Q13191
PDB IDs		2CRH 2LCT 2MC1 2ROR 3BJI 3KY9 6NEW 6NF1 6NFA	2AK5 2BZ8 2DO6 2J6F 2JNH 2LDR 2OOA 2OOB 3PFV 3VGO 3ZNI 8GCY 8QNG 8QNH 8QNI 8QTG 8QTH 8QTJ 8QTK 8VW4 8VW5 9FQH 9FQI 9FQJ
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Antigen Receptor-mediated Signaling Pathway Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Peptidyl-tyrosine Phosphorylation Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Immune System Process T Cell Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Immune System Process Regulation Of Immune System Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Lymphocyte Activation Positive Regulation Of Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Cell Population Proliferation Cellular Developmental Process Regulation Of Cell Activation Intracellular Signaling Cassette Activation Of Immune Response Regulation Of Cell Population Proliferation Positive Regulation Of Immune Response Cell Differentiation Protein Phosphorylation Positive Regulation Of MAPK Cascade Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Cell Adhesion Regulation Of Immune Response Phosphorylation Leukocyte Activation Protein Kinase Activity Regulation Of T Cell Activation Lymphocyte Activation Regulation Of Programmed Cell Death Developmental Process Positive Regulation Of Protein Phosphorylation Nucleotide Binding Regulation Of Apoptotic Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphotyrosine Residue Binding Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Migration Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Positive Regulation Of Immune System Process Antigen Receptor-mediated Signaling Pathway Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Cell Motility Positive Regulation Of Cell Communication Cytoplasm Positive Regulation Of Signaling Immune Response-activating Signaling Pathway Fc Receptor Signaling Pathway Activation Of Immune Response Regulation Of Immune Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Intracellular Signaling Cassette Cell Activation Fc Receptor Mediated Stimulatory Signaling Pathway Leukocyte Migration Protein Tyrosine Kinase Activity Fc-gamma Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Positive Regulation Of Immune Response Lymphocyte Activation Lamellipodium Assembly Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Lamellipodium Organization Regulation Of Cell Activation Fc-epsilon Receptor Signaling Pathway Leukocyte Activation Immune System Process Cytosol T Cell Activation Positive Regulation Of Cell Activation
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