UPK2 and KIR3DL3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UPK2	KIR3DL3
Description		uroplakin 2	killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome	Plasma Membrane Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Epithelial Cell Differentiation	Immune Response-regulating Signaling Pathway Cell Communication
Pathways
Drugs
Diseases
GWAS		Asthma ( 31959851)	Monocyte percentage of white cells ( 32888494)
Interacting Genes		36 interacting genes: ADGRG3 AMIGO1 ASGR2 ATP6AP2 BSCL2 BTNL9 C3orf52 CD74 CLDN7 CLEC17A CLEC7A CYB5R3 FCGR1A FCGR2A FCGRT FKBP7 FNDC9 GPA33 HPN ITM2C KASH5 KIR2DL3 KIR3DL3 LIME1 PLP1 RNF170 SLC18A1 SLC22A23 SMAGP STOML3 TMEM106C TMPRSS2 TNFSF11 TNFSF14 UPK1A ZNRF4	23 interacting genes: ADAM33 AGTRAP ASIC1 C5 CD53 CMTM5 CTXN3 EDDM3B EMP3 GIMAP5 JAGN1 LAPTM5 NINJ2 OLFM4 SERP1 SLC35A1 SLC41A2 SMIM3 SYS1 TAFA2 TNMD UPK2 VAMP5
Entrez ID		7379	115653
HPRD ID		10295	17236
Ensembl ID		ENSG00000110375	ENSG00000242019
Uniprot IDs		O00526	A0A8I5QEB2
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Immune Response-regulating Signaling Pathway External Side Of Plasma Membrane Immune System Process IgG Binding Immune Response Regulation Of Immune Response Regulation Of Immune System Process IgG Receptor Activity Regulation Of Non-canonical NF-kappaB Signal Transduction Pattern Recognition Receptor Activity Immunoglobulin Mediated Immune Response Fucose Binding B Cell Mediated Immunity Antibody-dependent Cellular Cytotoxicity Protein Binding Positive Regulation Of Immune System Process Endoplasmic Reticulum Endoplasmic Reticulum Membrane Hypersensitivity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Phagocytosis, Recognition Positive Regulation Of Immune Response Positive Regulation Of Viral Entry Into Host Cell Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Phagocytosis Acute Inflammatory Response To Antigenic Stimulus Immune Response-activating Signaling Pathway Regulation Of Viral Entry Into Host Cell D-mannose Binding Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Viral Life Cycle Regulation Of Phagocytosis Positive Regulation Of Acute Inflammatory Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Tumor Necrosis Factor Production MHC Class II Protein Binding, Via Antigen Binding Groove NOS2-CD74 Complex Macrophage Migration Inhibitory Factor Signaling Pathway Lymphocyte Mediated Immunity Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production High-affinity IgG Receptor Activity IgG Immunoglobulin Transcytosis In Epithelial Cells Mediated By FcRn Immunoglobulin Receptor Tumor Necrosis Factor Receptor Binding Eye Pigmentation Activation Of Immune Response Detection Of Yeast Detection Of Molecule Of Fungal Origin	Membrane Inorganic Cation Transmembrane Transporter Activity
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