UBE2G2 and TRIM43

Number of citations of the paper that reports this interaction (PubMedID 19690564)
61

Data Source:
BioGRID (two hybrid)

		UBE2G2	TRIM43
Description		ubiquitin conjugating enzyme E2 G2	tripartite motif containing 43
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Lipid Droplet Cytosol	Cytoplasm Centrosome Cytoskeleton
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Identical Protein Binding Ubiquitin Conjugating Enzyme Activity	Protein Binding Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Response To Interferon-beta ERAD Pathway Protein K48-linked Ubiquitination Negative Regulation Of Retrograde Protein Transport, ER To Cytosol	Regulation Of Gene Expression Innate Immune Response
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301)
Interacting Genes		43 interacting genes: AMFR ARL14 AUP1 BIRC8 CBL CNNM3 CPOX CUL9 ECPAS FARP2 HBS1L KDM2A MARCHF6 MDM2 MGRN1 MLLT6 MUL1 NDUFS4 POLR3F PRKN PSMG1 RBX1 RC3H1 RC3H2 RFFL RNF111 RNF146 RNF157 RNF167 RNF168 RNF26 RNF5 TMEM45B TRAPPC10 TRIM21 TRIM3 TRIM43 UBA6 UBC UBE2J2 UBE3A VAMP8 ZNRF4	11 interacting genes: ENOX1 GRB7 MYOG TRIM27 TRIM8 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G2 UBE2K
Entrez ID		7327	129868
HPRD ID		04387	15560
Ensembl ID		ENSG00000184787	ENSG00000144015
Uniprot IDs		P60604	Q96BQ3
PDB IDs		2CYX 2KLY 2LXP 3H8K 4LAD 7LEW 8T0S
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Post-translational Protein Modification Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Protein Modification Process Catabolic Process Zinc Ion Binding Transferase Activity Protein Metabolic Process Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Protein Catabolic Process Protein Autoubiquitination Metal Ion Binding Macromolecule Metabolic Process ERAD Pathway Protein K63-linked Ubiquitination Ubiquitin Protein Ligase Binding Protein Monoubiquitination Protein Destabilization Protein K6-linked Ubiquitination Cellular Response To Stress Positive Regulation Of Post-translational Protein Modification Response To Endoplasmic Reticulum Stress Regulation Of Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Response To Stress Endoplasmic Reticulum Mannose Trimming Ubiquitin Binding Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Protein Alpha-1,2-demannosylation Protein K27-linked Ubiquitination Ubiquitin-specific Protease Binding Protein Deglycosylation Positive Regulation Of Dendrite Extension Endoplasmic Reticulum Quality Control Compartment NEDD8 Ligase Activity Regulation Of Intracellular Signal Transduction Ubiquitin Conjugating Enzyme Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Modification Process Transferase Activity Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Activity Protein K63-linked Ubiquitination Macromolecule Catabolic Process Proteolysis Negative Regulation Of Viral Transcription Suppression Of Viral Release By Host Protein Metabolic Process Regulation Of Viral Transcription ATP Binding Cellular Response To Interferon-beta Protein K6-linked Ubiquitination Response To Interferon-beta Protein K11-linked Ubiquitination Nucleotide Binding Catabolic Process Negative Regulation Of BMP Signaling Pathway Protein Autoubiquitination Negative Regulation Of Viral Process Positive Regulation Of Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Ultradian Rhythm Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Cellular Response To Cytokine Stimulus PML Body Regulation Of BMP Signaling Pathway Macromolecule Metabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Proteasomal Protein Catabolic Process Regulation Of Viral Process Response To Cytokine Free Ubiquitin Chain Polymerization Response To Denervation Involved In Regulation Of Muscle Adaptation Striated Muscle Atrophy Phosphatidylinositol 3-kinase Inhibitor Activity Response To Peptide Response To Muscle Inactivity Positive Regulation Of Skeletal Muscle Fiber Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
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