UBE2B and TRIM14

Number of citations of the paper that reports this interaction (PubMedID 29053956)
0

Data Source:
BioGRID (two hybrid)

		UBE2B	TRIM14
Description		ubiquitin conjugating enzyme E2 B	tripartite motif containing 14
Image
GO Annotations	Cellular Component	Chromatin XY Body Nucleus Nucleoplasm Replication Fork Cytoplasm Plasma Membrane Membrane HULC Complex	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Membrane Cytoplasmic Vesicle Phagocytic Vesicle
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Metal Ion Binding Molecular Adaptor Activity Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination In Utero Embryonic Development DNA Repair Postreplication Repair Chromatin Organization Ubiquitin-dependent Protein Catabolic Process Apoptotic Process DNA Damage Response Spermatogenesis Sperm Axoneme Assembly Response To Xenobiotic Stimulus Response To UV Positive Regulation Of Reciprocal Meiotic Recombination Protein Ubiquitination Ectopic Germ Cell Programmed Cell Death Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Meiotic Telomere Clustering Protein Stabilization Chiasma Assembly Negative Regulation Of Developmental Process Protein Autoubiquitination Synaptonemal Complex Organization Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Post-translational Protein Modification Negative Regulation Of Reproductive Process	Immune System Process Inflammatory Response Negative Regulation Of Viral Transcription Innate Immune Response Positive Regulation Of DNA-templated Transcription Protein K48-linked Deubiquitination
Pathways		Recognition of DNA damage by PCNA-containing replication complex Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation	Interferon gamma signaling
Drugs
Diseases
GWAS		Relative amplitude of rest-activity cycles ( 30120083)	Multiple sclerosis ( 31604244)
Interacting Genes		30 interacting genes: BIRC2 CBX5 CDKN1B CNOT4 CRMP1 CTNNB1 FBN2 H2AC20 H2BC1 HERPUD2 MED31 PCNA PRKN RAD18 RC3H1 RC3H2 RNF167 RNF20 RNF4 RNF40 TRIM14 TRIM45 UBA1 UBA6 UBR1 UBR2 UBR3 UBR4 UBR5 UNC119	85 interacting genes: ABCF3 ADAMTS12 ALG13 AP3M1 ATP1B1 ATP1B3 ATP2A2 ATP5PB ATP6V1H BYSL CARD9 CCDC125 CCDC57 CCDC6 CENPC CIB3 CKS1B CSPP1 DHX58 EIF3G ERCC3 ETFBKMT EXOC8 FAM50B FAT1 GOLGA2 GOLGA6L9 HERC3 HEXIM2 HNRNPF IHO1 ITM2A IVNS1ABP KAT2B KIF3A KIFC3 LAMTOR1 LNX1 MAPRE3 MITD1 MNAT1 MRPL24 MYO15B NCOR1 NDUFA9 NFAT5 NPC2 PCGF6 PDIA6 PHF11 PIM2 PLCG1 POLR1C POLR2G PPP2R3C PRDM6 PRKAB2 PRPF31 PTPN21 RAB5A RAB9A RAD51D RBM33 RLF RNF125 RNF20 SLF2 SMARCB1 SMIM3 SPG21 STK38 TAX1BP1 TMEM167A TRAF2 TSGA10 UBE2B UBE2N UNK VIM WDR35 WRNIP1 ZC4H2 ZFP36L2 ZGPAT ZNF652
Entrez ID		7320	9830
HPRD ID		01533	05948
Ensembl ID		ENSG00000119048	ENSG00000106785
Uniprot IDs		P63146	Q14142
PDB IDs		1JAS 2Y4W 2YB6 2YBF	6JBM
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification Process Proteolysis Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Protein Polyubiquitination Catabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Zinc Ion Binding Transferase Activity Proteasomal Protein Catabolic Process Macromolecule Metabolic Process Protein Catabolic Process Protein K11-linked Ubiquitination Protein K48-linked Ubiquitination Protein K29-linked Ubiquitination Metal Ion Binding Cellular Response To Stress Protein Autoubiquitination Protein K63-linked Ubiquitination Ubiquitin Activating Enzyme Activity Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Ubiquitin Protein Ligase Binding Protein K6-linked Ubiquitination Response To Stress Cytoplasm Protein Quality Control Protein-containing Complex Binding HULC Complex DNA Damage Response Response To Amino Acid Positive Regulation Of Metabolic Process Placenta Development L-leucine Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Positive Regulation Of Macromolecule Metabolic Process Epithelial Cell Proliferation Involved In Prostate Gland Development Limb Development Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Ubiquitin-like Modifier Activating Enzyme Activity T Follicular Helper Cell Differentiation
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