CDK11A and B4GALT1

Number of citations of the paper that reports this interaction (PubMedID 11506180)
0

Data Source:
BioGRID (pull down)

		CDK11A	B4GALT1
Description		cyclin dependent kinase 11A	beta-1,4-galactosyltransferase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Cytoplasm	Golgi Trans Cisterna Golgi Membrane Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Desmosome Filopodium Secretory Granule Membrane Brush Border Membrane Golgi Cisterna Membrane Protein-containing Complex Azurophil Granule Membrane Cell Projection Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity N-acetyllactosamine Synthase Activity Lactose Synthase Activity Galactosyltransferase Activity Transferase Activity Glycosyltransferase Activity Manganese Ion Binding UDP-galactosyltransferase Activity Identical Protein Binding Alpha-tubulin Binding Metal Ion Binding Beta-tubulin Binding
	Biological Process	Mitotic Cell Cycle Regulation Of Cell Growth Regulation Of DNA-templated Transcription Protein Phosphorylation Apoptotic Process Regulation Of Apoptotic Process Regulation Of RNA Splicing Regulation Of Centrosome Cycle Regulation Of MRNA Processing Regulation Of Cell Cycle	Epithelial Cell Development Acute Inflammatory Response Carbohydrate Metabolic Process Lactose Biosynthetic Process Galactose Metabolic Process Protein Glycosylation Protein N-linked Glycosylation Lipid Metabolic Process Cell Adhesion Binding Of Sperm To Zona Pellucida Penetration Of Zona Pellucida Cell Population Proliferation Glycoprotein Biosynthetic Process Oligosaccharide Biosynthetic Process Extracellular Matrix Organization Wound Healing Positive Regulation Of Apoptotic Process Development Of Secondary Sexual Characteristics Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Acrosome Reaction Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Angiogenesis Involved In Wound Healing Positive Regulation Of Circulating Fibrinogen Levels Macrophage Migration
Pathways		Recruitment of mitotic centrosome proteins and complexes	Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Interaction With Cumulus Cells And The Zona Pellucida Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective B4GALT1 causes CDG-2d Lactose synthesis Neutrophil degranulation N-Glycan antennae elongation
Drugs			N-Acetylglucosamine 6-Aminohexyl-uridine-C1,5'-diphosphate 4)-N-acetyl-beta-D-glucosamine Galactose-uridine-5'-diphosphate Uridine monophosphate 2-(N-morpholino)ethanesulfonic acid
Diseases			Congenital disorders of glycosylation (CDG) type II
GWAS		Body mass index ( 26426971)	Aspartate aminotransferase levels ( 33547301 33339817 29403010) Blood protein levels ( 30072576) Hematocrit ( 32888494) Hemoglobin ( 32888494) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392 32128391) Influenza A (H1N1) infection ( 26379185) Iron status biomarkers (ferritin levels) ( 33536631) Mild influenza (H1N1) infection ( 26379185) N-glycan levels ( 31163085) Red blood cell count ( 32888494) Serum uric acid levels ( 30993211) Severe influenza A (H1N1) infection ( 26379185) Urate levels ( 31578528 31985003 23263486)
Interacting Genes		7 interacting genes: B4GALT1 CCNL1 GADD45A GADD45G PIN1 SKIC2 SPDEF	10 interacting genes: CCL19 CDK11A EGFR LALBA OR10G4 SNCA TFRC TUBA1A TUBA4A TUBB
Entrez ID		728642	2683
HPRD ID			00659
Ensembl ID		ENSG00000008128	ENSG00000086062
Uniprot IDs		Q4VBY6 Q5QPR3 Q9UQ88	B7ZAH9 P15291 Q86XA6 W6MEN3
PDB IDs			2AE7 2AEC 2AES 2AGD 2AH9 2FY7 2FYA 2FYB 3EE5 4EE3 4EE4 4EE5 4EEA 4EEG 4EEM 4EEO 4L41 6FWT 6FWU
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of P38MAPK Cascade Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of P38MAPK Cascade Regulation Of Cell Cycle Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Positive Regulation Of Circulating Fibrinogen Levels Cis-trans Isomerase Activity Nuclear Speck Positive Regulation Of JNK Cascade Epithelial Cell Development Lactose Biosynthetic Process UDP-galactosyltransferase Activity Lactose Synthase Activity Protein Peptidyl-prolyl Isomerization Phosphothreonine Residue Binding Ski Complex Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay Lung Goblet Cell Differentiation Regulation Of JNK Cascade N-acetyllactosamine Synthase Activity Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity Regulation Of MAPK Cascade Glandular Epithelial Cell Development Development Of Secondary Sexual Characteristics Phosphoserine Residue Binding Negative Regulation Of Peptidyl-serine Phosphorylation Galactosyltransferase Activity 3'-5' RNA Helicase Activity Golgi Trans Cisterna Disaccharide Metabolic Process Galactose Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Penetration Of Zona Pellucida Mitogen-activated Protein Kinase Kinase Binding Intestinal Epithelial Cell Development GTPase Activating Protein Binding Ubiquitin Ligase Activator Activity Epithelial Cell Fate Commitment Positive Regulation Of Cell Fate Commitment Regulation Of Acrosome Reaction Negative Regulation Of Cell Fate Commitment	Mitotic Cell Cycle Structural Constituent Of Cytoskeleton Extracellular Region Regulation Of Cellular Component Organization Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Clathrin-coated Endocytic Vesicle Membrane Positive Regulation Of Protein Localization To Cell Periphery Response To Lipid Protein-containing Complex Virus Receptor Activity Negative Regulation Of Apoptotic Process Shc-EGFR Complex Extracellular Space Multivesicular Body, Internal Vesicle Lumen Lactose Biosynthetic Process CCR7 Chemokine Receptor Binding CCL19-activated CCR7 Signaling Pathway Positive Regulation Of Dendritic Cell Dendrite Assembly Response To Desipramine Response To Iron Ion Adult Locomotory Behavior Negative Regulation Of Norepinephrine Uptake Response To Copper Ion Response To Metal Ion Regulation Of Synapse Organization Phospholipase D Inhibitor Activity Regulation Of Norepinephrine Uptake Positive Regulation Of SNARE Complex Assembly Receptor Internalization Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Hsp70 Protein Binding Transferrin Receptor Activity Protein-containing Complex Binding Microtubule Microtubule Cytoskeleton GTP Binding Cytoplasmic Ribonucleoprotein Granule Apoptotic Process Negative Regulation Of Programmed Cell Death Nucleotide Binding Enzyme Binding Regulation Of Cell Growth Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Cell Death Programmed Cell Death Lactose Synthase Activity
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