TTR and SETDB1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		TTR	SETDB1
Description		transthyretin	SET domain bifurcated histone lysine methyltransferase 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Protein-containing Complex Azurophil Granule Lumen Extracellular Exosome	Nucleus Nucleoplasm Chromosome Cytoplasm
	Molecular Function	Hormone Activity Protein Binding Hormone Binding Identical Protein Binding Protein-containing Complex Binding Molecular Sequestering Activity	DNA Binding Chromatin Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity Histone H3K9 Monomethyltransferase Activity Histone H3K9 Trimethyltransferase Activity Promoter-specific Chromatin Binding
	Biological Process	Retinoid Metabolic Process Negative Regulation Of Glomerular Filtration Purine Nucleobase Metabolic Process Phototransduction, Visible Light	Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Negative Regulation Of Gene Expression Methylation Heterochromatin Organization Transposable Element Silencing By Heterochromatin Formation
Pathways		The canonical retinoid cycle in rods (twilight vision) Non-integrin membrane-ECM interactions Neutrophil degranulation Retinoid metabolism and transport Amyloid fiber formation Defective visual phototransduction due to STRA6 loss of function	PKMTs methylate histone lysines Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Drugs		Zinc Copper Tafamidis Zinc acetate Zinc chloride Zinc sulfate, unspecified form Revusiran
Diseases		Familial carpal tunnel syndrome Familial amyloidosis
GWAS		Retinol levels ( 21878437)	Body mass index ( 26426971) Caffeine consumption from coffee or tea ( 33287642) Caffeine consumption from tea ( 33287642) Chronic kidney disease ( 20383146) Coffee consumption ( 31046077) Cutaneous squamous cell carcinoma ( 32041948) Hip circumference adjusted for BMI ( 34021172) Melanoma ( 21983785) Neurological blood protein biomarker levels ( 31320639) Nevus count or cutaneous melanoma ( 30429480)
Interacting Genes		50 interacting genes: A2M ACTB AGER APOA1 ATF4 ATF5 BAG6 CDR2 CEP126 CFTR CHD3 CLU CPNE6 CTNND2 DDR1 EEF1A1 ELP1 ERG28 FEZ1 GET3 GET4 HNRNPH3 HSP90AA1 HSPG2 INPP5K LRP2 MARK3 MT3 NDUFA5 NECAB2 NGFR OTUB1 PHYHIP PIK3R1 PRKCI QARS1 RAI1 RBP4 RNF115 SDF4 SETDB1 SP110 ST13 ST3GAL3 SUMO3 TAF1C TAF5L TUBA1A VIM ZBED1	111 interacting genes: AIFM1 AKT1 ANXA7 APC APLP1 ASAH1 ATF7IP ATF7IP2 BAG6 BARD1 BHLHE40 BID BRIX1 BTBD2 BTG3 CBX8 CCDC106 CDK4 CDKN1A CFAP68 CLSTN1 CREBBP CRELD1 DAP DLEU1 DNMT3A ECSIT ERG ERH FAM118B FLYWCH1 GIPC2 GPS2 GRB7 GSTO1 H3-4 H3C1 H3C15 H4C16 HDAC1 HDAC2 HMOX2 HSPB3 JARID2 KDM1A LRIF1 LUC7L2 MAD2L1BP MAP4K5 MBD1 MDM2 MOB4 MRPL44 MZT2B NIPSNAP3A OLFML3 ORAI2 PABPC4 PAFAH1B3 PCDHA4 PCYT2 PGAM5 PHF10 PIAS4 PLEKHA4 POLA2 PPA1 PPP1R8 PRKRA PSMD11 PSME1 PTPRS QTRT1 RIF1 RNF10 S100A10 SAT1 SERPINB9 SIN3A SIN3B SKIL SLC38A3 SMN1 SNIP1 SUFU SULT1E1 SUMO2 TARDBP TCERG1 THAP8 TK1 TOB1 TOLLIP TPI1 TRBV2 TRDMT1 TRIB3 TRIM16 TRIM28 TRIP6 TSC22D1 TSPAN15 TTR TXNDC9 UBE2I ULK2 USP11 VHL VIM ZFP64 ZNF24
Entrez ID		7276	9869
HPRD ID		01447	06828
Ensembl ID		ENSG00000118271	ENSG00000143379
Uniprot IDs		E9KL36 P02766	A0A8I5KT93 Q15047 X6R732
PDB IDs		1BM7 1BMZ 1BZ8 1BZD 1BZE 1DVQ 1DVS 1DVT 1DVU 1DVX 1DVY 1DVZ 1E3F 1E4H 1E5A 1ETA 1ETB 1F41 1F86 1FH2 1FHN 1G1O 1GKO 1ICT 1III 1IIK 1IJN 1QAB 1QWH 1RLB 1SOK 1SOQ 1THA 1THC 1TLM 1TSH 1TT6 1TTA 1TTB 1TTC 1TTR 1TYR 1TZ8 1U21 1X7S 1X7T 1Y1D 1Z7J 1ZCR 1ZD6 2B14 2B15 2B16 2B77 2B9A 2F7I 2F8I 2FBR 2FLM 2G3X 2G3Z 2G4E 2G4G 2G5U 2G9K 2GAB 2H4E 2M5N 2NBO 2NBP 2NOY 2PAB 2QEL 2QGB 2QGC 2QGD 2QGE 2ROX 2ROY 2TRH 2TRY 2WQA 3A4D 3A4E 3A4F 3B56 3BSZ 3BT0 3CBR 3CFM 3CFN 3CFQ 3CFT 3CN0 3CN1 3CN2 3CN3 3CN4 3CXF 3D2T 3D7P 3DGD 3DID 3DJR 3DJS 3DJT 3DJZ 3DK0 3DK2 3DO4 3ESN 3ESO 3ESP 3FC8 3FCB 3GLZ 3GPS 3GRB 3GRG 3GS0 3GS4 3GS7 3HJ0 3I9A 3I9I 3I9P 3IMR 3IMS 3IMT 3IMU 3IMV 3IMW 3IPB 3IPE 3KGS 3KGT 3KGU 3M1O 3NEE 3NEO 3NES 3NEX 3NG5 3OZK 3OZL 3P3R 3P3S 3P3T 3P3U 3SSG 3TCT 3TFB 3U2I 3U2J 3W3B 4ABQ 4ABU 4ABV 4ABW 4AC2 4AC4 4ACT 4ANK 4D7B 4DER 4DES 4DET 4DEU 4DEW 4FI6 4FI7 4FI8 4HIQ 4HIS 4HJS 4HJT 4HJU 4I85 4I87 4I89 4IIZ 4IK6 4IK7 4IKI 4IKJ 4IKK 4IKL 4KY2 4L1S 4L1T 4MAS 4MRB 4MRC 4N85 4N86 4N87 4PM1 4PME 4PMF 4PVL 4PVM 4PVN 4PWE 4PWF 4PWG 4PWH 4PWI 4PWJ 4PWK 4QRF 4QXV 4QYA 4TKW 4TL4 4TL5 4TLK 4TLS 4TLT 4TLU 4TM9 4TNE 4TNF 4TNG 4TQ8 4TQH 4TQI 4TQP 4WNJ 4WNS 4WO0 4Y9B 4Y9C 4Y9E 4Y9F 4Y9G 4YDM 4YDN 5A6I 5AKS 5AKT 5AKV 5AL0 5AL8 5AYT 5BOJ 5CLX 5CLY 5CLZ 5CM1 5CN3 5CNH 5CR1 5DEJ 5DWP 5E23 5E4A 5E4O 5EN3 5EZP 5FO2 5FW6 5FW7 5FW8 5H0V 5H0W 5H0X 5H0Y 5H0Z 5HJG 5IHH 5JID 5JIM 5JIQ 5K1J 5K1N 5L4F 5L4I 5L4J 5L4M 5LLL 5LLV 5N5Q 5N62 5N7C 5NFE 5NFW 5OQ0 5TTR 5TZL 5U48 5U49 5U4A 5U4B 5U4C 5U4D 5U4E 5U4F 5U4G 6D0W 6E6Z 6E70 6E71 6E72 6E73 6E74 6E75 6E76 6E77 6E78 6EOY 6EP1 6FFT 6FWD 6FXU 6FZL 6GR7 6GRP 6IMX 6IMY 6KGB 6R66 6R67 6R68 6R6I 6SDZ 6SUG 6SUH 6TI9 6TJN 6TXV 6TXW 6U0Q 6XTK 7ACU 7DT3 7DT5 7DT6 7DT8 7EJQ 7EJR 7ERH 7ERI 7ERJ 7ERK 7OB4 7Q3I 7Q9L 7Q9N 7Q9O 7QC5 7THA 7W9Q 7W9R 7WL6 7Y1I 7Y6J 7YBR 7YCQ 7Z60 8ADE 8AWI 8AWW 8C85 8C86 8E7D 8E7E 8E7H 8E7I 8E7J 8G9R 8GBR 8HEJ 8HY4 8I00 8I0O 8IG1 8II1 8II2 8II3 8II4 8JNU 8JOK 8JQW 8PKE 8PKF 8PKG 8PM8 8PM9 8PMA 8PMO 8T5X 8TDN 8TDO 8U52 8VE0 8VE1 8VE2 8VE3 8VE4 8VE5 8VE6 8W1N 8W2W 8W42 8W43 8W44 8W45 8W46 8W47 8W48 8WGS 8WGT 8WGU 8YQD 9BYN 9BZS 9H7A 9H7B 9H7C 9H7D 9H7E 9H7F 9H7G 9H7H 9H7I 9H7J 9H7K 9H7L 9H7M 9H7N 9H7O 9H7P 9JIQ 9JIR 9JIS	3DLM 4X3S 5KCH 5KCO 5KE2 5KE3 5KH6 5QT1 5QT2 6AU2 6AU3 6BHD 6BHE 6BHG 6BHH 6BHI 6BPI 7C9N 7CAJ 7CD9 7CJT 8G5E 8IYA 8UWP 9CUW 9CUX
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Protein Carrier Chaperone Amyloid-beta Binding Tau Protein Binding Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Transport Cytoplasm BAT3 Complex Regulation Of Protein Localization Maintenance Of Unfolded Protein Protein Stabilization Protein Binding Regulation Of Protein Stability Protein Insertion Into ER Membrane Regulation Of Protein Localization To Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Localization Regulation Of Primary Metabolic Process Negative Regulation Of Neuron Apoptotic Process Regulation Of Cellular Response To Stress Axon Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Cellular Response To Oxygen-containing Compound Negative Regulation Of Cellular Component Organization Cell Projection Regulation Of Programmed Cell Death Nitric-oxide Synthase Regulator Activity Regulation Of Metabolic Process Cell Projection Organization Spherical High-density Lipoprotein Particle Sterol Biosynthetic Process Negative Regulation Of Programmed Cell Death Protein-folding Chaperone Binding Vitamin Transport Positive Regulation Of Protein Localization Carbohydrate Homeostasis Glucose Homeostasis Vagina Development Blood Microparticle Cellular Response To Amyloid-beta Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Brush Border Regulation Of Multicellular Organismal Development Response To Endoplasmic Reticulum Stress Circadian Rhythm Kinase Activator Activity ATP Hydrolysis Activity Developmental Process Negative Regulation Of Complement Activation	Transcription Corepressor Activity Nucleus Nucleoplasm Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic SUMO Transferase Activity Regulation Of RNA Metabolic Process Chromatin Remodeling Epigenetic Regulation Of Gene Expression Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Response To Stress Chromatin Organization Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Transcription Coregulator Activity Constitutive Heterochromatin Formation Cytoplasm MRF Binding Chromatin Binding Transcription Regulator Complex DNA Methylation-dependent Constitutive Heterochromatin Formation Ubiquitin Protein Ligase Binding Sin3-type Complex Regulation Of Mitotic Cell Cycle Phase Transition Heterochromatin Protein Sumoylation Nuclear Matrix Nuclear Body RNA Binding Regulation Of Intrinsic Apoptotic Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Proteolysis Krueppel-associated Box Domain Binding Enzyme Binding
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