TTPA and SCAMP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TTPA	SCAMP1
Description		alpha tocopherol transfer protein	secretory carrier membrane protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Late Endosome Cytosol	Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Synaptic Vesicle Membrane Trans-Golgi Network Membrane Specific Granule Membrane Zymogen Granule Membrane Synapse Recycling Endosome Membrane
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Vitamin E Binding Phosphatidylinositol-3,4-bisphosphate Binding Lipid Transfer Activity Phosphatidylinositol Bisphosphate Binding	Protein Binding Protein Domain Specific Binding
	Biological Process	Placenta Development Embryonic Placenta Development Lipid Metabolic Process Response To Toxic Substance Vitamin E Metabolic Process Vitamin Transport Negative Regulation Of Establishment Of Blood-brain Barrier Intermembrane Lipid Transfer Positive Regulation Of Amyloid-beta Clearance	Exocytosis Post-Golgi Vesicle-mediated Transport Endocytosis Protein Transport Establishment Of Localization In Cell
Pathways		Vitamin E transport	Neutrophil degranulation
Drugs
Diseases		Ataxia with isolated vitamin E deficiency (AVED); Friedreich-like ataxia
GWAS		Response to esketamine (responder status) in treatment resistant depression ( 32724131) Response to esketamine in treatment resistant depression ( 32724131)	Hippocampal atrophy ( 19668339) Intraocular pressure ( 29785010) Platelet count ( 32888494) Plateletcrit ( 32888494) Triglycerides ( 26780889)
Interacting Genes		47 interacting genes: AGTRAP APOA5 APOC2 APP ARFIP2 ARMC12 BIRC7 CISD2 CMTM4 CMTM5 COQ3 CYSRT1 DGAT2L6 DHODH FADS6 FAM114A2 FAM25A FAM25C FAM25G FGF14 FKBP7 GOLGA2 HSD17B11 JOSD2 KRTAP10-7 KRTAP12-2 KRTAP12-3 KRTAP2-3 KRTAP2-4 LEUTX MAL2 MMS22L MRM1 NBPF19 NDUFA7 NOTCH2NLA PEX12 REEP2 RPRM SAR1A SCAMP1 SCAMP5 SDR16C5 SLC35E3 SYNGR3 THAP4 TPD52	28 interacting genes: ARFIP1 ARFIP2 CFTR EGFR EPS15 GAD2 ITSN1 KRTAP13-1 MTERF3 NDRG4 PBX3 PCYT1A PTPN9 SCAMP2 SLC9A7 SNAP23 SNAP25 SNCA SPG21 SYNRG TASOR2 TBRG4 THAP4 TP53 TRAF1 TTPA UBE3A ZMIZ2
Entrez ID		7274	9522
HPRD ID		02685	06072
Ensembl ID		ENSG00000137561	ENSG00000085365
Uniprot IDs		P49638	A0A087WXB0 B4E2V7 O15126
PDB IDs		1OIP 1OIZ 1R5L 5MUE 5MUG 6ZPD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Very-low-density Lipoprotein Particle Lipoprotein Lipase Activator Activity High-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Intermediate Filament Lipoprotein Metabolic Process Keratin Filament Positive Regulation Of Triglyceride Catabolic Process Trans-Golgi Network Membrane Triglyceride-rich Lipoprotein Particle Remodeling Chylomicron Phospholipid Efflux	Synaptic Vesicle Priming Regulation Of Golgi Lumen Acidification Cytosol Vesicle-mediated Transport In Synapse Exocytosis Import Into Cell Regulation Of Protein Localization Establishment Of Localization In Cell Postsynaptic Endocytic Zone Vesicle Docking Establishment Of Protein Localization Embryonic Organ Development Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Endosome Positive Regulation Of Receptor Recycling Organelle Localization By Membrane Tethering Positive Regulation Of Protein Localization To Cell Periphery Protein Transport Locomotory Behavior Synaptic Vesicle Membrane Organization Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Cellular PH Membrane Docking Regulation Of Intracellular PH Vesicle-mediated Transport Secretion By Cell Intracellular Vesicle Regulation Of PH Recycling Endosome Membrane Post-Golgi Vesicle-mediated Transport Positive Regulation Of Protein Localization Endocytosis Regulation Of Receptor Recycling Embryonic Placenta Development Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Trans-Golgi Network Membrane Regulation Of Arp2/3 Complex-mediated Actin Nucleation Golgi Apparatus Neurotransmitter Uptake Phospholipid Binding Phosphatidylinositol-4-phosphate Binding 14-3-3 Protein Binding Regulation Of Cellular Localization Recycling Endosome Positive Regulation Of Signaling Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Multivesicular Body, Internal Vesicle Lumen
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