TSG101 and CHD7

Number of citations of the paper that reports this interaction (PubMedID 35044719)
104

Data Source:
BioGRID (unspecified method)

		TSG101	CHD7
Description		tumor susceptibility 101	chromodomain helicase DNA binding protein 7
Image
GO Annotations	Cellular Component	ESCRT I Complex Nucleus Nucleolus Cytoplasm Endosome Early Endosome Late Endosome Multivesicular Body Centrosome Cytosol Cytoskeleton Plasma Membrane Endosome Membrane Membrane Early Endosome Membrane Late Endosome Membrane Extracellular Exosome Flemming Body	Chromatin Nucleus Nucleoplasm Nucleolus
	Molecular Function	DNA Binding Transcription Corepressor Activity Protein Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Binding Protein-containing Complex Binding Virion Binding Calcium-dependent Protein Binding	Nucleotide Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Histone Binding ATP-dependent Chromatin Remodeler Activity Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Extracellular Transport Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Cell Population Proliferation Endosome To Lysosome Transport Protein Transport Macroautophagy Viral Release From Host Cell Cell Differentiation Keratinocyte Differentiation Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of MAP Kinase Activity Viral Budding Cell Division Regulation Of Cell Cycle Membrane Fission Autophagosome Maturation Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Exosome Assembly Positive Regulation Of Viral Budding Via Host ESCRT Complex Exosomal Secretion Positive Regulation Of Ubiquitin-dependent Endocytosis	Skeletal System Development Blood Vessel Development In Utero Embryonic Development Blood Vessel Remodeling Heart Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Right Ventricular Compact Myocardium Morphogenesis Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription RRNA Processing Transcription By RNA Polymerase II Central Nervous System Development Adult Heart Development Sensory Perception Of Sound Locomotory Behavior Adult Walking Behavior Blood Circulation Response To Bacterium Regulation Of Gene Expression Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cranial Nerve Development Olfactory Nerve Development Olfactory Bulb Development T Cell Differentiation Female Genitalia Development Embryonic Hindlimb Morphogenesis Aorta Development Aorta Morphogenesis Atrioventricular Canal Development Positive Regulation Of Multicellular Organism Growth Olfactory Behavior Ear Morphogenesis Inner Ear Morphogenesis Chordate Embryonic Development Camera-type Eye Development Nose Development Positive Regulation Of Transcription By RNA Polymerase II Semicircular Canal Morphogenesis Tissue Remodeling Genitalia Development Artery Morphogenesis Regulation Of Neurogenesis Nervous System Process Cognition Regulation Of Transport Roof Of Mouth Development Retina Development In Camera-type Eye Regulation Of Growth Hormone Secretion Limb Development Head Development Face Development Innervation Cardiac Septum Morphogenesis Epithelium Development Secondary Palate Development
Pathways		Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy
Drugs
Diseases			Hypogonadotropic hypogonadism; Kallmann syndrome (KAL) CHARGE syndrome
GWAS			Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252 32888494) Eosinophil count ( 32888494 27863252 29403010) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 28552196) Lymphocyte percentage of white cells ( 27863252 32888494) Menopause (age at onset) ( 26414677) Monocyte percentage of white cells ( 27863252 32888494) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 29403010 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252 32888494) Pulmonary function decline ( 22424883) Refractive error ( 32231278 23396134) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic sclerosis ( 31672989) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31511532) White blood cell count ( 29403010 27863252 32888494)
Interacting Genes		136 interacting genes: AATF ADRB2 AJUBA AKAP9 AR BAG4 BCAS3 BCR BIRC2 CAGE1 CBY1 CCDC88B CCHCR1 CCND3 CDKN1A CDKN2D CDS2 CEP55 CEP63 CHD7 CNOT7 DAXX DMAP1 DMRTB1 DNMT1 DSCR9 DZIP3 EP300 FAM110A FAM9B GGA1 GGA3 GLI2 GLIS3 GMCL1 GOLM1 GPRC5B GUCY1B2 HAUS1 HCK HGS HSH2D INCA1 IQGAP1 IRF2BPL ITPRID2 ITSN1 JUN KIAA1328 KIF5A KIFC3 KLK5 KLK6 KRT13 KRT15 KRT16 KRT18 KRT31 KRT34 KRT35 KRT75 LCN2 LENG8 LNX1 LRRFIP1 LRSAM1 MDM2 MGRN1 MKRN3 MTA3 MZB1 NR3C1 NUP214 OGT PDCD6IP PDLIM7 PIAS1 PIP4P2 PKNOX2 PPFIBP2 PPP1R13B PRDM16 PRRC1 PRSS50 QKI RAD18 RASL10B RBPMS RNF111 RNF126 RNF41 ROCK1 SCAMP3 SCARA5 SCGB3A1 SCNN1A SH3GLB2 SHANK3 SNAPIN SNCA SNF8 SNX32 STK11 SYCE1 TAX1BP1 TEX11 TFF1 TFIP11 THRB THRSP TNF TNIP2 TNNT3 TOM1L1 TP53 TRAIP TRIM23 TRIM35 TRIM46 TRIM54 TRIM74 TRIML2 UBA52 UBC USF3 USHBP1 VPS11 VPS28 VPS36 VPS37A VPS37B VPS37C VPS37D WASHC1 YLPM1 ZWINT	4 interacting genes: CHD8 CTCF GGH TSG101
Entrez ID		7251	55636
HPRD ID		03229	10595
Ensembl ID		ENSG00000074319	ENSG00000171316
Uniprot IDs		Q99816	Q6ZWF9 Q9P2D1
PDB IDs		1KPP 1KPQ 1M4P 1M4Q 1S1Q 2F0R 3IV1 3OBQ 3OBS 3OBU 3OBX 3P9G 3P9H 4EJE 4YC1 4ZNY 5VKG 6UD0 6VME 7NLC 7ZLX	2CKC 2V0E 2V0F
Enriched GO Terms of Interacting Partners?		Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Organization Multivesicular Body Assembly Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Endosome Transport Via Multivesicular Body Sorting Pathway Vacuolar Transport Ubiquitin Protein Ligase Activity Multivesicular Body Sorting Pathway Autophagy Cytosol Late Endosome To Vacuole Transport Viral Budding Endosome Organization Establishment Of Protein Localization To Vacuole Intracellular Protein Localization Membrane Fission Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Localization To Vacuole Organelle Organization ESCRT I Complex Viral Budding Via Host ESCRT Complex Programmed Cell Death Cell Death Endosomal Transport Intracellular Protein Transport Macroautophagy Zinc Ion Binding Protein Ubiquitination Protein Transport Vesicle-mediated Transport Protein Modification By Small Protein Conjugation Apoptotic Process Establishment Of Protein Localization Cellular Localization Cytoplasm Cytoskeleton Structural Constituent Of Skin Epidermis Endosome Membrane Protein Binding Intracellular Transport Protein Localization To Organelle Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Ubiquitin Binding Intermediate Filament Organization Positive Regulation Of Catabolic Process Regulation Of Protein Metabolic Process Viral Process Post-translational Protein Modification	Exosomal Secretion Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Extracellular Exosome Assembly Positive Regulation Of Ubiquitin-dependent Endocytosis Positive Regulation Of Viral Budding Via Host ESCRT Complex Exopeptidase Activity Gamma-glutamyl-peptidase Activity Omega Peptidase Activity Tetrahydrofolylpolyglutamate Metabolic Process Chromatin Insulator Sequence Binding Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Chromatin Loop Anchoring Activity Regulation Of Centromeric Sister Chromatid Cohesion Chordate Embryonic Development In Utero Embryonic Development Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Fibroblast Apoptotic Process Virion Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process ESCRT I Complex Negative Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Signaling Receptor Activity Prepulse Inhibition Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Vacuole Chromatin Binding Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Regulation Of Sister Chromatid Cohesion Chromatin Looping Positive Regulation Of Transcription By RNA Polymerase III Regulation Of Fibroblast Apoptotic Process ATP-dependent Chromatin Remodeler Activity Startle Response Viral Budding Via Host ESCRT Complex Regulation Of Protein Tyrosine Kinase Activity Genomic Imprinting Histone H3K4me3 Reader Activity Positive Regulation Of Viral Life Cycle Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Flemming Body Regulation Of Signaling Receptor Activity Negative Regulation Of Macromolecule Biosynthetic Process Protein Localization To Organelle
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