TRPC6 and TRPM2

Number of citations of the paper that reports this interaction (PubMedID 12032305)
37

Data Source:
HPRD (in vitro, in vivo)

		TRPC6	TRPM2
Description		transient receptor potential cation channel subfamily C member 6	transient receptor potential cation channel subfamily M member 2
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Cation Channel Complex Slit Diaphragm	Lysosome Lysosomal Membrane Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Specific Granule Membrane Cell Projection Perikaryon Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Actin Binding Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Clathrin Binding Protein Homodimerization Activity Actinin Binding ATPase Binding Inositol 1,4,5 Trisphosphate Binding	Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Sodium Channel Activity Manganese Ion Transmembrane Transporter Activity Calcium Ion Binding Intracellularly Gated Calcium Channel Activity Hydrolase Activity Metal Ion Binding Metal Ion Transmembrane Transporter Activity ADP-ribose Diphosphatase Activity Mono-ADP-D-ribose Binding Ligand-gated Calcium Channel Activity
	Biological Process	Monoatomic Ion Transport Monoatomic Cation Transport Calcium Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Single Fertilization Neuron Differentiation Positive Regulation Of Ion Transmembrane Transporter Activity Monoatomic Ion Transmembrane Transport Positive Regulation Of Neuron Differentiation Negative Regulation Of Dendrite Morphogenesis Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Calcium Ion Transport Transmembrane Transport Cellular Response To Hydrogen Peroxide Calcium Ion Transmembrane Transport Cellular Response To Hypoxia	Temperature Homeostasis Dendritic Cell Chemotaxis Monoatomic Ion Transport Sodium Ion Transport Calcium Ion Transport Manganese Ion Transport Response To Heat Response To Purine-containing Compound Calcium-mediated Signaling Regulation Of Actin Cytoskeleton Organization Response To Hydroperoxide Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Regulation Of Filopodium Assembly Transmembrane Transport Cellular Response To Hydrogen Peroxide Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Manganese Ion Transmembrane Transport Cellular Response To Temperature Stimulus Zinc Ion Transmembrane Transport Dendritic Cell Differentiation Calcium Ion Transmembrane Import Into Cytosol Calcium Ion Import Across Plasma Membrane
Pathways		Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels TRP channels Role of second messengers in netrin-1 signaling	TRP channels Neutrophil degranulation
Drugs
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Change in LVEF in response to paclitaxel and trastuzumab in HER2+ breast cancer ( 28763429) Daytime nap ( 33568662) DHEAS levels ( 34748635) Femur bone mineral density x serum urate levels interaction ( 34046847) General risk tolerance (MTAG) ( 30643258) Lung adenocarcinoma ( 28604730) Menarche (age at onset) ( 25231870) Monocyte count ( 32888494) Plateletcrit ( 32888494) Severity of nausea and vomiting of pregnancy ( 29563502) White blood cell count ( 32888494)	Anorectal malformation ( 31136621) Dental caries (decayed, missing and filled teeth) ( 31533690) Parkinson's disease ( 32201043)
Interacting Genes		9 interacting genes: FYN ITPR3 MX1 ORAI1 RNF24 SRC TRPC3 TRPC7 TRPM2	4 interacting genes: EFHC1 ITPR3 TRAPPC10 TRPC6
Entrez ID		7225	7226
HPRD ID		04710	04777
Ensembl ID		ENSG00000137672	ENSG00000142185
Uniprot IDs		Q9Y210	B4DVI8 E9PGK7 O94759 Q14DR2
PDB IDs		5YX9 6UZ8 6UZA 7A6U 7DXF 7DXG	6MIX 6MIZ 6MJ2 6PUO 6PUR 6PUS 6PUU 7VQ1 7VQ2 8E6Q 8E6R 8E6S 8E6T 8E6U 8E6V
Enriched GO Terms of Interacting Partners?		Calcium Ion Transport Calcium Channel Activity Store-operated Calcium Channel Activity Calcium Ion Transmembrane Transport Inositol 1,4,5 Trisphosphate Binding Metal Ion Transport Monoatomic Cation Transport Monoatomic Ion Channel Activity Monoatomic Ion Transport Cellular Response To Hydrogen Peroxide Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Intracellularly Gated Calcium Channel Activity Inorganic Ion Transmembrane Transport Phospholipase Activator Activity Response To Hydrogen Peroxide Manganese Ion Transport Monoatomic Ion Transmembrane Transport Cellular Response To Reactive Oxygen Species Cation Channel Complex Response To Calcium Ion Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Stimulatory C-type Lectin Receptor Signaling Pathway Phospholipase Binding Cellular Response To Lectin Response To Reactive Oxygen Species Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Calcium-mediated Signaling Ephrin Receptor Binding Negative Regulation Of Inflammatory Response To Antigenic Stimulus Transmembrane Transport Membrane Raft Plasma Membrane Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Oxidative Stress Fc-gamma Receptor Signaling Pathway Calcium Ion Homeostasis Calcium Ion Import Regulation Of Calcium Ion Transport Leukocyte Migration Non-membrane Spanning Protein Tyrosine Kinase Activity Homeostatic Process Membrane T Cell Costimulation Ephrin Receptor Signaling Pathway Cellular Response To Chemical Stress Perinuclear Region Of Cytoplasm Peptidyl-tyrosine Phosphorylation	Inositol 1,4,5 Trisphosphate Binding Calcium Channel Activity Inositol 1,3,4,5 Tetrakisphosphate Binding Positive Regulation Of Cytosolic Calcium Ion Concentration Sensory Perception Of Umami Taste Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity Sensory Perception Of Sweet Taste Monoatomic Ion Channel Activity Calcium Ion Homeostasis Sensory Perception Of Bitter Taste Calcium Ion Transport Calcium Ion Transmembrane Transport Inositol Hexakisphosphate Binding Intracellularly Gated Calcium Channel Activity Platelet Dense Tubular Network Membrane Negative Regulation Of Dendrite Morphogenesis Slit Diaphragm Store-operated Calcium Channel Activity Neuronal Cell Body TRAPPII Protein Complex Inorganic Ion Homeostasis TRAPP Complex Actinin Binding Cytoplasmic Side Of Endoplasmic Reticulum Membrane Early Endosome To Golgi Transport Cation Channel Complex Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Axonemal A Tubule Inner Sheath Sensory Perception Of Taste Monoatomic Cation Transmembrane Transport Metal Ion Transport Inorganic Cation Transmembrane Transport Nuclear Outer Membrane Calcium Ion Binding Intra-Golgi Vesicle-mediated Transport Vesicle Tethering Monoatomic Cation Channel Activity Positive Regulation Of Ion Transmembrane Transporter Activity Clathrin Binding Axonemal Microtubule Cerebral Cortex Cell Migration Vesicle Coating
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