C4A and CST3

Number of citations of the paper that reports this interaction (PubMedID 2304899)
24

Data Source:
HPRD (in vitro)

		C4A	CST3
Description		complement C4A (Chido/Rodgers blood group)	cystatin C
Image
GO Annotations	Cellular Component	Extracellular Region Classical-complement-pathway C3/C5 Convertase Complex Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Cell Surface Axon Dendrite Cell Projection Neuronal Cell Body Synapse Extracellular Exosome Blood Microparticle Symbiont Cell Surface	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Plasma Membrane Vesicle Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Complement Binding Complement Component C1q Complex Binding Antigen Binding Endopeptidase Inhibitor Activity Protein Binding	Amyloid-beta Binding Protease Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity Identical Protein Binding
	Biological Process	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Immune System Process Inflammatory Response Complement Activation Complement Activation, Classical Pathway Opsonization Killing Of Cells Of Another Organism Innate Immune Response Protein Maturation Complement Activation, GZMK Pathway Positive Regulation Of Apoptotic Cell Clearance	Defense Response Immune Response Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Extracellular Matrix Disassembly Regulation Of Tissue Remodeling Negative Regulation Of Proteolysis Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling Supramolecular Fiber Organization
Pathways		Initial triggering of complement Activation of C3 and C5 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Regulation of Complement cascade	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation Amyloid fiber formation
Drugs		Human immunoglobulin G
Diseases		Systemic lupus erythematosus Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency	Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Feeling worry ( 29500382) Inflammatory bowel disease ( 28067908) Neurociticism ( 29500382) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Prostate cancer ( 23535732) Ulcerative colitis ( 28067908)	Chronic kidney disease ( 20383146) Cystatin C levels ( 17903292) Glomerular filtration rate (cystatin C) ( 28452372) Plasma cystastin c levels in acute coronary syndrome ( 24952865)
Interacting Genes		8 interacting genes: APC APOA2 C3AR1 C5AR2 CR1 CST3 HSP90AA1 MASP2	10 interacting genes: ATXN1 C4A CSTB CTSB CTSD CTSL CTSS PDZD2 POLE3 RNF115
Entrez ID		720	1471
HPRD ID		00401	05056
Ensembl ID		ENSG00000244731	ENSG00000101439
Uniprot IDs		P0C0L4	A0A0K0K1J1 P01034
PDB IDs		1HZF 5JPM 5JPN 5JTW 6YSQ 7B2M 7B2P 7B2Q	1G96 1R4C 1TIJ 3GAX 3NX0 3PS8 3QRD 3S67 3SVA 6ROA 6RPV
Enriched GO Terms of Interacting Partners?		Complement Receptor Activity Complement Receptor Mediated Signaling Pathway Complement Component C4b Binding Complement Component C5a Receptor Activity Activation Of Immune Response Complement Component C5a Signaling Pathway Positive Regulation Of Immune Response Regulation Of Cytokine Production Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Multicellular Organismal Process Positive Regulation Of Immune System Process Immune System Process Response To Stress Regulation Of Neutrophil Chemotaxis Complement Activation, Classical Pathway Defense Response Regulation Of Neutrophil Migration Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Granulocyte Chemotaxis Complement Activation Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Cytokine Production Immune Response-activating Signaling Pathway Complement Component C3a Receptor Activity Complement Component C3b Receptor Activity Immune Complex Clearance By Erythrocytes Complement Component C4b Receptor Activity Negative Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Elastin Catabolic Process CTP Binding DATP Binding Regulation Of Protein Catabolic Process Regulation Of Interleukin-8 Production Immune Response-regulating Signaling Pathway Positive Regulation Of Activation Of Membrane Attack Complex Negative Regulation Of Plasma Cell Differentiation Negative Regulation Of Blood Vessel Remodeling Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Extracellular Exosome Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cytokine Production Peptidyl-methionine Modification High-density Lipoprotein Particle Receptor Binding Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cholesterol Import	Endolysosome Lumen Cysteine-type Endopeptidase Activity Proteoglycan Binding Cellular Response To Thyroid Hormone Stimulus Response To Thyroid Hormone Ficolin-1-rich Granule Lumen Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Collagen Catabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Extracellular Matrix Antigen Processing And Presentation Of Exogenous Antigen Tertiary Granule Lumen Collagen Metabolic Process Collagen Binding Antigen Processing And Presentation Of Peptide Antigen Lysosomal Lumen Antigen Processing And Presentation Extracellular Region Cysteine-type Peptidase Activity Extracellular Space Peptidase Activity Lysosome Fibronectin Binding Proteolysis Endopeptidase Inhibitor Activity Proteolysis Involved In Protein Catabolic Process Serpin Family Protein Binding Fusion Of Virus Membrane With Host Endosome Membrane Protein Maturation Cellular Response To Hormone Stimulus Macromolecule Metabolic Process Adult Locomotory Behavior Endopeptidase Activity Aspartic-type Peptidase Activity Enkephalin Processing Classical-complement-pathway C3/C5 Convertase Complex Activation Of Immune Response Melanosome Macrophage Apoptotic Process Elastin Catabolic Process Fusion Of Virus Membrane With Host Plasma Membrane Basement Membrane Disassembly Symbiont Entry Into Host Cell Peptidase Inhibitor Complex Insulin Catabolic Process Insulin Receptor Recycling Chromaffin Granule POZ Domain Binding
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