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TRAF1 and EHHADH
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid)
TRAF1
EHHADH
Description
TNF receptor associated factor 1
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Peroxisome
Peroxisomal Matrix
Cytosol
Molecular Function
Tumor Necrosis Factor Receptor Binding
Protein Binding
Zinc Ion Binding
Ubiquitin Protein Ligase Binding
Thioesterase Binding
Signaling Adaptor Activity
Identical Protein Binding
Catalytic Activity
(3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity
Delta(3)-delta(2)-enoyl-CoA Isomerase Activity
Enoyl-CoA Hydratase Activity
Protein Binding
Oxidoreductase Activity
Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity
Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor
Lyase Activity
Isomerase Activity
Intramolecular Oxidoreductase Activity, Transposing C=C Bonds
3-hydroxyacyl-CoA Dehydratase Activity
Enzyme Binding
NAD+ Binding
Biological Process
Apoptotic Process
Signal Transduction
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein-containing Complex Assembly
Regulation Of Extrinsic Apoptotic Signaling Pathway
Lipid Metabolic Process
Fatty Acid Metabolic Process
Fatty Acid Beta-oxidation
Unsaturated Fatty Acid Biosynthetic Process
Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase
Alpha-linolenic Acid Metabolic Process
Long-chain Fatty Acid Biosynthetic Process
Fatty Acid Derivative Biosynthetic Process
Pathways
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
Beta-oxidation of very long chain fatty acids
Peroxisomal protein import
Peroxisomal protein import
Drugs
NADH
Diseases
GWAS
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Asthma (
32296059
)
Celiac disease or Rheumatoid arthritis (
21383967
)
Eosinophil percentage of white cells (
32888494
)
Lymphocyte count (
27863252
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Pulse pressure (
30578418
)
Refractive error (
32231278
)
Rheumatoid arthritis (
24390342
24782177
23143596
30891314
19503088
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
White blood cell count (
32888494
)
Cognitive performance (
19734545
)
Major depressive disorder (
21042317
27519822
)
Interacting Genes
249 interacting genes:
A1CF
ABHD17A
ACTN3
AIRIM
AKAP17A
AQP1
ARID5A
ARNT2
ARSJ
BARD1
BCAS2
BCL6
BEX2
BEX3
BIRC2
BIRC3
C1orf216
CARHSP1
CASP10
CASP3
CASP6
CASP8
CATSPERT
CCDC116
CCDC120
CCDC146
CCDC185
CCDC187
CCDC198
CCHCR1
CD40
CDC20
CDCA3
CDK18
CDKN1A
CDKN2B
CFLAR
CHCHD3
CNTRL
COX5B
CRACR2A
CRY2
CRYGA
CYB5R2
DEPTOR
DGCR6
DMRT3
DOK3
DUSP13B
DUSP21
DUSP4
EBF2
EDAR
EHHADH
ENG
ENKD1
EWSR1
FAM161A
FAM161B
FAM86C1P
FBF1
FBXL18
FOSL2
GADD45GIP1
GATA1
GATA2
GATAD2B
GCA
GCM2
GEM
GFI1B
GIT2
GLIS3
GLRX3
GMCL2
GNG5
GOLGA2
GORASP2
GRAP2
HAUS1
HELT
HEY2
HGS
HIVEP3
HMG20B
HNRNPM
HOXA1
HOXB5
HOXC8
HOXD12
IKBKB
JOSD1
KANK2
KIAA1217
KIF1A
KLHL38
KPNA2
KRT3
KRT75
LCOR
LIN37
LMNTD2
LNX1
LNX2
LRRN1
LTBR
MACIR
MAP3K14
MAP6
MAPRE2
MATR3
METTL17
MORN3
MOS
MSGN1
MYEF2
MYOZ1
NEBL
NOL4L-DT
NTAQ1
NUFIP2
NUP58
OLIG3
PATZ1
PBX3
PDE4D
PHF21A
PIN1
PITX1
PITX2
PKN1
PLAC8
PLEKHN1
POM121L4P
POP5
PPP1R13B
PRDM7
PRKAB2
PSMA1
PSMB1
QRICH1
RASAL2
RASSF5
RBCK1
RBM41
RBM45
RCOR3
RIIAD1
RIPK1
RIPK2
RIPOR3
RIPPLY1
RNF31
RTP5
SAMD11
SAXO4
SCAMP1
SCNM1
SDCBP2
SH3GLB2
SHARPIN
SHC3
SHFL
SIK3
SLC25A48
SLC25A6
SNRNP25
SNW1
SOHLH1
SPATA46
SPG21
SPMIP2
SPOP
SPTAN1
SRC
SSC5D
STK3
SUMO2
SYCE1
TANK
TBC1D16
TBC1D8
TBX18
TCEA2
TCF7L2
TCL1A
TEAD4
TFAP2D
TFAP4
TFPT
THAP7
TICAM1
TIFA
TLE5
TNFAIP3
TNFRSF11A
TNFRSF12A
TNFRSF14
TNFRSF17
TNFRSF18
TNFRSF19
TNFRSF1A
TNFRSF1B
TNFRSF4
TNFRSF8
TNFRSF9
TNFSF9
TRADD
TRAF2
TRAF3IP2
TRAF6
TRAIP
TRIM23
TRIM37
TRIM42
TRPV6
TSHZ2
TSSC4
USP2
USP7
UTP14C
VEZF1
WAC
ZBTB1
ZBTB16
ZC2HC1C
ZFYVE21
ZFYVE26
ZIC1
ZNF124
ZNF20
ZNF23
ZNF250
ZNF417
ZNF440
ZNF490
ZNF502
ZNF512B
ZNF564
ZNF572
ZNF581
ZNF587
ZNF627
ZNF648
ZNF662
ZNF669
ZNF688
ZNF697
ZNF844
98 interacting genes:
AARS2
ACTB
ACTG1
ADARB1
ANKRD36B
ARMC12
ARMCX3
BHLHE40
BOLL
CAT
CBS
CCDC102B
CCDC13
CDR2L
CEP83
CISD2
CLDN18
CLDN5
CLK2
CMTM6
COQ9
CYB561
CYB561A3
DAAM2
DERL3
DES
DRC4
EMP1
ERGIC1
FGF14
FUNDC1
GMCL1
GRIPAP1
HID1
HIP1
HSD17B11
HTATIP2
JAGN1
KCTD9
KRTAP10-7
KRTAP4-11
LCN2
LEPROTL1
LYPD5
LZTFL1
LZTS2
MAB21L3
MID1
MTUS2
NACC1
NECAB2
OPRM1
ORMDL1
PAQR8
PICK1
PNMA1
PNMA5
PPP1R12C
PRKRA
PSTPIP1
PTGES
REL
RNF4
RPRM
RUSF1
SCARA5
SCP2
SDR16C5
SGCB
SLC14A2
SLC39A2
SMIM5
SMN1
SMN2
SSNA1
SSX2IP
SYNGR3
TMEM121
TMEM17
TMEM31
TMEM35A
TNIP1
TPP2
TRAF1
TRIM21
TRIM23
TRIM27
TRIM41
TRIM5
TRIM54
TRIM55
TRIM63
VAC14
ZBTB10
ZBTB26
ZBTB8A
ZBTB9
ZCCHC17
Entrez ID
7185
1962
HPRD ID
03418
06125
Ensembl ID
ENSG00000056558
ENSG00000113790
Uniprot IDs
Q13077
Q08426
PDB IDs
3M0D
5E1T
5H10
Enriched GO Terms of Interacting Partners
?
Tumor Necrosis Factor-mediated Signaling Pathway
Protein Binding
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Tumor Necrosis Factor Receptor Activity
Zinc Ion Binding
Regulation Of Metabolic Process
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Non-canonical NF-kappaB Signal Transduction
Nucleus
DNA Binding
Ripoptosome
CD40 Receptor Complex
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Regulation Of Necroptotic Process
Death-inducing Signaling Complex
Apoptotic Process
Regulation Of Programmed Cell Death
Tumor Necrosis Factor Receptor Superfamily Complex
Regulation Of Programmed Necrotic Cell Death
Programmed Cell Death
Cell Death
CD40 Signaling Pathway
Positive Regulation Of Programmed Cell Death
Cytokine-mediated Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Necroptotic Process
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Programmed Necrotic Cell Death
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of RNA Metabolic Process
Identical Protein Binding
Apoptotic Signaling Pathway
Sequence-specific Double-stranded DNA Binding
Protein Linear Polyubiquitination
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Canonical NF-kappaB Signal Transduction
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Death Receptor Binding
Identical Protein Binding
Protein Binding
Ubiquitin Protein Ligase Activity
Negative Regulation Of Protein Localization
Innate Immune Response
Protein K63-linked Ubiquitination
Suppression Of Viral Release By Host
Regulation Of Transepithelial Transport
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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