TPTE and EPHA1

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		TPTE	EPHA1
Description		transmembrane phosphatase with tensin homology	EPH receptor A1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Membrane	Plasma Membrane Membrane Receptor Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Monoatomic Ion Channel Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Hydrolase Activity Phosphatase Activity	Nucleotide Binding Fibronectin Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding
	Biological Process	Protein Dephosphorylation Phosphate-containing Compound Metabolic Process Monoatomic Ion Transport Signal Transduction Monoatomic Ion Transmembrane Transport Transmembrane Transport	Angiogenesis Positive Regulation Of Cell-matrix Adhesion Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Angiogenesis Ephrin Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly
Pathways		Synthesis of PIPs at the Golgi membrane	EPH-Ephrin signaling EPH-Ephrin signaling POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs			Fostamatinib
Diseases
GWAS		Celiac disease ( 23936387)	Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 21460841 24162737 30617256) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256 33589840) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Blood protein levels ( 30072576) Family history of Alzheimer's disease ( 30617256) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)
Interacting Genes		12 interacting genes: ADRB2 EPHA1 EPHA2 EPHA3 ERBB3 MEOX2 NTRK1 PDGFRB PTK7 ROR2 TLN1 TUBB3	12 interacting genes: CTDSP2 DAPK1 DUSP14 EFNA1 ERBB2 GJB1 MAP3K1 MTMR14 PTPN11 SMURF1 SMURF2 TPTE
Entrez ID		7179	2041
HPRD ID		05064	01554
Ensembl ID		ENSG00000274391	ENSG00000146904
Uniprot IDs		P56180	P21709
PDB IDs			2K1K 2K1L 3HIL 3KKA
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Receptor Complex Protein Kinase Activity Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Signaling Pathway Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Ephrin Receptor Activity ATP Binding Signal Transduction Positive Regulation Of Cellular Component Organization Nucleotide Binding Peptidyl-tyrosine Phosphorylation GPI-linked Ephrin Receptor Activity Neuron Projection Guidance Axon Guidance Regulation Of Cell Junction Assembly Angiogenesis Transmembrane-ephrin Receptor Activity Regulation Of Cellular Component Organization Regulation Of MAPK Cascade Transferase Activity Plasma Membrane Neuron Differentiation Tissue Development Regulation Of Cell-matrix Adhesion Regulation Of GTPase Activity Axon Regulation Of Cell Adhesion Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Neuron Projection Development Focal Adhesion Cell Adhesion Positive Regulation Of MAPK Cascade Cranial Nerve Development Neuron Projection Development Regulation Of Cell Migration Response To Wounding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Motility Growth Factor Binding Positive Regulation Of Cell Migration Regulation Of Catalytic Activity Regulation Of Cell-substrate Adhesion Nerve Development Regulation Of Locomotion Positive Regulation Of Cell Motility Cellular Response To Amyloid-beta	Protein Modification Process Phosphoprotein Phosphatase Activity Phosphate-containing Compound Metabolic Process Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Dephosphorylation Cell Surface Receptor Signaling Pathway Protein Metabolic Process Wnt Signaling Pathway, Planar Cell Polarity Pathway DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Ephrin Receptor Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Engulfment Of Target By Autophagosome SMAD Binding Non-canonical Wnt Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Receptor Tyrosine Kinase Binding Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Negative Regulation Of T Cell Proliferation ERBB3:ERBB2 Complex ERBB Signaling Pathway Cellular Response To Mechanical Stimulus Intestinal Epithelial Cell Migration Phosphatase Activity Protein Phosphorylation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Phosphorylation Notochord Formation RNA Polymerase I Core Binding Cerebellar Cortex Formation Negative Regulation Of Leukocyte Proliferation Signal Transduction Regulation Of NMDA Receptor Activity Positive Regulation Of MAPK Cascade Endocardial Cushion To Mesenchymal Transition Negative Regulation Of Dendritic Spine Morphogenesis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Immature T Cell Proliferation In Thymus Glial Cell Differentiation ErbB-3 Class Receptor Binding Immature T Cell Proliferation In Thymus
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