TNXB and CEACAM6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TNXB	CEACAM6
Description		tenascin XB	CEA cell adhesion molecule 6
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Exosome Tenascin Complex	Extracellular Space Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Azurophil Granule Membrane Side Of Membrane
	Molecular Function	Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Heparin Binding Collagen Fibril Binding	Protein Binding Identical Protein Binding Protein Heterodimerization Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Triglyceride Metabolic Process Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Actin Cytoskeleton Organization Regulation Of Cell Adhesion Extracellular Matrix Organization Collagen Fibril Organization Regulation Of Cell Migration Neuron Projection Development Collagen Metabolic Process Regulation Of Cell Differentiation Regulation Of JNK Cascade Elastic Fiber Assembly Cell-cell Adhesion Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Collagen Fibril Organization Positive Regulation Of Cell Fate Determination	Apoptotic Process Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Negative Regulation Of Anoikis
Pathways		ECM proteoglycans	Fibronectin matrix formation Cell surface interactions at the vascular wall Neutrophil degranulation
Drugs
Diseases		Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS		A body shape index ( 34021172) Age-related macular degeneration ( 22694956) Alzheimer's disease ( 30636644) Asthma ( 31619474) Atopic dermatitis ( 23886662) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Coronary artery disease ( 32469254) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Eosinophil count ( 27863252) Femur bone mineral density x serum urate levels interaction ( 34046847) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) HIV-1 control ( 20041166) Inflammatory bowel disease ( 28067908) Intraocular pressure ( 30054594 29617998) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Mean corpuscular volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Neutrophil count ( 32888494) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Platelet distribution width ( 32888494) Prostate cancer ( 23535732) Refractive error ( 32231278) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Schizophrenia ( 30285260) Shingles ( 28928442) Squamous cell lung carcinoma ( 28604730) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 26316170 26502338 28714469 21408207) Systolic blood pressure ( 28739976) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494 27863252)	Serum carcinoembryonic antigen levels ( 31666285)
Interacting Genes		7 interacting genes: BANP CEACAM6 POU6F2 TGM7 TNF VEGFA VEGFB	32 interacting genes: APP ASPG CARTPT CEACAM1 CEACAM5 CEACAM7 CEACAM8 CIB1 CSTF2 EXOC3L1 FOXH1 GCM2 GPANK1 HGS HPCAL4 KANK2 MSS51 MYOZ1 PITX1 POM121 QRICH1 RHOXF2 SHC3 SMARCD1 TLX3 TNXB UBQLN2 VENTX VEZF1 WWOX ZMYND19 ZNF76
Entrez ID		7148	4680
HPRD ID		02993	01233
Ensembl ID		ENSG00000168477	ENSG00000086548
Uniprot IDs		A0A3B3ISX9 O95680 O95681 P22105 Q6IPK3 Q9Y464	P40199
PDB IDs		2CUH 2CUI 2CUM	4WHC 4WTZ 4Y8A 4YIQ
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Binding Vascular Endothelial Growth Factor Receptor 1 Binding Positive Regulation Of Mast Cell Chemotaxis Regulation Of Mast Cell Chemotaxis Positive Regulation Of Heterotypic Cell-cell Adhesion Regulation Of Vascular Wound Healing Receptor Ligand Activity Regulation Of Endothelial Cell Proliferation Positive Regulation Of Leukocyte Migration Regulation Of Establishment Of Endothelial Barrier Vascular Endothelial Growth Factor Signaling Pathway Induction Of Positive Chemotaxis Positive Regulation Of Vascular Permeability Positive Regulation Of Cell Motility Positive Regulation Of Cell Migration Positive Regulation Of Locomotion Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Positive Chemotaxis Negative Regulation Of MiRNA Transcription Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Leukocyte Migration Chemoattractant Activity Positive Regulation Of Protein Phosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Sprouting Angiogenesis Positive Regulation Of Phosphorylation Regulation Of Endothelial Cell Differentiation Vascular Process In Circulatory System Positive Regulation Of DNA Biosynthetic Process Positive Chemotaxis Regulation Of ERK1 And ERK2 Cascade Regulation Of Vascular Permeability Identical Protein Binding Negative Regulation Of Apoptotic Process Vasodilation Positive Regulation Of Phosphate Metabolic Process Regulation Of Morphogenesis Of A Branching Structure Response To Decreased Oxygen Levels Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Hypoxia Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Fat Cell Differentiation Regulation Of Angiogenesis Circulatory System Process Negative Regulation Of Programmed Cell Death Regulation Of Vasculature Development Positive Regulation Of Cell Population Proliferation Response To Oxygen Levels Positive Regulation Of Cell-matrix Adhesion	Response To Nerve Growth Factor Cellular Response To Nerve Growth Factor Stimulus Central Nervous System Development Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Developmental Process
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