TNR and BCAN

Number of citations of the paper that reports this interaction (PubMedID 9294172)
28

Data Source:
HPRD (in vitro)

		TNR	BCAN
Description		tenascin R	brevican
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface Extracellular Matrix Membrane Raft Perineuronal Net Tenascin Complex Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Extracellular Region Extracellular Space Golgi Lumen Membrane Extracellular Matrix Lysosomal Lumen Synapse Perineuronal Net Side Of Membrane Glutamatergic Synapse
	Molecular Function		Protein Binding Hyaluronic Acid Binding Carbohydrate Binding
	Biological Process	Cell Adhesion Neuron Cell-cell Adhesion Nervous System Development Axon Guidance Associative Learning Negative Regulation Of Neuron Projection Development Telencephalon Cell Migration Negative Regulation Of Cell-cell Adhesion Regulation Of Cell Adhesion Extracellular Matrix Organization Regulation Of Cell Migration Negative Regulation Of Axon Extension Synaptic Transmission, Glutamatergic Locomotory Exploration Behavior Regulation Of Cell Differentiation Axon Extension Axon Extension Involved In Regeneration Negative Regulation Of Axon Extension Involved In Regeneration Modulation Of Chemical Synaptic Transmission Negative Regulation Of Synaptic Transmission Synapse Organization Neuromuscular Process Controlling Balance Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Transmission Of Nerve Impulse Long-term Synaptic Potentiation Neuroblast Migration	Skeletal System Development Cell Adhesion Central Nervous System Development Hippocampus Development Synapse Maturation
Pathways		ECM proteoglycans	Degradation of the extracellular matrix Glycosaminoglycan-protein linkage region biosynthesis CS-GAG biosynthesis DS-GAG biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Attention deficit hyperactivity disorder ( 30563984) Body mass index ( 26426971) Corneal astigmatism ( 29422769) Disease progression to choroidal neovascularization form in age-related macular degeneration ( 29346644) Liver fibrosis in non-alcoholic fatty liver disease ( 31311600) Sleep (1/2-day periodicity) ( 33075057) Telomere length ( 30185882) Testosterone levels x fluid intelligence interaction ( 33407712) Tonometry ( 17903302)	Blood protein levels ( 30072576)
Interacting Genes		18 interacting genes: ACAN BCAN CCDC146 CNTN1 LGALS14 MAGEB4 NCAN NCK2 NFASC NTAQ1 POLR3C PSMA1 PTPRZ1 QSOX1 RUNX1 SIGLEC1 TRIM54 VCAN	10 interacting genes: ADAMTS4 FBLN2 MMP1 MMP10 MMP13 MMP2 MMP3 MMP7 MMP8 TNR
Entrez ID		7143	63827
HPRD ID		03589	02644
Ensembl ID		ENSG00000116147	ENSG00000132692
Uniprot IDs		A1L306 Q92752	Q96GW7
PDB IDs		8FN9 8FNA
Enriched GO Terms of Interacting Partners?		Perineuronal Net Carbohydrate Binding Hyaluronic Acid Binding Central Nervous System Development Lysosomal Lumen Golgi Lumen Cell Adhesion Synapse Skeletal System Development Extracellular Matrix Structural Constituent Conferring Compression Resistance System Development Cell-cell Adhesion Mediator Activity Extracellular Matrix Clathrin-dependent Endocytosis Of Virus By Host Cell Protein-N-terminal Glutamine Amidohydrolase Activity	Extracellular Matrix Disassembly Collagen Catabolic Process Metalloendopeptidase Activity Extracellular Matrix Extracellular Structure Organization Extracellular Matrix Organization Metallopeptidase Activity Collagen Metabolic Process Endopeptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Extracellular Region Cellular Response To UV-A Proteolysis Response To UV-A Extracellular Space Hydrolase Activity Catabolic Process Zinc Ion Binding Response To Amyloid-beta Cellular Response To UV Protein Metabolic Process Cellular Response To Light Stimulus Response To UV Cellular Response To Radiation Metal Ion Binding Endodermal Cell Differentiation Regulation Of Neuroinflammatory Response Antibacterial Peptide Secretion Response To Light Stimulus Cellular Response To Amino Acid Stimulus Macromolecule Metabolic Process Negative Regulation Of Axon Extension Involved In Regeneration Response To Radiation Regulation Of Cell Migration Cellular Response To Reactive Oxygen Species Antibacterial Peptide Biosynthetic Process Axon Extension Involved In Regeneration Regulation Of Cell Motility Response To Amino Acid Cellular Response To Lipid Regulation Of Locomotion Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Tenascin Complex Neuroblast Migration Ossification Intramembranous Ossification Blood Vessel Maturation Peripheral Nervous System Axon Regeneration Response To Reactive Oxygen Species
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