CLEC3B and HGF

Number of citations of the paper that reports this interaction (PubMedID 12694198)
0

Data Source:
HPRD (in vitro)

		CLEC3B	HGF
Description		C-type lectin domain family 3 member B	hepatocyte growth factor
Image
GO Annotations	Cellular Component	Granular Component Extracellular Region Extracellular Space Cytoplasm Extracellular Matrix Platelet Dense Granule Lumen Extracellular Exosome	Extracellular Region Extracellular Space Membrane Platelet Alpha Granule Lumen
	Molecular Function	Calcium Ion Binding Heparin Binding Carbohydrate Binding Kringle Domain Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Growth Factor Activity Chemoattractant Activity Identical Protein Binding
	Biological Process	Ossification Positive Regulation Of Plasminogen Activation Bone Mineralization	Mitotic Cell Cycle Cell Morphogenesis Epithelial To Mesenchymal Transition Liver Development Proteolysis Signal Transduction Negative Regulation Of Autophagy Skeletal Muscle Cell Proliferation Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Cell Migration Negative Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-10 Production Cellular Response To Hepatocyte Growth Factor Stimulus Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Hepatocyte Growth Factor Receptor Signaling Pathway Animal Organ Development Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Positive Chemotaxis Regulation Of Multicellular Organismal Process Myoblast Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Chemotaxis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of P38MAPK Cascade Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of DNA Biosynthetic Process
Pathways		Platelet degranulation	Platelet degranulation PIP3 activates AKT signaling Interleukin-7 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling MET Receptor Activation Negative regulation of MET activity PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates RAS signaling MET activates PI3K/AKT signaling MET activates PTPN11 MET activates PTK2 signaling MET interacts with TNS proteins MET activates RAP1 and RAC1 MET receptor recycling MET activates STAT3 Drug-mediated inhibition of MET activation
Drugs		Tenecteplase Lanoteplase Copper	Valproic acid Heparin O2-Sulfo-Glucuronic Acid N,O6-Disulfo-Glucosamine ABT-510 Foretinib
Diseases
GWAS		Acne (severe) ( 24927181) Alzheimer's disease ( 33654092) Blood protein levels ( 30072576)	Blood protein levels ( 30072576) Endothelial growth factor levels ( 25552591) Gestational age at birth (maternal effect) ( 28598419) Gout ( 22179738) Gout (normal type) ( 32238385) Hepatocyte growth factor levels ( 25998175 27989323) Intraocular pressure ( 29235454 29785010) Rosacea symptom severity ( 29771307) Spontaneous preterm birth (maternal effect) ( 28598419) Transverse temporal cortex volume ( 31530798) Tuberculosis ( 29036319)
Interacting Genes		13 interacting genes: ANXA7 APP CDKN1A GADD45A GORASP1 GSK3B HGF PLAT PLG RPS6KA6 RPS6KB1 SH3GL2 TK1	36 interacting genes: ADAMTSL4 ARNT BRCA1 CCND2 CDK4 CDK6 CDKN2A CDKN2B CLEC3B EPHA2 ERBB2 F11 FGFR4 FN1 GLIS2 HGFAC HPN KLKB1 LATS2 LCN2 MAP2K5 MAP2K6 MDM4 MEOX2 MET NF2 PDGFRA PLAU RAF1 SDC1 SDC2 ST14 STK11 TEAD2 VTN YWHAG
Entrez ID		7123	3082
HPRD ID		01759	00799
Ensembl ID		ENSG00000163815	ENSG00000019991
Uniprot IDs		E9PHK0 P05452	P14210
PDB IDs		1HTN 1RJH 1TN3 3L9J	1BHT 1GMN 1GMO 1GP9 1NK1 1SHY 1SI5 2HGF 2QJ2 3HMS 3HMT 3HN4 3MKP 3SP8 4D3C 4K3J 4O3T 4O3U 5COE 5CP9 5CS1 5CS3 5CS5 5CS9 5CSQ 5CT1 5CT2 5CT3 7MO7 7MO8 7MO9 7MOA 7MOB 7OCL 7OCM
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Multicellular Organismal Process Negative Regulation Of TORC2 Signaling Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Trans-synaptic Signaling By BDNF Negative Regulation Of Gene Expression Regulation Of Extrinsic Apoptotic Signaling Pathway Platelet Alpha Granule Lumen Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Reactive Oxygen Species Metabolic Process Modulation Of Chemical Synaptic Transmission Negative Regulation Of Metabolic Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle TOR Signaling Negative Regulation Of Fibrinolysis Trans-synaptic Signaling, Modulating Synaptic Transmission Glutamatergic Synapse Cellular Response To Growth Factor Stimulus Regulation Of TORC2 Signaling Regulation Of Multicellular Organismal Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway TORC2 Signaling Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Biosynthetic Process Apolipoprotein Binding Response To Growth Factor Regulation Of Fibrinolysis Regulation Of MAPK Cascade Fibrinolysis Negative Regulation Of Macromolecule Metabolic Process Developmental Growth Signaling Receptor Binding Central Nervous System Development Regulation Of Reactive Oxygen Species Metabolic Process Molecular Function Activator Activity Protein Serine/threonine Kinase Binding Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Mitotic Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage Serine-type Endopeptidase Activity Positive Regulation Of Blood Coagulation Negative Regulation Of Catalytic Activity Cell Cycle Phase Transition Positive Regulation Of Coagulation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Intracellular Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway	Protein Kinase Activity Negative Regulation Of Multicellular Organismal Process Kinase Activity Regulation Of Cell Population Proliferation Protein Tyrosine Kinase Activity Regulation Of Protein Metabolic Process Signal Transduction Cellular Developmental Process Developmental Process Cell Differentiation Regulation Of Fibrinolysis Animal Organ Development Negative Regulation Of Blood Coagulation Regulation Of Epithelial Cell Proliferation Negative Regulation Of Hemostasis Transmembrane Receptor Protein Tyrosine Kinase Activity Negative Regulation Of Coagulation Regulation Of Multicellular Organismal Process Serine-type Peptidase Activity Regulation Of Signal Transduction Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Cellular Component Organization Positive Regulation Of Protein Metabolic Process Serine-type Endopeptidase Activity Positive Regulation Of Macromolecule Biosynthetic Process Cell Surface Receptor Signaling Pathway Zymogen Activation Positive Regulation Of Biosynthetic Process Plasminogen Activation Positive Regulation Of Signal Transduction Regulation Of Developmental Process Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Macromolecule Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Maturation Positive Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Cell Adhesion Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Metabolic Process Regulation Of Cell Motility Protein Metabolic Process Positive Regulation Of Fibroblast Proliferation Regulation Of Plasminogen Activation Regulation Of Cell-substrate Adhesion Enzyme-linked Receptor Protein Signaling Pathway
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