CLDN5 and EFNA5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLDN5	EFNA5
Description		claudin 5	ephrin A5
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Cell Junction Cortical Actin Cytoskeleton Paranode Region Of Axon Schmidt-Lanterman Incisure Tight Junction Anchoring Junction	Basement Membrane Plasma Membrane Caveola Adherens Junction External Side Of Plasma Membrane Membrane Cell Periphery Side Of Membrane GABA-ergic Synapse
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding	Neurotrophin TRKA Receptor Binding Neurotrophin TRKB Receptor Binding Neurotrophin TRKC Receptor Binding Protein Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Chemorepellent Activity Ephrin Receptor Binding
	Biological Process	Outflow Tract Morphogenesis Cell-cell Junction Assembly Cell Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Learning Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Negative Regulation Of Angiogenesis Negative Regulation Of Cell Migration Maintenance Of Blood-brain Barrier Myelination Negative Regulation Of Vascular Permeability Response To Ethanol Roof Of Mouth Development Face Morphogenesis Bicellular Tight Junction Assembly Tight Junction Assembly Positive Regulation Of Establishment Of Endothelial Barrier Positive Regulation Of Bicellular Tight Junction Assembly Establishment Of Blood-retinal Barrier	Apoptotic Process Nervous System Development Axon Guidance Regulation Of Cell-cell Adhesion Regulation Of Cell Morphogenesis Cell Differentiation Retinal Ganglion Cell Axon Guidance Regulation Of Actin Cytoskeleton Organization Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Collateral Sprouting Positive Regulation Of Collateral Sprouting Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Chemotaxis Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Synapse Assembly Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Follicle-stimulating Hormone Stimulus Synaptic Membrane Adhesion Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Cellular Response To Forskolin
Pathways		Tight junction interactions RUNX1 regulates expression of components of tight junctions	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs
Diseases
GWAS			Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Alanine aminotransferase levels ( 34315874 33547301) Alzheimer's disease biomarkers ( 23419831) Aspartate aminotransferase levels ( 34315874) Atrial fibrillation ( 29892015) Body mass index ( 26426971) Chronotype ( 30696823) Cocaine dependence ( 31212010) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Daytime nap ( 33568662) Dentures ( 31235808) Hippocampal atrophy ( 19668339) Household income (MTAG) ( 31844048) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Longitudinal cocaine use ( 31591132) Medial orbital frontal cortex volume ( 31530798) Metabolite levels ( 23823483) Moderate-to-late spontaneous preterm birth ( 31194736) Neonatal cytokine/chemokine levels (maternal genetic effect) ( 30134952) Non-del(5q) myelodysplastic syndromes ( 31738830) Nose morphology ( 29921221) Number of children ever born ( 27798627) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Sedentary behaviour duration ( 30531941) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		40 interacting genes: AQP1 BTNL8 CCDC167 CLDN3 CLRN2 CNPY3 CORIN CTRL CXCL9 CYB561A3 EFNA5 EHHADH ERG28 ERMP1 FXYD6-FXYD2 GYPA LAT LHFPL5 MIP MPDZ PLP2 PLPPR2 PMP22 RPRM SFTPC SGCG SLC35B4 SMIM3 TECR TF TJP1 TMEM128 TMEM140 TMEM14C TMEM182 TMEM190 TMEM222 TSPAN2 VAMP5 YIPF1	38 interacting genes: ACKR2 AQP2 AQP6 BEST2 CD53 CLDN5 CYB561 EPHA2 EPHA3 EPHA4 EPHA5 EPHA7 EPHA8 EPHB1 EPHB2 FFAR3 GJB1 GPR151 GPR152 GPR161 GPR42 GRIP1 HERPUD2 HIBADH KASH5 MS4A3 SGPL1 SLC10A2 SLC13A4 SLC16A2 SLC35H1 SRC SSMEM1 TM4SF18 TMEM237 TRHR TSPO2 YIPF6
Entrez ID		7122	1946
HPRD ID		03654	03324
Ensembl ID		ENSG00000184113	ENSG00000184349
Uniprot IDs		D3DX19 O00501	D6RDV5 P52803
PDB IDs			2X11 3MX0 4BK5 4BKA 4L0P 4M4R
Enriched GO Terms of Interacting Partners?		Membrane	Ephrin Receptor Activity Ephrin Receptor Signaling Pathway Transmembrane-ephrin Receptor Activity Membrane Transmembrane Receptor Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Protein Tyrosine Kinase Activity Plasma Membrane Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Neuron Projection Guidance Axon Guidance Protein Kinase Activity Regulation Of Cell Junction Assembly Axon Guidance Receptor Activity Fasciculation Of Motor Neuron Axon Kinase Activity Dendrite Axonal Fasciculation Neuron Projection Fasciculation Retinal Ganglion Cell Axon Guidance Fasciculation Of Sensory Neuron Axon G Protein-coupled Receptor Activity Central Nervous System Projection Neuron Axonogenesis Ephrin Receptor Binding Regulation Of ERK1 And ERK2 Cascade Optic Nerve Morphogenesis Hindbrain Tangential Cell Migration Central Nervous System Neuron Axonogenesis Signal Transduction Neuron Projection Development Channel Activity Positive Regulation Of Cell Junction Assembly Cell Migration Renal Water Transport Nephric Duct Morphogenesis Growth Factor Binding Neuron Recognition Cell Recognition Peptidyl-tyrosine Phosphorylation Positive Regulation Of Bicellular Tight Junction Assembly Intestinal Epithelial Cell Development Cell Surface Receptor Signaling Pathway Nervous System Development Anchoring Junction Regulation Of GTPase Activity G Protein-coupled Receptor Signaling Pathway Cell Migration In Hindbrain Cell Motility Water Channel Activity
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