NR2E1 and ATN1

Number of citations of the paper that reports this interaction (PubMedID 22675500)
42

Data Source:
BioGRID (two hybrid)

		NR2E1	ATN1
Description		nuclear receptor subfamily 2 group E member 1	atrophin 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Perinuclear Region Of Cytoplasm Anchoring Junction
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Enzyme Binding Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Behavioral Fear Response Positive Regulation Of Neuroblast Proliferation Aggressive Behavior Regulation Of DNA-templated Transcription Apoptotic Process Nervous System Development Neuroblast Proliferation Brain Development Visual Perception Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Dentate Gyrus Development Amygdala Development Olfactory Bulb Development Layer Formation In Cerebral Cortex Forebrain Generation Of Neurons Cerebral Cortex Neuron Differentiation Central Nervous System Neuron Differentiation Anterior Commissure Morphogenesis Cerebral Cortex Development Cell Differentiation Extracellular Matrix Organization Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Social Behavior Camera-type Eye Development Negative Regulation Of Apoptotic Process Astrocyte Cell Migration Cell Fate Commitment Negative Regulation Of Neuron Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Astrocyte Differentiation Negative Regulation Of Astrocyte Differentiation Regulation Of Dendrite Morphogenesis Regulation Of Cellular Component Organization Retina Development In Camera-type Eye Regulation Of Timing Of Neuron Differentiation Long-term Synaptic Potentiation Neural Precursor Cell Proliferation Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Stem Cell Proliferation	Negative Regulation Of Transcription By RNA Polymerase II Cell Killing Spermatogenesis Central Nervous System Development Determination Of Adult Lifespan Male Gonad Development Post-embryonic Development Cell Migration Maintenance Of Cell Polarity Response To Food Multicellular Organism Growth Positive Regulation Of DNA-templated Transcription Neuron Apoptotic Process
Pathways		Nuclear Receptor transcription pathway Regulation of PTEN gene transcription	Regulation of PTEN gene transcription
Drugs
Diseases			Dentatorubropallidoluysian atrophy (DRPLA)
GWAS			Refractive error ( 32231278)
Interacting Genes		7 interacting genes: ATN1 DNMT3L ERBIN KDM1A NSD1 RAB27B RERE	126 interacting genes: AGRN ALG13 ARF3 ATRX BAG3 BAG6 BAIAP2 CACNB1 CASP1 CASP3 CBFA2T2 CHRD CPAP CRACR2A CRIP2 CSNK2A1 CTNND2 DGCR6L DMPK DMRT3 DVL1 DVL2 ECM1 EFEMP1 EFEMP2 ETNK2 EWSR1 FBLN1 FBLN2 FBLN5 FXR1 FXR2 GAPDH GCC1 GIGYF1 GRN HGS HINFP HNRNPF HSPG2 ITCH JAG2 KAT6A KAT6B KAT7 KRT31 KRTAP12-2 KRTAP15-1 KRTAP19-2 KRTAP19-5 KRTAP4-12 KRTAP6-2 KRTAP9-3 LENG8 LRP2 LTBP1 LTBP4 LYST MAGI1 MAGI2 MAP7D1 MBP MDFI MEGF11 MEGF6 MEGF8 NCK2 NELL1 NELL2 NOC2L NR2E1 OLIG3 P4HA3 PCSK5 PDCD6IP PFKL PIN1 PITX1 PITX2 PLSCR1 PRRC2A PRRC2B PSMA3 PSME3 RAD54L2 RBFOX1 RBFOX2 RBM10 RBM14 RBM4B RBPMS RCHY1 RERE RHOXF2 RNF115 RNF31 RUNX1T1 SAXO4 SH3RF1 SHANK3 SIAH1 SIAH2 SLC25A48 SLIT1 SPAG5 SS18L1 SSPOP STXBP4 SYVN1 TEKT3 TEP1 TLE1 TLE5 TNFAIP8 TRIP6 TSC1 USP2 USP54 VIM WDR5 WWP1 WWP2 YAP1 ZMYND8 ZNF503 ZSWIM8
Entrez ID		7101	1822
HPRD ID		07230	06311
Ensembl ID		ENSG00000112333	ENSG00000111676
Uniprot IDs		B6ZGT9 Q9Y466	P54259 Q86V38
PDB IDs		4XAJ
Enriched GO Terms of Interacting Partners?		Transcription Corepressor Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Nuclear Androgen Receptor Binding Regulation Of Chromatin Organization Chromatin Remodeling Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Transcription Coactivator Activity Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Post-embryonic Development Regulation Of Nucleobase-containing Compound Metabolic Process Cerebellar Purkinje Cell Layer Maturation Chromatin Binding Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Basal Protein Localization Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Radial Glia Guided Migration Of Purkinje Cell Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Epigenetic Programing Of Female Pronucleus ErbB-2 Class Receptor Binding Positive Regulation Of Biosynthetic Process Protein Demethylase Activity Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Histone H3K36 Dimethyltransferase Activity Establishment Or Maintenance Of Cell Polarity Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Branching Morphogenesis Of A Nerve Platelet Dense Granule Membrane Response To Fungicide MRF Binding Guanine Metabolic Process Chorionic Trophoblast Cell Differentiation Autosome Genomic Imprinting Negative Regulation Of Heterochromatin Formation Negative Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Macromolecule Biosynthetic Process Methylation	Protein Binding Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Developmental Process Extracellular Matrix Structural Constituent Positive Regulation Of Metabolic Process Regulation Of Gene Expression Calcium Ion Binding Negative Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Communication Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Protein Stabilization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Intermediate Filament Transcription Corepressor Activity Regulation Of Protein Stability Elastic Fiber Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Cell Surface Receptor Signaling Pathway Wnt Signaling Pathway System Development Apoptotic Process DNA-binding Transcription Factor Binding Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Programmed Cell Death Cell Death Histone H3 Acetyltransferase Activity Regulation Of Cell Population Proliferation Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Cell Projection Organization Signal Transduction Positive Regulation Of RNA Metabolic Process
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