BMP3

Description		bone morphogenetic protein 3
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Cytokine Activity Growth Factor Activity BMP Receptor Binding
	Biological Process	Skeletal System Development Ossification Osteoblast Differentiation Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Cell-cell Signaling Cell Differentiation Negative Regulation Of Ossification Positive Regulation Of Transcription By RNA Polymerase II Cartilage Development
Pathways
Drugs
Diseases
GWAS		Cataracts ( 34127677) Corneal astigmatism ( 30306274) Height ( 18391951) Low myopia vs hyperopia ( 33830181) Myopia ( 27182965) Optic disc size ( 31809533) Pubertal anthropometrics ( 23449627) Refractive astigmatism ( 30306274) Refractive error ( 23396134 32231278) Retinal detachment or retinal break ( 31816047) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Novel Interacting Genes		6 novel interacting genes: COL4A1 COL4A2 KDM1A PRMT6 TGFB1 TLE3
Interacting Genes		6 interacting genes: COL4A1 COL4A2 KDM1A PRMT6 TGFB1 TLE3
Entrez ID		651
HPRD ID		00208
Ensembl ID		ENSG00000152785
Uniprot IDs		P12645
PDB IDs		2QCQ
Enriched GO Terms of Interacting Partners?		Collagen Type IV Trimer Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Extracellular Structure Organization Extracellular Matrix Organization Extracellular Matrix Structural Constituent Conferring Tensile Strength Angiogenesis Regulation Of Neuroblast Proliferation Positive Regulation Of Stem Cell Proliferation Extracellular Matrix Collagen Trimer Response To Transforming Growth Factor Beta Cellular Response To Transforming Growth Factor Beta Stimulus Branch Elongation Involved In Mammary Gland Duct Branching Positive Regulation Of Microglia Differentiation Cellular Response To Ionizing Radiation Epithelial To Mesenchymal Transition Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Stem Cell Proliferation Cellular Response To Acetaldehyde Histone H2AR3 Methyltransferase Activity Basement Membrane Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Neural Precursor Cell Proliferation Extracellular Matrix Structural Constituent Regulation Of Multicellular Organismal Development Positive Regulation Of Primary MiRNA Processing Negative Regulation Of RNA Metabolic Process Embryonic Liver Development Regulation Of Epithelial To Mesenchymal Transition Mesenchymal Cell Differentiation Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Histone H3R2 Methyltransferase Activity Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Multicellular Organismal Process Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Frontal Suture Morphogenesis Response To Ionizing Radiation Regulation Of DNA Recombination Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Histone Arginine N-methyltransferase Activity Regulation Of Cold-induced Thermogenesis Morphogenesis Of A Branching Epithelium Cell Maturation Morphogenesis Of A Branching Structure
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