TLE1 and NKX2-5

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		TLE1	NKX2-5
Description		TLE family member 1, transcriptional corepressor	NK2 homeobox 5
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Beta-catenin-TCF Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Protein-containing Complex Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex Nkx-2.5 Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding Identical Protein Binding DNA-binding Transcription Factor Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Signal Transduction Animal Organ Morphogenesis Positive Regulation Of Gene Expression Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Anoikis	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Heart Looping Heart Morphogenesis Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Cardiac Conduction System Development Atrioventricular Node Development Bundle Of His Development Purkinje Myocyte Differentiation Aortic Valve Morphogenesis Cardiac Ventricle Morphogenesis Cardiac Ventricle Formation Right Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Atrial Cardiac Muscle Tissue Development Apoptotic Process Involved In Heart Morphogenesis Septum Secundum Development Proepicardium Development Pulmonary Myocardium Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Apoptotic Process Heart Development Adult Heart Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Sodium Ion Transport Negative Regulation Of Myotube Differentiation Hemopoiesis Cell Differentiation Epithelial Cell Differentiation Thyroid Gland Development Embryonic Heart Tube Development Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Differentiation Positive Regulation Of Heart Contraction Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Cardiac Muscle Tissue Development Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cardioblast Differentiation Ventricular Cardiac Myofibril Assembly Cardiac Muscle Cell Differentiation Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Development Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Pharyngeal System Development Cardiac Muscle Cell Proliferation Regulation Of Cardiac Muscle Cell Proliferation Heart Contraction Cardiac Muscle Contraction Positive Regulation Of Transcription Initiation By RNA Polymerase II Heart Trabecula Formation Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Atrioventricular Node Cell Development Atrioventricular Node Cell Fate Commitment Embryonic Heart Tube Left/right Pattern Formation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cardiac Conduction Epithelial Cell Apoptotic Process Negative Regulation Of Epithelial Cell Apoptotic Process
Pathways		Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes Negative Regulation of CDH1 Gene Transcription	YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors Cardiogenesis Cardiogenesis
Drugs
Diseases			Tetralogy of Fallot Congenital nongoitrous hypothyroidism (CHNG) Atrial septal defect
GWAS		Appendicular lean mass ( 33097823) Forehead morphology ( 29921221) Hippocampal atrophy ( 22745009) Lung adenocarcinoma ( 28604730) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Moderate-to-late spontaneous preterm birth ( 31194736) Rheumatoid arthritis ( 30891314) Schizophrenia ( 25056061) Type 2 diabetes ( 22885922 32499647 30718926 30297969 30054458 28869590 26818947 24509480) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral fat ( 22589738)	Atrial fibrillation ( 29892015 30061737) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heart rate ( 23583979) Infantile hypertrophic pyloric stenosis ( 22306654) PR interval ( 20062060 30046033 32439900) Resting heart rate ( 27798624) Stroke ( 26089329) TPE interval (resting) ( 32386560)
Interacting Genes		87 interacting genes: ANXA7 APH1A ARL3 ARL4D ATN1 BARHL1 BCL2L1 BID BTBD2 CCL18 CDK1 CDKN1A CDKN2C CELF3 CRCT1 CSNK2B CTNNB1 DAZAP2 DLEU1 DNAH5 EIF2S2 EN1 ERH ESRRG FOXA1 FOXA2 FOXA3 FOXG1 FUBP1 FXYD6 GADD45A GKAP1 GOLM1 GRB7 GSK3B GSTM4 HES1 HES6 HESX1 HHEX HLA-DQA1 HMGB1 HNF1A HSPE1 IL6ST KDM6A KIAA0408 KIF27 LEF1 MORF4L2 MPHOSPH6 MSX1 MSX2 NKX2-5 NUDT21 PAFAH1B3 PAX9 PCDHA4 PEX2 PFN1 POLB POLE2 PRDM1 PSMD11 RAP1B RCC1 RNF10 RPA2 RUNX1 RUNX3 SAT1 SERPINB9 SIX1 SIX2 SIX3 SIX6 SMN1 SNRPG TCF3 TCF4 TK1 TLE2 TLX1 TLX2 TSC22D1 UTY ZFP64	20 interacting genes: CAMTA2 CSNK2A1 FBXO25 FLT4 FOXH1 GATA4 HDAC1 HIPK1 HIPK2 JARID2 KDM6A KPNA4 KRTAP8-1 RBPMS SHOX SRF TBX2 TBX5 TLE1 TRIP10
Entrez ID		7088	1482
HPRD ID		02557	02787
Ensembl ID		ENSG00000196781	ENSG00000183072
Uniprot IDs		B4DEF9 Q04724 Q59EF7	A0A0S2Z383 A0A0S2Z3K2 E5RH49 P52952
PDB IDs		1GXR 2CE8 2CE9 4OM2 4OM3 5MWJ	3RKQ 4S0H 6WC2 6WC5
Enriched GO Terms of Interacting Partners?		Sequence-specific Double-stranded DNA Binding Chromatin Developmental Process Nucleus DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Cis-regulatory Region Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Animal Organ Development Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Regulator Complex Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Developmental Process Sequence-specific DNA Binding Pattern Specification Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Cell Differentiation DNA-binding Transcription Factor Activity Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regionalization Negative Regulation Of DNA-templated Transcription Cellular Developmental Process Negative Regulation Of RNA Biosynthetic Process Cell Population Proliferation Regulation Of Macromolecule Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Differentiation Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Mesenchymal Cell Differentiation Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Developmental Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Positive Regulation Of Metabolic Process Transcription Corepressor Binding	Embryonic Morphogenesis DNA-binding Transcription Factor Binding Cardiocyte Differentiation Sequence-specific DNA Binding Embryonic Camera-type Eye Morphogenesis Heart Looping Nucleoplasm Embryonic Heart Tube Morphogenesis Chromatin Nucleus Anatomical Structure Morphogenesis Anatomical Structure Formation Involved In Morphogenesis RNA Polymerase II-specific DNA-binding Transcription Factor Binding Aorta Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Blood Vessel Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Embryonic Heart Tube Anterior/posterior Pattern Specification Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Eye Morphogenesis Positive Regulation Of Biosynthetic Process Epithelial Tube Morphogenesis Muscle Cell Differentiation Transcription Regulator Complex Lens Induction In Camera-type Eye Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Histone Deacetylase Binding Positive Regulation Of Metabolic Process Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Macromolecule Biosynthetic Process Tube Morphogenesis Animal Organ Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Muscle Tissue Development Embryonic Retina Morphogenesis In Camera-type Eye Morphogenesis Of An Epithelium Anterior/posterior Pattern Specification Iris Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Population Proliferation Eye Morphogenesis Positive Regulation Of Cell Population Proliferation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?