NR2F1 and POU2F2

Number of citations of the paper that reports this interaction (PubMedID 8622679)
74

Data Source:
BioGRID (pull down)

		NR2F1	POU2F2
Description		nuclear receptor subfamily 2 group F member 1	POU class 2 homeobox 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Retinoic Acid-responsive Element Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Signal Transduction Nervous System Development Negative Regulation Of Neuron Projection Development Cell Differentiation Intracellular Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Humoral Immune Response Positive Regulation Of Interleukin-6 Production Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Virus
Pathways		Nuclear Receptor transcription pathway	RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes
Drugs		beta-Naphthoflavone
Diseases
GWAS		Adult body size ( 32376654) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical volume ( 32963231) Left–right brain asymmetry ( 33723403) PR interval ( 32439900) Subcortical volume (MOSTest) ( 32665545)	Alcohol consumption (drinks per week) ( 30643258) Chronotype ( 30696823) Eosinophil count ( 32888494) Meat-related diet ( 32066663) Monocyte count ( 32888494) Prostate cancer ( 29892016) Prostate cancer (advanced) ( 29892016)
Interacting Genes		28 interacting genes: AHR BCL11A BCL11B CBX5 COPS2 EEF1D ESR1 FOXP1 FOXP2 FOXP4 GTF2B HNF4A ISL1 MAP6 MCPH1 MEF2C NCOA1 NCOA2 NCOA3 NCOR2 NSD1 PFDN1 PHB2 POU2F2 RXRA SP1 THRA UBC	15 interacting genes: AR ESR1 GAPDH HMGA1 HMGB2 MNAT1 MSX2 NR2F1 NR3C1 PGR POU2AF1 RXRA TBP TXNRD1 XRCC6
Entrez ID		7025	5452
HPRD ID		00584	01251
Ensembl ID		ENSG00000175745	ENSG00000028277
Uniprot IDs		A0A8V8TQQ6 P10589	A0A8I5KYI8 B5ME60 H0YLL6 P09086
PDB IDs		2EBL	1HDP 9DZM
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Chromatin Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Intracellular Receptor Signaling Pathway Sequence-specific DNA Binding Nuclear Receptor Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleoplasm DNA-templated Transcription Sequence-specific Double-stranded DNA Binding Negative Regulation Of Metabolic Process DNA Binding Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nuclear Estrogen Receptor Binding Transcription Cis-regulatory Region Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Nucleus Nuclear Receptor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Thyroid Hormone Receptor Signaling Pathway TBP-class Protein Binding Positive Regulation Of Macromolecule Metabolic Process Hormone-mediated Signaling Pathway Rhythmic Process Response To Lipid	Nuclear Receptor Activity Estrogen Response Element Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Nuclear Steroid Receptor Activity Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Steroid Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Nuclear Receptor-mediated Signaling Pathway RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Intracellular Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Sequence-specific DNA Binding Transcription Cis-regulatory Region Binding Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Hormone-mediated Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Nucleus Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Enzyme Binding Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Transcription Regulator Complex Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Metabolic Process POU Domain Binding TFIIB-class Transcription Factor Binding Nucleoplasm Transcription Coregulator Binding
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