TFAP2B and CITED2

Number of citations of the paper that reports this interaction (PubMedID 11744733)
0

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BioGRID (pull down)

		TFAP2B	CITED2
Description		transcription factor AP-2 beta	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding	Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Histone Acetyltransferase Binding SMAD Binding LBD Domain Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Molecular Function Activator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Glucose Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Nervous System Development Sensory Organ Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Gene Expression Retina Layer Formation Regulation Of BMP Signaling Pathway Forelimb Morphogenesis Hindlimb Morphogenesis Aorta Morphogenesis Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Skin Development Fat Cell Differentiation Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Sympathetic Nervous System Development Smooth Muscle Tissue Development Regulation Of Insulin Secretion Neuron Apoptotic Process Distal Tubule Development Collecting Duct Development Metanephric Nephron Development Ductus Arteriosus Closure	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Vasculogenesis Response To Hypoxia In Utero Embryonic Development Trophectodermal Cell Differentiation Neural Tube Formation Neural Tube Closure Liver Development Embryonic Placenta Development Vasculature Development Heart Looping Lens Morphogenesis In Camera-type Eye Hematopoietic Progenitor Cell Differentiation Leukocyte Differentiation Determination Of Left/right Asymmetry In Lateral Mesoderm Outflow Tract Morphogenesis Regulation Of Animal Organ Formation Endocardial Cushion Development Ventricular Septum Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Determination Of Left/right Symmetry Central Nervous System Development Peripheral Nervous System Development Heart Development Sex Determination Cell Population Proliferation Male Gonad Development Response To Mechanical Stimulus Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cranial Nerve Morphogenesis Positive Regulation Of Cell-cell Adhesion Cell Differentiation Adrenal Gland Development Negative Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Granulocyte Differentiation Response To Fluid Shear Stress Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Adrenal Cortex Formation Skeletal Muscle Cell Differentiation Nodal Signaling Pathway Negative Regulation Of Apoptotic Process Response To Estrogen Positive Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Decidualization Spleen Development Thymus Development Embryonic Camera-type Eye Morphogenesis Erythrocyte Development Uterus Development Embryonic Process Involved In Female Pregnancy Bone Morphogenesis Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Embryonic Heart Tube Left/right Pattern Formation Left/right Pattern Formation Pulmonary Artery Morphogenesis Cardiac Neural Crest Cell Development Involved In Heart Development Determination Of Heart Left/right Asymmetry Left/right Axis Specification Cellular Response To Growth Factor Stimulus Cellular Response To Hypoxia Cellular Senescence Positive Regulation Of Male Gonad Development
Pathways		SUMOylation of transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Specification of the neural plate border Specification of the neural plate border	Regulation of gene expression by Hypoxia-inducible Factor TFAP2 (AP-2) family regulates transcription of other transcription factors Activation of the TFAP2 (AP-2) family of transcription factors FOXO-mediated transcription of cell death genes
Drugs
Diseases		Char syndrome
GWAS		Adiposity ( 19557161) Adult body size ( 32376654) Age at adiposity rebound ( 31840077) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Blood urea nitrogen levels ( 31152163 29403010) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body fat distribution (arm fat ratio) ( 30664634) Body mass index ( 31453325 29381148 28892062 20935630 28448500 24861553 26961502 23563607 25673413) Body mass index (adult) ( 28430825) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index variance ( 31453325) Body size at age 10 ( 32376654) Childhood body mass index ( 33045005 26604143) Chronotype ( 30696823) Fruit consumption ( 32066663) Glaucoma (primary open-angle) ( 33627673) Hand grip strength ( 29691431) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hip circumference ( 31453325 25673412) Hip circumference variance ( 31453325) Intraocular pressure ( 29617998) Keratoconus ( 33649486) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (drugs used in diabetes) ( 31015401) Metabolic syndrome (bivariate traits) ( 21386085) Myopia ( 27182965) Nevus count or cutaneous melanoma ( 32341527) Obese vs. thin ( 30677029) Obesity ( 23563607) Obesity (extreme) ( 21935397) Refractive error ( 32231278) Renal function-related traits (BUN) ( 22797727) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Type 2 diabetes ( 30054458 32499647 30297969) Urolithiasis ( 30975718) Waist circumference ( 25673412 31453325) Waist circumference variance ( 31453325) Waist-hip ratio ( 25673412) Walking pace ( 33128006)	Alanine aminotransferase levels ( 33547301) Albumin-globulin ratio ( 29403010) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Blood trace element (Se levels) ( 23720494) Caudate volume in trauma-exposed individuals ( 29187748) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 30224653) Glycated hemoglobin levels ( 28898252) HDL cholesterol ( 20686565 24097068) HDL cholesterol levels ( 32203549 28334899) IgA levels ( 28628107) Mean corpuscular hemoglobin ( 28453575 19862010 28017375 20139978 23263863) Mean corpuscular volume ( 19862010 28017375 32888494 20139978 23263863 28453575) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Non-albumin protein levels ( 29403010) Obesity-related traits ( 23251661) Red blood cell traits ( 23222517) Systolic blood pressure ( 30224653) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Triglyceride levels ( 32203549) Triglycerides ( 25961943) Urate levels in lean individuals ( 25811787)
Interacting Genes		16 interacting genes: AURKA CITED1 CITED2 CITED4 H2AC6 HCRTR2 LZTR1 MCM3 MYC NDRG1 SSBP4 SYT4 UBE2I VEGFA VPS11 YEATS4	11 interacting genes: CREBBP EP300 FBXL5 HIF1A LHX2 LHX3 MAPK1 TBP TFAP2A TFAP2B TFAP2C
Entrez ID		7021	10370
HPRD ID		03360	04245
Ensembl ID		ENSG00000008196	ENSG00000164442
Uniprot IDs		Q92481	A0A0A0MTM3 D9ZGF1 Q99967
PDB IDs		8J0Q	1P4Q 1R8U 7LVS 7QGS
Enriched GO Terms of Interacting Partners?		Regulation Of Kidney Development Cellular Response To Decreased Oxygen Levels Cellular Response To Hypoxia Cellular Response To Oxygen Levels LBD Domain Binding Perinuclear Region Of Cytoplasm Response To Estrogen Vasculogenesis Positive Regulation Of Reproductive Process Tube Morphogenesis Response To Hypoxia Response To Decreased Oxygen Levels Response To Growth Factor Branching Morphogenesis Of An Epithelial Tube Morphogenesis Of An Epithelium Response To Oxygen Levels Molecular Function Activator Activity Morphogenesis Of A Branching Structure Morphogenesis Of A Branching Epithelium Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Tissue Morphogenesis Nucleoplasm Regulation Of DNA Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Branching Involved In Ureteric Bud Morphogenesis Pigmentation Negative Regulation Of Apoptotic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Regulation Of Cell Division Transcription Coregulator Binding Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Regulation Of Reproductive Process Positive Regulation Of Dense Core Granule Exocytosis Negative Regulation Of Retrograde Trans-synaptic Signaling By Neuropeptide Regulation Of Postsynaptic Dense Core Vesicle Exocytosis Negative Regulation Of Short-term Neuronal Synaptic Plasticity SUMO Conjugating Enzyme Activity VEGF-A Complex Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Basophil Chemotaxis Regulation Of Primary Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Metabolic Process Regulation Of Apoptotic Process	Chromatin Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Transcription Coactivator Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Anatomical Structure Formation Involved In Morphogenesis DNA Binding Animal Organ Development Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Anatomical Structure Morphogenesis Histone H3K27 Acetyltransferase Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Histone H3K18 Acetyltransferase Activity Regulation Of Primary Metabolic Process N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Sequence-specific DNA Binding Chromatin Binding Regulation Of Metabolic Process Animal Organ Morphogenesis P53 Binding Transcription Regulator Complex Nucleus Cerebral Cortex Development Regulation Of Gene Expression DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process N-terminal Protein Amino Acid Acetylation Transcription By RNA Polymerase II Peptidyl-lysine Acetylation Regulation Of Cellular Response To Heat Developmental Process Regulation Of Cellular Response To Growth Factor Stimulus Mammary Gland Epithelial Cell Proliferation Regulation Of Ossification Negative Regulation Of DNA-templated Transcription
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