TF and TMEM52B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TF	TMEM52B
Description		transferrin	transmembrane protein 52B
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Early Endosome Late Endosome Endoplasmic Reticulum Lumen Plasma Membrane Clathrin-coated Pit Basal Plasma Membrane Cell Surface Endosome Membrane Membrane Apical Plasma Membrane Endocytic Vesicle Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Vesicle Secretory Granule Lumen Basal Part Of Cell Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Blood Microparticle HFE-transferrin Receptor Complex	Membrane Extracellular Exosome
	Molecular Function	Iron Ion Binding Protein Binding Ferrous Iron Binding Ferric Iron Binding Enzyme Binding Iron Chaperone Activity Transmembrane Transporter Binding Metal Ion Binding Transferrin Receptor Binding	Protein Binding
	Biological Process	Monoatomic Ion Transport Iron Ion Transport Intracellular Iron Ion Homeostasis Cell Surface Receptor Signaling Pathway Response To Bacterium Antibacterial Humoral Response Osteoclast Differentiation Regulation Of Protein Stability Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Receptor-mediated Endocytosis Multicellular Organismal-level Iron Ion Homeostasis Cellular Response To Iron Ion Iron Ion Export Across Plasma Membrane
Pathways		Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Post-translational protein phosphorylation Iron uptake and transport Transferrin endocytosis and recycling
Drugs		Cisplatin Isoflurophate Aluminium Iron Zinc Manganese Copper Dichlorvos Zinc acetate Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate Aluminium phosphate Aluminum acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Alcohol consumption (transferrin glycosylation) ( 21665994) HDL cholesterol levels ( 32203549) Hepcidin levels ( 21785125) Hereditary hemochromatosis-related traits (HFE mutation homozygotes) ( 25457201) Iron status biomarkers ( 21208937 21483845 25224454 19084217) Iron status biomarkers (iron levels) ( 28334935 33536631 25352340) Iron status biomarkers (total iron binding capacity) ( 33536631 28334935) Iron status biomarkers (transferrin levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 33536631 25352340 28334935) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean corpuscular volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Red blood cell count ( 32888494) Red cell distribution width ( 27863252 32888494)
Interacting Genes		47 interacting genes: AQP9 CALR CANX CLDN5 CPLX4 CUBN DRD2 ELOVL4 ERGIC3 FAM209A FAM210B FKBP7 GJB1 GOLM1 GPR42 GPX8 GRB2 HSD17B13 HSP90AA1 IGF1 IGF2 IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 LAMC3 LCOR LEUTX PGRMC2 RMDN3 RSPH1 SH3BP2 SLC10A6 SLC26A6 SLC35H1 SMAD3 SORT1 SPINT1 SYT2 TFR2 TFRC TIMELESS TMEM52B TUBB3 VKORC1	70 interacting genes: ALG3 APOD APOL2 APOL3 BET1 BTN2A2 C1GALT1 C3orf52 CLDN19 CLDN4 CNIH1 CNIH3 CRYAA CSGALNACT2 DNAJC30 EMD FXYD3 GAST GPR25 GPR37L1 IGFBP5 INSIG2 ITGAM JAGN1 LHFPL5 LPAR3 LTC4S MAL MARCHF2 MIP MS4A13 NINJ2 NRM NSG1 ORMDL1 PEDS1-UBE2V1 PGAP2 PLN PLP1 RTP2 SEC22A SERP1 SLC30A2 SLC30A8 SLC35A4 SLC35B4 SLC38A7 SMIM1 TF TMEM100 TMEM107 TMEM109 TMEM128 TMEM147 TMEM14C TMEM203 TMEM218 TMEM267 TMEM50B TMEM54 TMEM60 TMEM86B TMEM97 TMUB2 TRAM1L1 TRARG1 VAMP3 VAMP5 YIPF6 ZDHHC15
Entrez ID		7018	120939
HPRD ID		01811	08709
Ensembl ID		ENSG00000091513	ENSG00000165685
Uniprot IDs		A0PJA6 P02787 Q06AH7	Q4KMG9
PDB IDs		1A8E 1A8F 1B3E 1BP5 1BTJ 1D3K 1D4N 1DTG 1FQE 1FQF 1JQF 1N7W 1N7X 1N84 1OQG 1OQH 1RYO 1SUV 2HAU 2HAV 2O7U 2O84 3FGS 3QYT 3S9L 3S9M 3S9N 3SKP 3V83 3V89 3V8X 3VE1 4H0W 4X1B 4X1D 5DYH 5H52 5WTD 5X5P 5Y6K 6CTC 6D03 6D04 6D05 6JAS 6SOY 6SOZ 6UJ6 7FFM 7FFU 7Q1L 8BRC 9H49 9H4V
Enriched GO Terms of Interacting Partners?		Insulin-like Growth Factor II Binding Insulin-like Growth Factor Binding Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Insulin-like Growth Factor I Binding Growth Factor Binding Endoplasmic Reticulum Lumen Insulin-like Growth Factor Binding Protein Complex Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Insulin-like Growth Factor Ternary Complex Type B Pancreatic Cell Proliferation Striated Muscle Cell Differentiation Osteoblast Differentiation Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Growth Transferrin Receptor Activity Receptor-mediated Endocytosis Muscle Cell Differentiation Regulation Of Cell Growth Response To Estradiol Positive Regulation Of Activated T Cell Proliferation Insulin Receptor Signaling Pathway Fibronectin Binding Morphogenesis Of A Branching Structure Intracellular Chemical Homeostasis Response To Iron Ion Cellular Developmental Process Epithelial Cell Proliferation Regulation Of Glucose Metabolic Process Protein Binding Positive Regulation Of Cellular Component Organization Developmental Process Endocytosis Regulation Of Activated T Cell Proliferation Positive Regulation Of T Cell Proliferation HFE-transferrin Receptor Complex Carbohydrate Transmembrane Transport Polyol Transmembrane Transport Iron Ion Transport Carbohydrate Transport Cellular Homeostasis Branching Involved In Labyrinthine Layer Morphogenesis Exocrine Pancreas Development Positive Regulation Of Transport Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Cell Adhesion Transferrin Transport Brush Border Membrane Chemical Homeostasis Protein Folding In Endoplasmic Reticulum	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Establishment Of Protein Localization To Membrane Protein Binding Golgi Membrane Localization Within Membrane Establishment Of Protein Localization To Plasma Membrane Cellular Localization Protein Insertion Into Membrane Establishment Of Protein Localization Zinc:proton Antiporter Activity Nuclear Outer Membrane Protein Localization To Membrane Paracellular Transport Protein Localization To Postsynapse Lipid Binding SNAP Receptor Activity Transmembrane Transport Structural Constituent Of Myelin Sheath Zinc Ion Import Into Organelle Intestinal Epithelial Cell Development Pyrimidine Nucleotide-sugar Transmembrane Transport Vesicle-mediated Transport
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