TCF12 and SPTBN5

		TCF12	SPTBN5
Description		transcription factor 12	spectrin beta, non-erythrocytic 5
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Speck RNA Polymerase II Transcription Regulator Complex	Cytoplasm Cytosol Cytoskeleton Microtubule Associated Complex Plasma Membrane Spectrin Membrane Cell Junction Cortical Cytoskeleton Cortical Actin Cytoskeleton Photoreceptor Connecting Cilium Cell Projection Organelle Apical Cortex Photoreceptor Disc Membrane Plasma Membrane Bounded Cell Projection
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding CAMP Response Element Binding BHLH Transcription Factor Binding SMAD Binding Protein Heterodimerization Activity Protein Dimerization Activity E-box Binding HMG Box Domain Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Opsin Binding Actin Binding Cytoskeletal Protein Binding Kinesin Binding Spectrin Binding Myosin Tail Binding Dynactin Binding Identical Protein Binding Dynein Intermediate Chain Binding Actin Filament Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Immune Response Nervous System Development Muscle Organ Development Gene Expression Positive Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Gonadotropin-releasing Hormone	Golgi Organization Lysosomal Transport Actin Cytoskeleton Organization Actin Filament Capping
Pathways		Myogenesis Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs NGF-stimulated transcription NGF-stimulated transcription Negative Regulation of CDH1 Gene Transcription TGFBR3 expression	NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein B levels ( 32203549) Body mass index ( 28892062) Glaucoma (primary open-angle) ( 29891935 33627673) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Male-pattern baldness ( 28196072) Mean platelet volume ( 27863252 32888494) Triglyceride levels ( 32154731) Type 2 diabetes ( 30297969)	Waist circumference adjusted for body mass index ( 28552196 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		78 interacting genes: ACTB ADAM10 AIRIM ARL16 ARMC8 ASCL4 BCL2L10 BMERB1 BMF CDKN2C CFAP206 CKS1B CLCNKA CRCP CREBBP DDX6 DGCR6 EDRF1 EP300 EXOC8 FRMD6 GRB7 HAND1 HOPX ID1 ID2 ID3 LAMTOR5 LNX1 LYSMD1 MAPK6 MAPKBP1 MLLT6 MORN4 MSC MYF6 MYO15B NAGK NEK6 NEUROD1 NEUROG1 NGLY1 NHLH2 OLIG3 OSGIN1 PIN1 PRKAB2 PRSS23 PSMA1 PTF1A QARS1 RBM8A RNASEL RSL24D1 RUNX1T1 SCG3 SLC12A1 SLC24A1 SOX10 SOX8 SPG21 SPTBN5 SRI STAT5A STK16 TAF4 TAL2 TBC1D21 TBP TCF21 TCF3 TMEM132D TRIM72 TSNAX VPS28 WTAP YKT6 ZNF688	4 interacting genes: FBN1 MTDH RNF10 TCF12
Entrez ID		6938	51332
HPRD ID		02725	10438
Ensembl ID		ENSG00000140262	ENSG00000137877
Uniprot IDs		F5GY10 Q99081	Q9NRC6
PDB IDs		2KNH 4JOL
Enriched GO Terms of Interacting Partners?		Protein Dimerization Activity Chromatin DNA-binding Transcription Factor Binding E-box Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Cell Fate Commitment Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Animal Organ Development Regulation Of Macromolecule Biosynthetic Process Neuron Differentiation BHLH Transcription Factor Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Histone H3K27 Acetyltransferase Activity Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Biosynthetic Process Nucleus Regulation Of Metabolic Process RNA Polymerase II Transcription Regulator Complex Striated Muscle Tissue Development Transcription Regulator Inhibitor Activity Nucleoplasm Regulation Of Macromolecule Metabolic Process Tau Protein Binding Oligodendrocyte Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Thigmotaxis Branchiomeric Skeletal Muscle Development Muscle Tissue Development Cytoplasm Negative Regulation Of Macromolecule Biosynthetic Process Cell Differentiation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Developmental Process	Protein Kinase A Signaling Sequestering Of Extracellular Ligand From Receptor Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Sequestering Of BMP In Extracellular Matrix Positive Regulation Of Response To Food Sequestering Of TGFbeta In Extracellular Matrix Regulation Of Multicellular Organismal Development Extracellular Negative Regulation Of Signal Transduction Response To Peptide Hormone Positive Regulation Of Appetite Regulation Of Osteoclast Development Post-embryonic Eye Morphogenesis Cellular Response To Insulin-like Growth Factor Stimulus Negative Regulation Of Osteoclast Development Negative Regulation Of Cell Development Extracellular Matrix Constituent Conferring Elasticity Regulation Of Cell Differentiation Activation Of Protein Kinase A Activity Regulation Of Developmental Process Transcription Cis-regulatory Region Binding HMG Box Domain Binding Response To Gonadotropin-releasing Hormone CAMP Response Element Binding Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane Intercellular Canaliculus Microfibril Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Response To Food Negative Regulation Of Glial Cell Proliferation Positive Regulation Of RNA Metabolic Process Positive Regulation Of Myelination Regulation Of Appetite Positive Regulation Of Nucleobase-containing Compound Metabolic Process Embryonic Eye Morphogenesis Regulation Of Primary Metabolic Process Cell Adhesion Mediated By Integrin BHLH Transcription Factor Binding Negative Regulation Of Osteoclast Differentiation Response To Hormone NF-kappaB Binding
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