TCF7 and NHERF2

Number of citations of the paper that reports this interaction (PubMedID 22466651)
52

Data Source:
BioGRID (pull down)

		TCF7	NHERF2
Description		transcription factor 7	NHERF family PDZ scaffold protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nuclear Body Beta-catenin-TCF Complex	Nucleus Plasma Membrane Focal Adhesion Endomembrane System Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity DNA Binding Protein Binding Beta-catenin Binding Sequence-specific Double-stranded DNA Binding	Signaling Receptor Binding Protein Binding Beta-catenin Binding Phosphatase Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Cadherin Binding Molecular Adaptor Activity
	Biological Process	Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Immune Response Wnt Signaling Pathway Gamma-delta T Cell Differentiation Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of DNA-templated Transcription Canonical Wnt Signaling Pathway Cellular Response To Interleukin-4	Protein-containing Complex Assembly Protein Localization To Plasma Membrane
Pathways		Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Ca2+ pathway Binding of TCF/LEF:CTNNB1 to target gene promoters Repression of WNT target genes Repression of WNT target genes RUNX3 regulates WNT signaling Germ layer formation at gastrulation Formation of axial mesoderm Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Medication use (thyroid preparations) ( 31015401) Menarche (age at onset) ( 25231870) Multiple sclerosis ( 21833088 24076602 31604244) Rheumatoid arthritis ( 32868391) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 26502338 27399966 28714469 33272962) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		5 interacting genes: GOLGA3 JADE2 NHERF2 SS18L1 UCHL5	47 interacting genes: ABCC4 ACE2 ACTN4 ACVR2B ADORA2B ADRB2 ATP2B2 BRSK2 CFTR DLGAP4 EZR IFT140 KCNJ1 LPAR1 LPAR2 P2RY1 PDGFRB PDPK1 PDZK1 PLCB3 PODXL PRKACA PRKCA PTEN PTH1R RDX RPS6KA1 SGK1 SGK3 SIAH1 SLC13A1 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC9A3 SLCO1A2 SLCO3A1 SRY TAFAZZIN TBC1D10A TCF7 TRAF4 UBC WWP2 WWTR1
Entrez ID		6932	9351
HPRD ID		01797	05946
Ensembl ID		ENSG00000081059	ENSG00000065054
Uniprot IDs		B3KQ75 P36402	H3BQS0 Q15599
PDB IDs			2D11 2HE4 2OCS 4P0C
Enriched GO Terms of Interacting Partners?			Apical Plasma Membrane PDZ Domain Binding Plasma Membrane Monoatomic Ion Transport Regulation Of Transport Brush Border Membrane Basolateral Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Sodium Ion Transport Regulation Of Biological Quality Membrane Regulation Of Monoatomic Ion Transport Transmembrane Transport Regulation Of Signal Transduction Positive Regulation Of Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway ATP Binding Regulation Of Intracellular Signal Transduction Chloride Channel Regulator Activity Carnitine Transmembrane Transport Carnitine Transport System Process Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Sodium-independent Organic Anion Transport Sodium-independent Organic Anion Transmembrane Transporter Activity Circulatory System Process Amino-acid Betaine Transport Metal Ion Transport Organic Cation Transport Organic Anion Transport Protein Phosphorylation Quaternary Ammonium Group Transport Xenobiotic Transport Carboxylic Acid Transport Organic Acid Transport Nucleotide Binding Protein Kinase Activity Vascular Process In Circulatory System Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Chemical Homeostasis Protein Serine/threonine Kinase Activity Intracellular Monoatomic Cation Homeostasis Positive Regulation Of Signal Transduction Intracellular Monoatomic Ion Homeostasis
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