TCF7 and JADE2

		TCF7	JADE2
Description		transcription factor 7	jade family PHD finger 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nuclear Body Beta-catenin-TCF Complex	Histone Acetyltransferase Complex Nucleoplasm Extracellular Exosome
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity DNA Binding Protein Binding Beta-catenin Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Zinc Ion Binding Transferase Activity Histone H3K14 Acetyltransferase Activity Histone H4K5 Acetyltransferase Activity Histone H4K8 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Metal Ion Binding Histone H4K16 Acetyltransferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Immune Response Wnt Signaling Pathway Gamma-delta T Cell Differentiation Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of DNA-templated Transcription Canonical Wnt Signaling Pathway Cellular Response To Interleukin-4	Regulation Of Cell Growth Regulation Of DNA Replication Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Regulation Of Cell Cycle Regulation Of DNA Biosynthetic Process
Pathways		Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Ca2+ pathway Binding of TCF/LEF:CTNNB1 to target gene promoters Repression of WNT target genes Repression of WNT target genes RUNX3 regulates WNT signaling Germ layer formation at gastrulation Formation of axial mesoderm Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Regulation of PD-L1(CD274) transcription	HATs acetylate histones
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Medication use (thyroid preparations) ( 31015401) Menarche (age at onset) ( 25231870) Multiple sclerosis ( 21833088 24076602 31604244) Rheumatoid arthritis ( 32868391) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 26502338 27399966 28714469 33272962) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Adult body size ( 32376654) Age at first birth ( 34211149 27798627) Body mass index ( 28892062) Brain morphology (MOSTest) ( 32665545) Coffee consumption ( 31046077) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hand grip strength ( 29691431) Household income (MTAG) ( 31844048) Mental health study participation (completed survey) ( 31263887) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Platelet distribution width ( 27863252) Smoking cessation ( 33082346) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 28869590) White blood cell count ( 32888494)
Interacting Genes		3 interacting genes: NHERF2 SS18L1 UCHL5	15 interacting genes: CBX8 CDCA7L CSNK2A1 FBXO7 GAS2L2 GORASP2 H3-4 ING4 PACSIN1 SASH1 TTC3 ZBTB3 ZBTB5 ZNF417 ZNF496
Entrez ID		6932	23338
HPRD ID		01797	15124
Ensembl ID		ENSG00000081059	ENSG00000043143
Uniprot IDs		B3KQ75 P36402	A0A087X085 A0A0C4DFT8 B3KPL2 B4DFY8 G3XAA4 Q9NQC1
PDB IDs
Enriched GO Terms of Interacting Partners?
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