TAP2 and PSMG3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TAP2	PSMG3
Description		transporter 2, ATP binding cassette subfamily B member	proteasome assembly chaperone 3
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Nuclear Speck Phagocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane MHC Class I Peptide Loading Complex TAP Complex	Cytosol Protein-containing Complex
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ABC-type Peptide Antigen Transporter Activity ABC-type Peptide Transporter Activity ATP Hydrolysis Activity MHC Class Ib Protein Binding MHC Protein Binding Peptide Antigen Binding Metal Ion Binding TAP1 Binding Tapasin Binding ABC-type Transporter Activity Peptide Transmembrane Transporter Activity	Protein Binding Protein-containing Complex Binding Molecular Adaptor Activity
	Biological Process	T Cell Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Response To Molecule Of Bacterial Origin Adaptive Immune Response Immune System Process Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-dependent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Via ER Pathway, TAP-dependent Peptide Antigen Assembly With MHC Class I Protein Complex Protein Transport Peptide Transport Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Cytosol To Endoplasmic Reticulum Transport Peptide Antigen Transport Transmembrane Transport	Proteasome Assembly Chaperone-mediated Protein Complex Assembly
Pathways		ER-Phagosome pathway ER-Phagosome pathway Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Proteasome assembly Proteasome assembly
Drugs
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency Bare lymphocyte syndrome (BLS) type1
GWAS		Asthma ( 31619474) Asthma and major depressive disorder ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Autism spectrum disorder or schizophrenia ( 28540026) Composite immunoglobulin trait (IgA/IgG) ( 28628107) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) IgA nephropathy ( 25305756) Lymphocyte count ( 32888494) Lymphoma ( 23349640) Nephropathy ( 21399633) Platelet distribution width ( 32888494) Pubertal anthropometrics ( 23449627) Response to hepatitis B vaccine ( 29534301) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Type 1 diabetes (age at diagnosis) ( 33179336) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Urate levels in lean individuals ( 25811787) Waist circumference adjusted for body mass index ( 34021172)	Executive inhibition (Stroop WIT and CIT) in attention deficit hyperactivity disorder ( 28416812) Femur bone mineral density x serum urate levels interaction ( 34046847) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		10 interacting genes: APP HLA-C HLA-G PSMB5 PSMB8 PSMG3 RBM18 TAP1 TAPBP TMUB1	6 interacting genes: PSMB1 PSMB3 PSMB4 PSMB5 PSMG4 TAP2
Entrez ID		6891	84262
HPRD ID		01360	14404
Ensembl ID		ENSG00000204267	ENSG00000157778
Uniprot IDs		Q03519 Q5JNW1 Q9UP03 X5CMH5	Q9BT73
PDB IDs		5U1D 8T46 8T4E 8T4F 8T4G 8T4H 8T4I 8T4J	2Z5E 6JPT 8QYJ 8TM3
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Antigen Processing And Presentation Of Endogenous Antigen Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Antigen Processing And Presentation Of Peptide Antigen Phagocytic Vesicle Membrane Lumenal Side Of Endoplasmic Reticulum Membrane TAP2 Binding TAP1 Binding MHC Class I Peptide Loading Complex MHC Class I Protein Complex Threonine-type Endopeptidase Activity Peptide Antigen Assembly With MHC Class I Protein Complex Proteasome Core Complex, Beta-subunit Complex Protein-containing Complex Assembly Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Proteasome Assembly Protein Trimerization Protein-containing Complex Organization MHC Class I Protein Binding Proteasome Core Complex Early Endosome Membrane Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Immune System Process Regulation Of T Cell Mediated Cytotoxicity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway ER To Golgi Transport Vesicle Membrane Regulation Of Natural Killer Cell Mediated Immunity Adaptive Immune Response Regulation Of Natural Killer Cell Mediated Cytotoxicity Peripheral B Cell Tolerance Induction Proteasome Complex MHC Class Ib Protein Complex Assembly Peptide Antigen Stabilization Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity External Side Of Plasma Membrane Cellular Component Assembly Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Acetylcholine Receptor Activator Activity Lipoprotein Particle	Proteasome Core Complex, Beta-subunit Complex Proteasome Core Complex Proteasome Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteasome Assembly Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Tapasin Binding Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Via ER Pathway, TAP-dependent ABC-type Peptide Antigen Transporter Activity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-dependent Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Peptide Transmembrane Transporter Activity TAP Complex Peptide Antigen Transport ABC-type Peptide Transporter Activity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class Ib TAP1 Binding Cytosol To Endoplasmic Reticulum Transport Catabolic Process MHC Class Ib Protein Binding Extracellular Exosome MHC Protein Binding MHC Class I Peptide Loading Complex Threonine-type Endopeptidase Activity Peptide Antigen Assembly With MHC Class I Protein Complex Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Protein-containing Complex Assembly T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Protein-containing Complex Organization Protein Metabolic Process Antigen Processing And Presentation Of Endogenous Antigen Negative Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I T Cell Mediated Immunity Peptide Antigen Binding Lipopolysaccharide Binding Cytosol Antigen Processing And Presentation Of Exogenous Peptide Antigen ABC-type Transporter Activity Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Exogenous Antigen
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